About the Book
The correct migration of neurons to specific targets underlies the normal formation and function of our nervous system. Defective movement of neurons results in their aberrant function or death, thus causing a range of developmental problems. Neurons move by responding to extracellular cues which alter the dynamic organization of cytoskeletal elements via complex and often overlapping signaling pathways. Changes in external cues or intracellular signaling molecules are responsible for altered neuronal movement and behavior, and are increasingly being associated with the occurrence of lissencephaly, epilepsy and mental retardation. This issue provides current findings and future directions towards understanding how the dynamic organization of the neuronal cytoskeleton affects movement and the consequences of normal and altered neuronal migration on the nervous system. The topics highlight the importance of specific proteins that regulate actin filaments and microtubules, and how their changes affect neuronal translocation. The effects of genetic or environmental alterations on the formation of the nervous system and the power of high-resolution imaging in analyzing both normal and defective development are emphasized. The volume will thus be of interest to a wide range of molecular and cellular neurobiologists, developmental biologists and neurologists.
Table of Contents:
Preface: Nikolic, M.; Reynolds, R.; Mini Reviews; Cerebellar Granule Cell Migration and the Effects of Alcohol: Jiang, Y.; Kumada, T.; Cameron, D.B.; Komuro, H.; Role of Intermediate Progenitor Cells in Cerebral Cortex Development: Pontious, A.; Kowalczyk, T.; Englund, C.; Hevner, R.F.; Migration of Neuroblasts from Neurogenic Placodes: Begbie, J,; Molecular Pathways Regulating Cytoskeletal Organization and Morphological Changes in Migrating Neurons: Kawauchi, T.; Hoshino, M.; Functions of Rac GTPases during Neuronal Development: de Curtis, I.; Function of PTEN during the Formation and Maintenance of Neuronal Circuits in the Brain: van Diepen, M.T.; Eickholt, B.J.; How Neuronal Migration Contributes to the Morphogenesis of the CNS: Insights from the Zebrafish: Mione, M.; Baldessari, D.; Deflorian, G.; Nappo, G.; Santoriello, C.; Histogenetic Processes Leading to the Laminated Neocortex: Migration Is Only a Part of the Story: Caviness, V.S.; Bhide, P.G.; Nowakowski, R.S.; The Potential Role of Cyclin-Dependent Kinase 5 in Focal Cortical Dysplasia: Sen, A.; Thom, M.; Nikolic, M.; Sisodiya, S.M.; Original Papers; Migratory Behavior of Presumptive Interneurons Is Affected by AMPA Receptor Activation in Slice Cultures of Embryonic Mouse Neocortex: Yozu, M.; Tabata, H.; Konig, N.; Nakajima, K.; Stromal-Derived Factor 1 Signalling Regulates Radial and Tangential Migration in the Developing Cerebral Cortex: Liapi, A.; Pritchett, J.; Jones, O.; Fujii, N.; Parnavelas, J.G.; Nadarajah, B.; Nocodazole-Induced Changes in Microtubule Dynamics Impair the Morphology and Directionality of Migrating Medial Ganglionic Eminence Cells: Baudoin, J.-P.; Alvarez, C.; Gaspar, P.; Metin, C.; The Role of DCX and LIS1 in Migration through the Lateral Cortical Stream of Developing Forebrain: Bai, J.; Ramos, R.L.; Paramasivam, M.; Siddiqi, F.; Ackman, J.B.; LoTurco, J.J.; Genetic Enhancement of the Lis1+/- Phenotype by a Heterozygous Mutation in the Adenomatous Polyposis Coli Gene: Hebbar, S.; Guillotte, A.M.; Mesngon, M.T.; Zhou, Q.; Wynshaw-Boris, A.; Smith, D.S.; Alternative Transcripts of Dclk1 and Dclk2 and Their Expression in Doublecortin Knockout Mice: Phan Dinh Tuy, F.; Saillour, Y.; Kappeler, C.; Chelly, J.; Francis, F.; Doublecortin Supports the Development of Dendritic Arbors in Primary Hippocampal Neurons: Cohen, D.; Segal, M.; Reiner, O.; Microtubule-Associated Protein 1B Interaction with Tubulin Tyrosine Ligase Contributes to the Control of Microtubule Tyrosination: Utreras, E.; Jimenez-Mateos, E.M.; Contreras-Vallejos, E.; Tortosa, E.; Perez, M.; Rojas, S.; Saragoni, L.; Maccioni, R.B.; Avila, J.; Gonzalez-Billault, C.; Exploring Cortical Subplate Evolution Using Magnetic Resonance Imaging of the Fetal Brain: Perkins, L.; Hughes, E.; Srinivasan, L.; Allsop, J.; Glover, A.; Kumar, S.; Fisk, N.; Rutherford, M.
