About the Book
This special issue of Neuroendocrinology focuses on neuroendocrine tumors of midgut and hindgut origin and the liver as a metastatic site of gut neuroendocrine tumors and is the necessary complement of Part 1 which was dedicated to foregut neuroendocrine tumors. Papers were generated at the Second ENETS Consensus Conference on Gastrointestinal Neuroendocrine Tumors, held in Frascati (Rome, Italy) in November 2006. Based on the current WHO classification of tumors, 56 experts and practicing clinicians confronted their experience with published evidence-based data. Reasonably effective strategies were consensually generated and standards set for the management of patients with this neglected cancer disease. The articles are organized on an anatomical basis. Specific issues are discussed and minimal consensus statements defined and highlighted for easy recognition. Topics include: Classification and Epidemiology; Clinical Presentation/Prognosis/Heredity; Diagnostic Procedures (imaging/laboratory tests); Pathology and Genetics; Surgical Therapy (curative and palliative); Locoregional Ablative Therapy; Liver Transplantation; Medical Therapy (biotherapy and chemotherapy); Peptide Receptor Radionuclide Therapy, and Follow-Up Scheduling. Readers will be able to find answers to debated questions for specific tumors, such as the diagnostic procedure for midgut classic carcinoids, follow-up for appendix carcinoids, or the algorithm for liver metastasis treatment of patients with extrahepatic spread from gut neuroendocrine carcinomas.
Table of Contents:
Introduction; Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors: The Second Event and Some Final Considerations: Rindi, G.; de Herder, W.W.; O'Toole, D.; Wiedenmann, B.; ENETS Guidelines; Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors - Well-Differentiated Jejunal-Ileal Tumor/Carcinoma: Eriksson, B.; Kloppel, G.; Krenning, E.; Ahlman, H.; Plockinger, U.; Wiedenmann, B.; Arnold, R.; Auernhammer, C.; Korner, M.; Rindi, G.; Wildi, S. and all other Frascati Consensus Conference participants; Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumours: Well-Differentiated Tumour/Carcinoma of the Appendix and Goblet Cell Carcinoma: Plockinger, U.; Couveland, A.; Falconi, M.; Sundin, A.; Salazar, R.; Christ, E.; de Herder, W.W.; Gross, D.; Knapp, W.H.; Knigge, U.P.; Kulke, M.H.; Pape, U.F. and all other Frascati Consensus Conference participants; Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumours: Well-Differentiated Colon and Rectum Tumour/Carcinoma: Ramage, J.K.; Goretzki, P.E.; Manfredi, R.; Komminoth, P.; Ferone, D.; Hyrdel, R.; Kaltsas, G.; Kelestimur, F.; Kvols, L.; Scoazec, J.-Y.; Sevilla Garciac, M.I.; Caplin, M.E. and all other Frascati Consensus Conference participants; Poorly-Differentiated Endocrine Carcinomas of Midgut and Hindgut Origin: Ahlman, H.; Nilsson, O.; McNicol, A.M.; Ruszniewski, P.; Niederle, B.; Ricke, J.; Jensen, R.; Kos-Kudla, B.; Oberg, K.; O'Connor, J.M.; Pavel, M.E.; Vullierme, M.P. and all other Frascati Consensus Conference participants; Consensus Guidelines for the Management of Patients with Liver Metastases from Digestive (Neuro)endocrine Tumors: Foregut, Midgut, Hindgut, and Unknown Primary: Steinmuller, T.; Kianmanesh, R.; Falconi, M.; Scarpa, A.; Taal, B.; Kwekkeboom, D.J.; Lopes, J.M.; Perren, A.; Nikou, G.; Yao, J.; Delle Fave, G.F.; O'Toole, D. and all other Frascati Consensus Conference participants.
