About the Book
Retrotransposable elements are major constituents of genomes. These mobile DNA sequences can disrupt genes, induce genomic rearrangements, influence gene expression and mobilize various types of non-autonomous sequences. Their genomic status is still controversial and an object of intense debate in the scientific community. On the one hand, retrotransposable elements are frequently considered as genome parasites or as ‘junk DNA’ causing genetic diseases and evolving as retroviruses. On the other hand, mobile DNA and transposition are driving forces of genome evolution. Many regulatory and coding sequences contain parts of transposable elements that are required for proper expression and function of resident genes and proteins. Some mobile sequences have been domesticated by the host and play important cellular roles. Valuable reading for researchers and teachers involved in genetics, genome structure and evolution, this publication updates the current knowledge on retrotransposition and retrotransposable elements and their impact on gene function and genome evolution.
Table of Contents:
Preface; Retrotransposable Elements, Retrotransposition and Genome Evolution; Echoes from the past - are we still in an RNP world?: Brosius J; What transposable elements tell us about genome organization and evolution: the case of Drosophila: Biemont C, Vieira C; LINEs, SINEs and processed pseudogenes: parasitic strategies for genome modeling: Dewannieux M, Heidmann T; Hybrid genome evolution by transposition: Fontdevila A; Retrotransposable Elements, Chromosomes and Chromatin; Clustering, duplication and chromosomal distribution of mouse SINE retrotransposons: Jurka J, Kohany O, Pavlicek A, Kapitonov VV, Jurka MV; Heterochromatic distribution of HeT-A- and TART-like sequences in several Drosophila species: Berloco M, Fanti L, Sheen F, Levis RW, Pimpinelli S; Retroelements: tools for sex chromosome evolution: Steinemann S, Steinemann M; Retrotransposable elements on the W chromosome of the silkworm Bombyx mori: Abe H, Mita K, Yasukochi Y, Oshiki T, Shimada T; Retrotransposition and Its Regulation; Transcriptional interference mediated by retrotransposons within the genome of their host: lessons from alleles of the White gene from Drosophila melanogaster. Desset S, Vaury C; I elements in Drosophila: in vivo retrotransposition and regulation: Chambeyron S, Bucheton A; The structures of mouse and human L1 elements reflect their insertion mechanism: Martin SL, Li W-LP, Furano AV, Boissinot S; Stress activation and genomic impact of Tnt1 retrotransposons in Solanaceae: Grandbastien M-A, Audeon C, Bonnivard E, Casacuberta JM, Chalhoub B, Costa A-PP, Le QH, Melayah D, Petit M, Poncet C, Tam SM, Van Sluys M-A, Mhiri C; Retrotransposable Elements and Gene Evolution; A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes: Brandt J, Veith AM, Volff J-N; Human endogenous retroviruses: from infectious elements to human genes: de Parseval N, Heidmann T; Transposable elements donate lineage-specific regulatory sequences to host genomes: Marino-Ramirez L, Lewis KC, Landsman D, Jordan IK; Impact of transposable elements on the evolution of mammalian gene regulation: Medstrand P, van de Lagemaat LN, Dunn CA, Landry JR, Svenback D, Mager DL; Evolution of Retrotransposable Elements; Mobile genetic elements and sexual reproduction: Arkhipova IR; Evolutionary forces generating sequence homogeneity and heterogeneity within retrotransposon families: Brookfield JFY; Ribonuclease H evolution in retrotransposable elements: Malik HS; The recent evolution of human L1 retrotransposons: Boissinot S, Furano AV; Extinction of LINE-1 activity coincident with a major mammalian radiation in rodents: Grahn RA, Rinehart TA, Cantrell MA, Wichman HA; Diversity of Retrotransposable Elements; Classification and nomenclature of retrotransposable elements: Capy P; Repbase Update, a database of eukaryotic repetitive elements: Jurka J, Kapitonov VV, Pavlicek A, Klonowski P, Kohany O, Walichiewicz J; Genome-wide experimental identification and functional analysis of human specific retroelements: Buzdin A, Vinogradova T, Lebedev Y, Sverdlov E; SINEs and LINEs: symbionts of eukaryotic genomes with a common tail: Ohshima K, Okada N; Retrons, msDNA, and the bacterial genome: Lampson BC, Inouye M, Inouye S; Transposable elements in mosquitoes: Boulesteix M, Biemont C; Author Index.
