About the Book
The development of head and neck cancer is a multistep process in which genetic as well as epigenetic alterations interfere with the regular functions of proto-oncogenes and tumor suppressor genes. In addition, carcinogenesis is promoted by the impairment of mechanisms responsible for the maintenance of genetic stability. The accumulation of crucial events such as evasion of apoptosis, lack of senescence, deregulated proliferation, invasion and metastasis, as well as neoangiogenesis eventually determines the malignant phenotype. The 16 articles of this volume span from advances in the understanding of underlying molecular pathways (conditional mouse model, folate activity, DNA repair, genomic heterogeneity, p53 family members, human papillomavirus), to preclinical and clinical studies investigating potential novel therapeutic targets (epidermal growth factor receptor, nuclear factor-kappaB, vascular endothelial growth factor, chemokine receptors, P53-based immunotherapy, virus-modified tumor vaccination), and biometric considerations on the evaluation of prognostic factors. This state-of-the-art publication is recommended reading not only for ENT specialists and oncologists, but also for molecular biologists and other subspecialists interested in head and neck cancer research.
Table of Contents:
Development of a Conditional Mouse Model for Head and Neck Squamous Cell Carcinoma: Bindels, E.M.J.; van de Brekel, M.W.M. Hypofolatemia as a Risk Factor for Head and Neck Cancer: Almadori, G.; Bussu, F.; Galli, J.; Cadoni, G.; Paludetti, G.; Maurizi, M. Reduced DNA Repair Capacity in Laryngeal Cancer Subjects. A Comparison of Phenotypic and Genotypic Results: Gajacka, M.; Rydzanicz, M.; Jaskura-Sztul, R.; Wierzbicka, M.; Szyfter, W.; Szyfter, K. Intratumoral Genomic Heterogeneity in Advanced Head and Neck Cancer Detected by Comparative Genomic Hybridization: Gotte, K.; Tremmel, S.C.; Popp, S.; Weber, S.; Hormann, K.; Bartram, C.R.; Jauch, A. Function and Importance of p63 in Normal Oral Mucosa and Squamous Cell Carcinoma of the Head and Neck (SCCHN): Thurfjeil, N.; Coates, P.J.; Boldrup, L.; Lindgren, B.; Baoklund, B.; Uusitalo, T.; Mahani, D.; Dabelsteen, E.; Dahiqvist, A.; Sjostrom, B.; Roos, G.; Vojtesek, B.; Nenutil, R.; Nylander, K. P53, P63, and P73 - Expression in Squamous Cell Carcinomas of the Head and Neck and Their Response to Cisplatin Exposure: Balz, V.; Scheckenbach, K.; Gwosdz, C.; Bier, H. Expression of p16 Protein is Associated with Human Papillomavirus Status in Tonsillar Carcinomas and has Implications on Survival: Wittekindt, C.; Gultekin, E.; Weissenborn, S.J.; Dienes, H.P.; Pfister, H.J.; Klussmann, J.P. EGFR Antibody -Supplemented TPF-Chemotherapy. Preclinical Investigations to a Novel Approach for Head and Neck Cancer Induction Treatment: Knecht, R.; Peters, S.; Hambek, M.; Solbach, C.; Baghi, M.; Gatottner, W.; Hambek, M. Anti-Angiogenic Therapy of Head and Neck Squamous Cell Carcinoma by VEGF Antisense Therapy: Riedel, F.; Gotte, K.; Hormann, K.; Rubin Grandis, J. NF-[kappa]B as a Common Target and Activator of Oncogenes in Head and Neck Squamous Cell Carcinoma: Chang, A.A.; Van Waes, C. Expression Pattern of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck Identifies a Novel Metastatic Phenotype: Wang, J.; XI, L.; Gooding, W.; Godfrey, T.E.; Ferris, R.L. p53-Based Immunotherapy of Cancer: De Leo, A.B. p53 as an Immunotherapeutical Target in Head Neck Cancer: Approaches to Reversing Unresponsiveness of T-Lymphocytes and Preventing Tumor Escape: Hoffmann, T.K.; Bier, H.; Donnenberg, A.D.; Whiteside, T.L.; De Leo, A.B. Imbalance in Absolute Counts of T Lymphocyte Subsets in Patients with HNC and its Relation to Disease: Kuss, I.; Hathaway, B.; Ferris, R.L.; Gooding, W.; Whiteside, T.L. Anti-Tumor Immunization of HNSCC Patients with a Virus-Modified Autologous Tumor Cell Vaccine: Herold-Mende, C.; Karcher, J.; Dyckhoff, G.; Schirrmacher, V. Prognostic Factors - Confusion Caused by Bad Quality of Design, Analysis and Reporting of Many Studies: Sauerbrei, W.
