About the Book
The future of neurosurgery will be characterized by less invasive, molecular technologies that promise to revolutionize the field of neurosurgery and impact the treatment of additional neurological disorders, including neurometabolic diseases, stroke, dementias, affective and psychiatric diseases, movement disorders, epilepsy, and others. This book encompasses developing an understanding of the principles underlying the advent of novel molecular approaches to neurological and neurosurgical diseases. It Identifies key principles that will allow dramatic improvement in the treatment and outcomes of patients suffering from a varity of disorders affecting the central nervous system and spinal axis. This volume gives neurosurgeons an excellent understanding of the development of novel molecular and cellular technologies that will markedly change the way neurosurgery is practiced in the near future. It is also of special interest to neurologists, psychiatrists, physiatrists, spinal orthopeadic surgeons, neurobiologists and gene therapy research scientists.
Table of Contents:
Dedication Acknowledgements Series Editor's Note: Lunsford, L.D. Foreword: Anderson, W.F. Introduction: Freese, A.; Janson, C.; Leone, P.; Simeone, F.A. The Spine and Spinal Cord The Molecular Basis of Intervertebral Disc Degeneration: Leo, B.M.; Walker, M.H.; Anderson, D.G. Genetics of Degenerative Disc Disease: Kurpad, S.N.; Lifshutz, J. Gene Therapy for Degenerative Disc Disease: Kim, J.; Gilbertson, L.G.; Kang, J.D. Bone Morphogenetic Proteins. Spinal Fusion Applications: Bomback, D.A.; Grauer, J.N. Cellular and Gene Therapy Approaches to Spinal Cord Injury: Steinmetz, M.P.; Liu, J.K.; Boulls, N.M. Neural Stem Cell Transplantation for Spinal Cord Repair: Iwanami, A.; Ogawa, Y.; Nakamura, M.; Kaneko, S.; Sawamoto, K.; Okano, H.J.; Toyama, Y.; Okano, H. Functional and Restorative Molecular Neurosurgery Contemporary Applications of Functional and Stereotactic Techniques for Molecular Neurosurgery: House, P.A.; Rao, G.; Couldwell, W. Xeno-Neurotransplantation: Schumacher, J.M. Adeno-Associated Viral Vectors for Clinical Gene Therapy in the Brain: Samulski, R.J.; Giles, J. Molecular Mechanisms of Epilepsy and Gene Therapy: Telfeian, A.; Celix, J.; Dichter, M. Emerging Treatment of Neurometabolic Disorders: Brady, R.O.; Brady, R.O., Jr. Gene Therapy for Parkinson's Disease: Hadaczek, P.; Daadi, M.; Banklewicz, K. Simplifying Complex Neurodegenerative Diseases by Gene Chip Analysis: Scherzer, C.R.; Gullans, S.R.; Jensen, R.V. Molecular Pathology of Dementia. Emerging Treatment Strategies: Gouras, G.K. Expanding the Role of Deep Brain Stimulation from Movement Disorders to Other Neurological Diseases: Leone, M.; Franzini, A.; Broggi, G.; Bussone, G. Molecular Mediators of Pain: Chaudhary, P.; Burchiel, K. Gene Transfer in the Treatment of Pain: Fink, D.; Mata, M.; Glorioso, J.C. Neurovascular Disorders Gene Discovery Underlying Stroke: Barone, F.C.; Read, S.J. Molecular Mediators of Hemorrhagic Stroke: Macdonald, R.L. Advances towards Cerebrovascular Gene Therapy: Watanabe, Y.; Heistad, D.D. Ex vivo Gene Therapy and Cell Therapy for Stroke: Kondziolka, D.; Sheehan, J.; Niranjan, A. Neuro-Oncology Neurosurgical Applications for Polymeric Drug Delivery Systems: Wang, P.P.; Brem, H. Immunotherapy Strategies for Treatment of Malignant Gliomas: Harshyne, L.; Flomenberg, P.; Andrews, D.W. Glioma-Genesis. Signaling Pathways for the Development of Molecular Oncotherapy: Kapoor, G.S.; O'Rourke, D.M. Oncolytic Viral Therapy for Glioma: Lamfers, M.L.M.; Visted, T.; Chiocca, E.A. Molecular Neurosurgery in the Pituitary Gland. Gene Transfer as an Adjunctive Treatment Strategy: Castro, M.G.; Jovel, N.; Goverdhana, S.; Hu, J.; Yu, J.; Ehtesham, M.; Yuan, X.; Greengold, D.; Xiong, W.; Lowenstein, P.R. Stem Cells for Targeting CNS Malignancy: Yip, S.; Sidman, R.L.; Snyder, E.Y. Autor Index Subject Index
