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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Endocrinology > Hypothalamic-Pituitary Development: Genetic and Clinical Aspects(4 Endocrine Development)
Hypothalamic-Pituitary Development: Genetic and Clinical Aspects(4 Endocrine Development)

Hypothalamic-Pituitary Development: Genetic and Clinical Aspects(4 Endocrine Development)


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About the Book

In recent years, dramatic progress has been made in understanding the pathophysiology of pituitary diseases by a combination of experimental studies, molecular genetics and clinical research. This volume presents an updated overview of normal and pathological hypothalamic-pituitary development. Several chapters include experimental data and describe brain and facial defects associated with various conditions of pituitary insufficiency. A major part is devoted to the still increasing number of molecular and genetic defects which are responsible for various clinical presentations of pituitary insufficiency: diseases due to genetic defects of growth hormone, TSH, gonadotropins and corticotropin secretion are extensively described. These diseases present as metabolic (diabetes insipidus and adrenal insufficiency), growth and reproductive (including puberty) disorders. A distinct chapter emphasizes the contribution of a multidisciplinary comprehensive approach including the most recent molecular and genetic tools.

Table of Contents:
Genetic regulation of forebrain and pituitary development; neural crest and pituitary development; perspectives on the molecular basis of developmental defects in the human pituitary region; growth hormone-releasing hormone receptors and pituitary development; pituitary transcription factors, POU1F1 and PROP1 defects; septo-optic dysplasia and related malformations; magnetic resonance imaging of the hypothalamic-pituitary region in nontumoral hypopituitarism; Kallmann syndrome - towards molecular pathogenesis; genetic basis of hypothalamic-pituitary hypogonadism; molecular pathology of corticotroph function; central diabetes insipidus.


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Product Details
  • ISBN-13: 9783805572392
  • Publisher: S Karger Ag
  • Publisher Imprint: S Karger AG
  • Language: English
  • Series Title: 4 Endocrine Development
  • Weight: 530 gr
  • ISBN-10: 3805572395
  • Publisher Date: 06 Jul 2001
  • Binding: Hardback
  • No of Pages: 180
  • Sub Title: Genetic and Clinical Aspects


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Hypothalamic-Pituitary Development: Genetic and Clinical Aspects(4 Endocrine Development)
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Hypothalamic-Pituitary Development: Genetic and Clinical Aspects(4 Endocrine Development)
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