Energy Metabolism in Brain Function and Neuroprotection: 3rd International Conference, Waterville Valley, N.H., July 1997. Special Topic Issue: Developmental Neuroscience 1998, Vol. 20, No. 4-5

Authored by internationally acclaimed scientists, this publication presents the most recent data on finely tuned, highly coordinated metabolic exchanges between neurons and astrocytes which are key to brain function. It contains exciting new evidence regarding the regulation of transporters, key enzymes and adaptive mechanisms of brain tissue in response to alterations in the supply and demand of energy nutrients. This up-to-date publication underscores the renewed interest in understanding processes in the CNS, which are involved in the regulation of key cellular and metabolic mechanisms which underlie function as well as pathology. In addition, this volume includes a major section that elucidates how dysfunction of energy metabolism expresses itself in various neurodegenerative mechanisms. By emphasizing innovative research directions in this clinically relevant field, this volume will be of interest to a broad spectrum of neuroscientists as well as researchers in physiology, biochemistry and nutrition who are interested in development and energy metabolism.

Table of Contents:
Astrocyte-neuron metabolic pathways: introduction, P.J. Magistretti; evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle, L. Pellerin et al; lactate transport by cortical synaptosomes from adult rat brain - characterization of kinetics and inhibitor specificity, M.C. McKenna et al; comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C NMR spectroscopy, H.S. Waagepetersen et al; functional energy metabolism - in vivo 13C MR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivity, N.R. Sibson et al; glucose and lactate metabolism in C6 glioma cells - evidence for the preferential utilization of lactate for cell oxidativemetabolism, A.-K. Bouzier et al; can experimental conditions explain the discrepancy over glutamate stimulation of aerobic glycolysis, L. Hertz et al; brain anaerobic lactate production - a suicide note or a survival kit?, A. Schurr and B.M. Rigor; ketone bodies and brain glutamate and GABA metabolism, Y. Daikhin and M. Yudkoff; studies of the source of glucose in the extracellular compartment of the rat brain, M. Fillenz and J.P. Lowry; glucose transporter expression in brain - relationship to cerebral glucose utilization, S.J. Vannucci et al; localized in vivo 13C NMR of glutamate metabolism in the human brain - initial results at 4 tesla, R. Gruetter et al; in vitro and in vivo 13C MR spectroscopy studies of pyruvate recycling in brain, A. Haberg et al. Interrelationships of energy metabolism to oxidative damage and neurodegeneration: introduction, W.J. Nicklas; glutathione restoration as indicator for cellular metabolism of astroglial cells, R. Dringen and B. Hamprecht; metabolic control of kynurenic acid formation in the rat brain, P.S. Hodgkins and R. Schwarcz; multinuclear MR spectroscopy studies on NH4CI-induced metabolic alterations and detoxification processes in primary astrocytes and glioma cells, C. Zwingmann; in vivo investigation of glutamate-glutamine metabolism in hyperammonaemic monkey brain using 13C Magnetic resonance imaging, Y. Tsukada et al; 15N MR spectroscopy studies of ammonia transport and glutamine synthesis in the hyperammonaemic rat brain, J. Shen et al; excitoxicity and oxidative stress during inhibition of energy metabolism, G.D. Zeevalk et al; disturbances of the blood-brain barrier without expression of amyloid precursor protein-containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs, N.Y. Calingasan et al; glyceraldehyde 3-phosphate dehydrogenase abnormality in metabolically stressed Huntingdon disease fibroblasts;, A.J.L. Cooper et al; brain ATP metabolism in hypoxia resistant mice fed gunaidinopropionic acid, D. Holtzman et al; evidence for a central cholinergic deficit in congenital ornithine trancarbamylase deficiency, R.F. Butterworth. (Part Contents).