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Home > Medicine & Health Science textbooks > Surgery > Surgical orthopaedics and fractures > Tissue Engineering: Neues zum Gewebeersatz im Muskel-Skelett-System
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Tissue Engineering: Neues zum Gewebeersatz im Muskel-Skelett-System

Tissue Engineering: Neues zum Gewebeersatz im Muskel-Skelett-System


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About the Book

Aktueller Überblick zum Tissue engineering von Knorpel, Knochen, Sehnen, Bändern und Muskeln. - Vom Experiment zur klinischen Anwendung. - Aspekte der Zell- und Gewebegewinnung und der Zelldifferenzierung. - Gentechnologie, Wachstumsfaktoren, Matrices. - Möglichkeiten der physiko-mechanischen Stimulation.

Table of Contents:
1 Einführung.- 1.1 Tissue engineering und regenerative Medizinin der rekonstruktiven Chirurgie.- 1.2 Physiko-mechanische Stimulation von Zellen am Beispiel des Gelenkknorpels.- 2 Tissue engineering von Knorpelgewebe in vitro.- 2.1 Kollagensynthese humaner adulter Chondrozytenin Alginatkultur.- 2.2 CEP-68: Ein neuer Marker für kultivierte Chondrozyten.- 2.3 Gentechnische Veränderung und Kultivierungvon Kaninchenchondrozyten.- 2.4 Die Vermeidung der „Scarring-Reaktion“ bei der Herstellung von Gelenkflächenimplantaten.- 3 Tissue engineering von Korpelgewebe in vivio.- 3.1 Probleme bei der histologischen Beurteilung von Reparationsgewebe.- 3.2 Erste Ergebnisse der lokalen Applikationeines Kollagen-I/GDF-5-Komposits im „Full thickness“-Defekt am Kaninchen.- 3.3 Die Rolle von Matrices im Tissue engineering.- 3.4 Vergleich kokultivierter synthetischerund biologischer Trägermaterialien bei der Behandlung osteochondraler Defekte.- 3.5 Soft-Tissue-engineering unter Verwendung von Fibrinkleber.- 4 Soft-Tissue-engineering(Sehnen, Muskelgewebe, Menisken).- 4.1 Funktionelle Anpassungsvorgänge an Zug- und Gleitsehnen.- 4.2 Tissue engineering mesenchymaler Gewebe.- 4.3 Die Rolle von Wachstumsfaktoren beim Soft-Tissue-engineering.- 4.4 Gentherapie und Tissue engineering mittels Skelettmuskelstammzellen.- 4.5 Soft-Tissue-engineering von Menisken.- 4.6 Die Aktivierung des Transkriptionsfaktors NF-KB und des Protoonkogens c-fos in humanen Fibroblasten nach zyklischer mechanischer Dehnung.- 5 Modulation von Heilungsvorgängen.- 5.1 Growth and differentiation factor-5(GDF-5)- beschichtetes Nahtmaterial stimuliertdie Sehnenheilung im Achillessehnenmodellin der Ratte.- 5.2 Die Modulation der Kollagensynthese von humanen Fibroblasten durch zyklische Dehnung.- 5.3Hitzeschockprotein 72 (HSP 72) verstärkt die Stresstoleranz humaner Fibroblasten nach zyklischer mechanischer Dehnung.- 6 Tissue engineering mit embryonalen Stammzellen.- 6.1 Differenzierung embryonaler Stammzellen — neue Perspektiven für Zell-und Gewebeersatz.- 6.2 Knorpelzelldifferenzierung in vitro aus embryonalen Stammzellen der Maus.- 7 Therapie von Knorpelschäden beim Menschen.- 7.1 Die autologe Chondrozytentransplantation (ACT)- Historie, Technik, Ergebnisse.- 7.2 Erfahrungen nach 150 Knorpel-Knochen-Transplantationen (KKT) am Kniegelenk.


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Product Details
  • ISBN-13: 9783798514010
  • Publisher: Steinkopff Darmstadt
  • Publisher Imprint: Steinkopff Darmstadt
  • Height: 235 mm
  • No of Pages: 255
  • Sub Title: Neues zum Gewebeersatz im Muskel-Skelett-System
  • ISBN-10: 3798514011
  • Publisher Date: 18 Sep 2003
  • Binding: Hardback
  • Language: German
  • Returnable: Y
  • Width: 155 mm


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