Alpha-Keto Acid Dehydrogenase Complexes
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Alpha-Keto Acid Dehydrogenase Complexes: (Molecular and Cell Biology Updates)

Alpha-Keto Acid Dehydrogenase Complexes: (Molecular and Cell Biology Updates)

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About the Book

Found in all organisms, the alpha-keto acid dehydrogenase complexes have central roles in cellular metabolism and are major sites of regulation. The understanding of the organization, function and regulation of these quintessential multienzyme complexes has been greatly advanced by studies employing molecular biology and biophysical techniques. Although these enzyme systems have some features in common, their diversity in fulfilling unique organism - or tissue - specific roles is truly amazing. These systems have medical importance in areas ranging from defects in regulation (linked to diabetes, heart disease, obesity, nutrition defects), to inherited diseases (inborn errors, maple syrup urine disease) to acquired immune diseases (primary biliary cirrhosis). This book brings together wide-ranging recent findings on the structure(function relationships, gene regulation, and genetic defects of the alpha-keto acid dehydrogenase complexes, namely the pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and the branched-chain alpha-keto acid dehydrogenase complexes. A wide variety of experimental approaches together with new results presented in this book should serve as a resource for beginning to established investigators in the field as well as scientists who are interested in mitochondria, dehydrogenases, kinases, phosphatases, lipoic acid, thiamine pyrophosphate, and enzyme complexes.

Table of Contents:
Interaction of protein domains in the assembly and mechanism of 2-oxo acid dehydrogenase multienzyme complexes.- Probing the active site of mammalian pyruvate dehydrogenase.- Role of the E2 core in the dominant mechanisms of regulatory control of mammalian pyruvate dehydrogenase complex.- Lipoamide dehydrogenase.- Plant pyruvate dehydrogenase complexes.- Regulation of the pyruvate dehydrogenase complex during the aerobic/anaerobic transition in the development of the parasitic nematode, Ascaris suum.- Structure, function and assembly of mammalian branched-chain ?-ketoacid dehydrogenase complex.- Lipoylation of E2 component.- Pyruvate dehydrogenase phosphatase.- The mitochondrial ?-ketoacid dehydrogenase kinases: Molecular cloning, tissue-specific expression and primary structure analysis.- Shorter term and longer term regulation of pyruvate dehydrogenase kinases.- Hormonal and nutritional modulation of PDHC activity status.- Regulation of branched-chain ?-keto acid dehydrogenase complex in rat liver and skeletal muscle by exercise and nutrition.- Dephosphorylation of PDH by phosphoprotein phosphatases and its allosteric regulation by inositol glycans.- Long-term regulation and promoter analysis of mammalian pyruvate dehydrogenase complex.- The sperm-specific pyruvate dehydrogenase E1? genes.- Molecular defects of the branched-chain ?-keto acid dehydrogenase complex: maple syrup urine disease due to mutations of the E1? or E1? subunit gene.- Human defects of the pyruvate dehydrogenase complex.- Multigenic basis for maple syrup urine disease with emphasis on mutations in branched chain dihydrolipoyl acyltransferase.- Structure and chromosomal localization of the human 2-oxoglutarate dehydrogenase gene.- Pyruvate dehydrogenase complex as an autoantigen in primary biliary cirrhosis.


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Product Details
  • ISBN-13: 9783764351816
  • Publisher: Birkhauser Verlag AG
  • Publisher Imprint: Birkhauser Verlag AG
  • Language: English
  • Returnable: Y
  • Weight: 890 gr
  • ISBN-10: 3764351810
  • Publisher Date: 29 Feb 1996
  • Binding: Hardback
  • No of Pages: 321
  • Series Title: Molecular and Cell Biology Updates


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Alpha-Keto Acid Dehydrogenase Complexes: (Molecular and Cell Biology Updates)
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