Analysis of Free Radicals in Biological Systems
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Analysis of Free Radicals in Biological Systems

Analysis of Free Radicals in Biological Systems


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About the Book

The main aim of this text is to provide a comprehensive survey on recent methodological aspects of the measurement of damage within cellular targets, information which may be used as an indicator of oxidative stress. In the introductory chapters, emphasis is placed on the chemical properties of reactive oxygen species and their role in the induction of cellular modifications together with their links to various diseases. The central part of the book is devoted to the description of selected methods aimed at monitoring the production of free radicals in cellular systems. In addition, several assays are provided to assess the chemical damage induced by reactive oxygen species in critical cellular-targets in vitro and in humans in vivo. Thus both practical aspects and general considerations, including discussion on the applications and limitations of the assays, are critically reviewed. One of the major features of the book is the description of new experimental methods. These include the measurement of oxidized DNA bases and nucleosides, new techniques for determination of LDL oxidation using spin-trap agents, and the use of salicylate as an indicator of oxidative stress. In addition, more classical though significantly improved techniques devoted to the measurement of hydroperoxides and aldehydes are described. This book should serve a large scientific community including biologists, chemists and clinicians working on the chemical and biological effects of oxidative stress. It may also be of interest to investigators in the fields of drug, cosmetic and new food research.

Table of Contents:
Mechanisms of oxidative stress.- Chemistry of dioxygen and its activated species.- Biological sources of reduced oxygen species.- Nitric oxide: Chemistry and biology.- Pro-oxidant and antioxidant effects of nitric oxide.- Oxidative damage to DNA.- Oxidation of low density lipoprotein (LDL) by cells.- Oxidative stress in clinical situation.- Free radicals and antioxidants in human diseases.- How to demonstrate the occurrence of an oxidative stress in human?.- New developments in ESP and spin-trapping.- EPR evidence of generation of superoxide anion radicals (O2·-) by irradiation of a PDT photosensitizer: Hypericin.- Nitrone spin traps as reagents for the study of oxidative modification of low density lipoproteins: Implications for atherosclerosis.- Ascorbate radical: A valuable marker of oxidative stress.- Determination of lipid peroxidation-derivated products.- Lipid hydroperoxide analysis by reverse-phase high-performance liquid chromatography with mercury cathode electrochemical detection.- Determination of primary and secondary lipid peroxidation products: Plasma lipid hydroperoxides and thiobarbituric acid reactive substances.- Measurement of low-density lipoprotein oxidation.- Evaluation of DNA damages.- Determination of 8-oxo-purines in DNA by HPLC using amperometric detection.- Measurement of one of the features of apoptosis: DNA fragmentation.- Measurement of plasma sulfhydryl and carbonyl groups as a possible indicator of protein oxidation.- Measurement of oxidized nucleobases and nucleosides in human urine by using a GC/MS assay in the selective ion monitoring mode.- Miscellaneous techniques.- Methodological and practical aspects for in vitro studies of oxidative stress on cell culture models (toxicity and protection).- Detection and production of nitric oxide.- Salicylate hydroxylation products assay as a marker of oxidative stress in man: A sensitive HPLC-electrochemical method.


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Product Details
  • ISBN-13: 9783764351373
  • Publisher: Birkhauser Verlag AG
  • Publisher Imprint: Birkhauser Verlag AG
  • Language: English
  • Returnable: Y
  • ISBN-10: 3764351373
  • Publisher Date: 29 Nov 1995
  • Binding: Hardback
  • No of Pages: 312
  • Weight: 850 gr


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Analysis of Free Radicals in Biological Systems
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