About the Book
This book illustrates in a unique way the most common diseases affecting the human nervous system using different imaging modalities derived from radiology, nuclear medicine, and neuropathology. The features of the diseases are visualized on computerized tomography (CT)-scans, magnetic resonance imaging (MRI)-scans, nuclear medicine scans, surgical intraoperative as well as gross-anatomy and histology preparations. For each disease entity, the structural changes are illustrated in a correlative comparative way based on the various imaging techniques. The brain diseases are presented in a systematic way allowing the reader to easily find the topics in which she or he is particularly interested. In Part 1 of the book, the imaging techniques are described in a practical, straightforward way. The morphological built-up of the normal human brain and its vascular supply are presented in Part 2. The chapters of the subsequent Parts 3 to 10 deal with the following diseases involving the nervous system including: hemodynamic, vascular, infectious, neurodegenerative, demyelination, epilepsy, trauma and intoxication, and tumors.
The authors incite the clinician to see the cell, the tissue, the organ, the disorder by enabling him to recognize brain lesions or interpreting histologic findings and to correlate this knowledge with molecular biologic concepts. Thus, this book bridges the gap between neuro-clinicians, neuro-imagers and neuro-pathologists. The information provided will facilitate the understanding of the disease processes in the daily routine work of neurologists, neuroradiologists, neurosurgeons, neuropathologists, and all allied clinical disciplines.
Table of Contents:
Part I. The techniques.- 1. Imaging modalities - Radiology.- 1.1. CT.- 1.2. MR Imaging.- 1.3. MR Spectroscopy.- 1.4. Perfusion imaging.- 1.5. Diffusion-weighted imaging (DWI).- 1.6. Diffusion Tensor Imaging (DTI).- 1.7. Functional MRI (fMRI).- 2. Imaging modalities - Nuclear Medicine.- 2.1. SPECT.- 2.2. PET - [11 C]-Methionine (MET).- 2.3. PET - [18 F]-Fluordeoxyglucose (FDG).- 2.4. PET - [18 F]-Fluorethyltyrosine (FET).- 2.5. PET - [18 F]-Fluorothymidine (FLT).- 2.6. PET - [18 F]-Fluorodihydroxyphenylalanine (DOPA).- 3. Imaging Modalities - Neuropathology.- 3.1. Gross-anatomy.- 3.2. Histology.- 3.3. Immunohistochemistry.- Part II. The normal human brain.- 4. The normal human brain.- 4.1. Subdivisions of the nervous system.- 4.2. Gross-anatomy of the nervous system.- 4.3. Ventricular system – Cerebrospinal fluid – Barriers.- 4.4. Meninges.- 4.5. Histological constituents of the nervous system.- 4.6. Microscopical built-up of the nervous system.- 4.7. Functional systems.- 5. Vascular supply of the brain.- 5.1. Arterial supply.- 5.2. Venous drainage.- Part III. The brain diseases – Edema and Hydrocephalus.- 6. Brain edema.- 7. Hydrocephalus.- Part IV.- The Brain diseases – Vascular system.- 8. Vascular disorders – Hypoxia.- 9. Vascular disorders – Ischemic lesions.- 10. Vascular disorders – Hemorrhage.- 11. Vascular disorders – Angiopathies.- Part V. The brain diseases – Infections.- 12. Infections – Bacteria.- 13. Infections – Viruses.- 14. Infections – Parasites.- 15. Infections – Fungi.- 16. Prion diseases.- Part VI. The brain diseases – Aging and neurodegeneration.- 17. Normal aging brain.- 18. Neurodegenerative disorders - Alzheimer's disease.- 19. Neurodegenerative disorders – Lewy body disease.- 20. Neurodegenerative disorders – Fronto-temporal lobe dementia.- 21. Neurodegenerative disorders – Multi-infarct dementia.- 22. Neurodegenerative disorders – Binswanger disease.- 23. Neurodegenerative disorders – Progressive supranuclear palsy.- 24. Neurodegenerative disorders - Parkinson's disease.- 25. Neurodegenerative disorders – Amyotrophic lateral sclerosis.- 26. Neurodegenerative disorders – Huntington disease.- Part VII. The brain diseases – Myelin disorders.- 27. Demyelinating diseases – Multiple Sclerosis.- 28. Neuromyelitis optica.- 29. ADEM.- Part VIII. The brain diseases – Epilepsy.- 30. Temporal lobe epilepsy.- 31. Cortical dysplasia.- Part IX. The brain diseases – Tumors.- 35. Tumors of the nervous system – General considerations.- 36. Tumors – Astrocytoma WHO II – Anaplastic Astrocytoma WHO III.- 37. Tumors – Glioblastoma WHO IV.- 38. Tumors – Gliosarcoma WHO IV – Giant cell Glioblastoma WHO IV.- 39. Tumors – Pilocytic astrocytoma WHO I.- 40. Tumors – Oligodendroglioma WHO II – Anaplastic oligodendroglioma WHO III.- 41. Tumors – Oligo-astrocytoma WHO II – Anaplastic Oligo-Astrocytoma WHO III.- 42. Ependymal tumors.- 43. Choroid plexus tumors – Papilloma – Carcinoma.- 44. Neuronal and mixed neuronal-glial tumors.- 45. Pineal parenchymal tumors.- 46. Embryonal tumors.- 47. Tumors of cranial and spinal nerves – Schwannoma.- 48. Tumors of cranial and spinal nerves – Neurofibroma.- 49. Tumors of cranial and spinal nerves – Perineuroma.- 50. Tumors of cranial and spinal nerves – Malignant peripheral nerve sheath tumor (MPNST).- 51. Tumors of meningothelial cells.- 52. Mesenchymal, non-meningothelial tumors.- 53. Lymphomas and haematopoetic neoplasms.- 54. Germ cell tumors.- 55. Cysts and tumor-like lesions.- 56. Tumors of the sellar region.- 57. Metastatic tumors.- 58. Paraneoplastic syndromes – Autoimmune diseases.- 59. Radiation injury.
About the Author :
Prof. Dr. Serge Weis is the head of the Division of Neuropathology at the Neuromed Campus of the Kepler University Hospital, Johannes Kepler University, Linz, Austria. He is a native of Luxembourg, studied medicine at the University of Vienna (Austria). He was trained in neuropathology at the Ludwig-Maximilians University, Munich, Germany. He was deputy director at the Department of Neuropathology, Otto-von Guericke University Magdeburg (Germany) and director of Neuropathology at the Stanley Medical Research Institute, Bethesda, MD, USA. His scientific interests are focused on brain tumors, neurodegeneration and biological psychiatry. He edited the largest book in German-speaking countries on Alzheimer disease and wrote a book, published in 1993, on 3D reconstruction of the brain.
Dr. Michael Sonnberger is a senior consultant in neuroradiology at the Department of Neuroradiology of the Neuromed Campus of the Kepler University Hospital, Johannes Kepler University, Linz, Austria. He studied medicine at the University of Innsbruck (Austria) and was trained in radiology/neuroradiology at the University of Regensburg (Germany) and at the State Neuropsychiatric Hospital Wagner-Jauregg, Linz, Austria. His fields of expertise are interventional neuroradiology and stroke.
Dr. Andreas Dunzinger is a senior consultant in nuclear medicine at the Department of Nuclear Medicine of the Neuromed Campus of the Kepler University Hospital, Johannes Kepler University, Linz, Austria. He studied medicine at the University of Vienna (Austria). He was trained as a general physician at the Hospital of the Sisters of Mercy, Linz, Austria, and in nuclear medicine at the Medical University of Graz and at the State Neuropsychiatric Hospital Wagner-Jauregg, Linz, Austria. His field of expertise is neuro nuclear medicine and neuroendocrinology.
Dr. Eva Voglmayr is a trainee in radiology and neuroradiology at the Department of Neuroradiology of the Neuromed Campus of theKepler University Hospital, Johannes Kepler University, Linz, Austria. She studied medicine at the University Vienna. Her field of interest is neurodegeneration.
Dr. Martin Aichholzer is deputy head of the Department of Neurosurgery at the Neuromed Campus of the Kepler University Hospital, Johannes Kepler University, Linz, Austria. He studied medicine at the University of Vienna and was trained at the Department of Neurosurgery of the Medical University Vienna (Austria). His field of expertise is skull base surgery.
Dr. Raimund Kleiser is a medical physicist and is the head of the imaging center at the Institute of Neuroradiology at the Kepler University Hospital in Linz. He studied physics in Freiburg im Breisgau (Germany) and supplemented his training with the specialization in medical physics. His focus is on functional imaging, for which he established fMRT measuring equipment in prestigious institutions in Germany, Switzerland and Austria.
Dr. Peter Strasseris molecular biologist at the PMU University Institute for Medical & Chemical Laboratory Diagnostics of the Paracelsus Medical University in Salzburg, Austria. He studied general biology at the University of Salzburg and specialized in biochemistry and molecular genetics. Dr. Strasser’s current focus of interest lies in the genetic background of neurological diseases.
Review :
“This hugely comprehensive tome … attempts and largely achieves the ambitious aim of covering not only the radiological findings of brain diseases, but also their macro and micro histopathological findings, intraoperative appearances at neurosurgery and the molecular basis of some of these conditions. … this is a thorough overview of CNS conditions affecting the brain. … it would make a useful reference text for a department’s library, and for those wishing to rediscover any lost affection for histopathology slides.” (Mark Igra, RAD Magazine, April, 2022)
