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Home > Medicine & Health Science textbooks > Medicine: general issues > Gitoformat — ein nicht-nierenpflichtiges Digitalisglykosid
Gitoformat — ein nicht-nierenpflichtiges Digitalisglykosid

Gitoformat — ein nicht-nierenpflichtiges Digitalisglykosid


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About the Book

Nicht-nierenpflichtige Digitalisglykoside ge- Tabelle 1: Gitalin-Fraktion aus Digitalis purpurea winnen neben dem immer noch am häufigsten Gitoxin 13.3 % verordneten nierenpflichtigen Digoxin zu- 11.0 % Digitoxin nehmendes Interesse in der Therapie der chro- 16-Formylgitoxin 10,6 % nischen Herzinsuffizienz. Zwei Faktoren sind (Gitaloxin) dafür maßgebend, nämlich eine von der Nieren- Strospesid 4.0 % andere Glykoside 8.0 % funktion unabhängige Elimination verbunden herzunwirksame Bestandteile 50-55 % mit einem geringeren therapeutischen Risiko bei älteren Patienten und ein weitgehender Ver- zicht auf kostenintensive Konzentrationsbe- Tabelle 2: Stabilität von 16-Formylgitoxin stimmungen. ( Gitaloxin) Zu den nicht-nierenpflichtigen zählen u.a. die - hoch stabil in Gegenwart von Begleitstoffen Derivate des Gitoxins, nämlich Pentaacetyl- und - labil in H ü, Alkohol, alkalischen und sauren 2 Pentaformylgitoxin. Pentaformylgitoxin und Lösungen sein herzwirksamer Metabolit 16-Formylgitoxin oder Gitaloxin konnten pharmakologisch und klinisch schon vor etwa 30 Jahren charakteri- Tabelle 3: Enterale Wirksamkeit beim Meer- siert und definiert werden. schweinchen (resorbiert in % der Die Gitalinfraktion aus Digitalis purpurea ent- Dosis letalis bei 2h Infusion) hält neben einem hohen Anteil an nicht-herz- 4.0 % Gitoxin wirksamen Ballaststoffen mit ähnlichen Lös- 5.8 % Strospesid lichkeitseigenschaften (Haack et al., 1956) Digi- 19.5 % Digitoxin toxin und Gitaloxin als resorbierbare und herz- 24.9 % 16-Formylgitoxin (Gitaloxin) wirksame Glykoside (Tabelle 1). 16-Formyl- gitoxin ist in Gegenwart der Ballaststoffe hoch stabil, jedoch sehr labil in H20, Alkohol und sauren und alkalischen Lösungen (Tabelle 2).

Table of Contents:
Einführung.- I. Grundlagen der Therapie beim alten Menschen.- Zur Problematik der Pharmakotherapie im Alter.- Morphologisch-biochemische Veränderungen von Herz und Gefäßen im Alter.- II. Pharmakokinetik und Pharmakodynamik von Gitoformat.- Von der Pflanze bis zum Pentaformylgitoxin.- Radioimmunologische Bestimmung von Gitoformat und Metaboliten nach vorausgehender Trennung mit HPLC.- Pharmakodynamik von Gitoformat.- Pharmakokinetik und Wirkungskinetik von Gitoformat.- III. Anwendung von Gitoformat in Klinik und Praxis.- Intrakardiale Druckmessung unter Gitoformat.- Neue Aspekte zur Wahl des Herzglykosids: Nierenpflichtige und nicht nierenpflichtige Herzglykoside.- Klinische Erfahrungen mit dem Herzglykosid Gitoformat.- Gitoformat zur Behandlung der Herzinsuffizienz.- Gitoxin-Monitoring bei älteren Patienten unter Gitoformat-Therapie.- Behandlung der latenten und manifesten Herzinsuffizienz mit Gitoformat.- Eine Multicenterstudie: Gitoformat in der Praxis.- Personen- und Sachwortverzeichnis.


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Product Details
  • ISBN-13: 9783663019336
  • Publisher: Springer Fachmedien Wiesbaden
  • Publisher Imprint: Vieweg+Teubner Verlag
  • Height: 254 mm
  • No of Pages: 134
  • Returnable: N
  • ISBN-10: 3663019330
  • Publisher Date: 16 Dec 2012
  • Binding: Paperback
  • Language: German
  • Returnable: Y
  • Width: 178 mm


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Gitoformat — ein nicht-nierenpflichtiges Digitalisglykosid
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