The Dose-Response Relationship of Vitamin E and Lung Cancer Risk

Document from the year 2013 in the subject Medicine - Neoplasms, Oncology, language: English, abstract: Lung cancer is considered one of the most common and fatal form of cancer and as such, it requires urgent attention from medical researchers in order to slow its current epidemic proportions. This book analyzes the dose-response relationship of vitamin E intake on the risk of developing lung cancer, with emphasis placed on both dietary and supplemental intakes of vitamin E, as well as the various barriers to identifying the biological processes that drive lung cancer formation. The aim of the book is to improve our understanding of the empirical and mechanism-based vitamin E-lung cancer models, and to aid in developing new strategies for the treatment and prevention of lung cancer. The book sets the stage for a discussion on the dose-response modeling of vitamin E intake and lung cancer risk by briefly describing the concept of dose-response and its quantified strength of association in two selected cohort studies, and by presenting the cellular mechanisms through which vitamin E may exert its anti-cancer activity. Safe and beneficial dietary and supplemental doses of vitamin E are estimated, as are its critical doses. Throughout the book, gaps in knowledge relating to the evaluation of the relationship between vitamin E intake and lung cancer risk, especially those in dose-response analyses, are revealed. Understanding these gaps and their implications can inform the design of new dose-response studies, which may add to our knowledge of vitamin E activity and shed light on issues related to its bioavailability and action in lung cells. The book concludes by summarizing the main conclusions and implications derived from this assessment.

About the Author :
Dr. Widad Akrawi is a geneticist and global health expert, and one of Scandinavia's most successful female human rights and peace activists. Born in Kurdistan region, she graduated as a civil engineer in 1990, and proceeded on to the Technical University of Denmark where she earned a Masters degree in genetics and microbiology. After graduation, she served as a clinical geneticist and researcher in human genetics and inherited diseases at the Danish Royal Hospital, the largest hospital in Denmark and a leading university hospital in Northern Europe. She has also earned a PhD degree in global health and (cancer) epidemiology, with her dissertation focusing on analysing the 1999-2010 NHANES datasets on lung cancer development and vitamin E intake and the potential modification effects of dietary fat and fatty acids intake. Dr. Akrawi became a published author in 2003 and has since published several medical textbooks and academic articles. After researching the concept of victim psychology and the effects of various types of trauma on individuals' psychological health, her first novel entitled "Tara's Book," written in Danish, was published in Copenhagen. The book was translated to Norwegian in 2005, published in Oslo, and recognised by the Norwegian Cultural Council. Her eBook, entitled "Under Habets Skygge" (Under the Shadow of Hope), also in Danish, was published in 2013 at Amazon.com and Lulu.com. Her medical books and scholarly research papers can be found on Amazon and elsewhere. All revenues generated from the sales of her publications are completely donated to charity. Dr. Akrawi currently leads Defend International, a Norway-based NGO that is devoted to medical research and human rights. Over the years, she has addressed and attended numerous regional and international meetings and conferences, such as the United Nations Third and Fourth Biennial Meeting of States, the UN Commission on The Status of Women, the General Assembly Interactive Hearings with Non-Governmental organisations, Civil society organisations and the Private sector, and the UN First Committee on Disarmament and International Security. She has held many leadership positions in national and international organisations, including Executive Board member of Amnesty International Denmark, ambassador for Amnesty International's "Stop Torture" campaign, and member of the Panel of Vestby Experts on approaches to socio-cultural constructivism. At present, she is an Executive Board member of Women of Europe Award, an active member of International Action Network on Small Arms (IANSA), a board member of IANSA Women's Network Working Group, and a senior lobbyist at the UN, encouraging member states to sign and ratify the international Arms Trade Treaty during the meetings that take place at the UN General Assembly's First Committee on Disarmament and International Security.