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Home > Mathematics and Science Textbooks > Biology, life sciences > Biochemistry > Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation(Springer Theses)
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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation(Springer Theses)

Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation(Springer Theses)


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About the Book

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.

Table of Contents:
Introduction.- Recent advances in the chemistry and biology of stable synthetic Lipoxin analogues.- Synthesis of Heck coupling partner for the preparation of heteroaromatic Lipoxin A4 analogues.- Synthesis and biological evaluation of pyridine-containing Lipoxin A4 analogues.- Thiophene-containing Lipoxin A4 analogues: synthesis and their effect on the production of key cytokines.- Towards the synthesis of various heteroaromatic Lipoxin A4 analogues.


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Product Details
  • ISBN-13: 9783642246319
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Publisher Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Height: 235 mm
  • No of Pages: 130
  • Returnable: Y
  • Sub Title: Synthesis and Biological Evaluation
  • ISBN-10: 3642246311
  • Publisher Date: 05 Jan 2012
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Series Title: Springer Theses
  • Width: 155 mm


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