Efeito in-vitro do citocromo P450 no cancro da mama
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Efeito in-vitro do citocromo P450 no cancro da mama

Efeito in-vitro do citocromo P450 no cancro da mama


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About the Book

A terapia hormonal é a primeira terapia orientada, também designada por terapia de supressão de estrogénios, frequentemente utilizada como terapia adjuvante para reduzir o risco de recidiva do cancro após a cirurgia ou de cancro que se espalhou. Os inibidores da aromatase, como o anastrozol, são um tipo comum de terapia hormonal; interferem com a capacidade do organismo para produzir estrogénio a partir do androgénio, suprimindo a enzima aromatase em mulheres pós-menopáusicas com cancro da mama com recetor de estrogénio positivo. A aromatase (citocromo P450), também designada por síntese de estrogénios, é uma enzima responsável por uma etapa fundamental na biossíntese dos estrogénios. Os inibidores da aromatase têm um papel central na terapia endócrina para o cancro da mama positivo para o recetor de estrogénio (RE) em mulheres pós-menopáusicas, pois interferem com a capacidade do organismo para produzir estrogénio a partir de androgénios, suprimindo a atividade da enzima aromatase. Os inibidores da aromatase utilizam dois mecanismos distintos para bloquear a ação da aromatase e, assim, reduzir a produção de estrogénios.


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Product Details
  • ISBN-13: 9783639885736
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Height: 229 mm
  • No of Pages: 60
  • Spine Width: 4 mm
  • Width: 152 mm
  • ISBN-10: 3639885732
  • Publisher Date: 15 Apr 2025
  • Binding: Paperback
  • Language: Portuguese
  • Returnable: N
  • Weight: 145 gr


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