The CD4 Molecule
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The CD4 Molecule: (Vol 205 Current Topics in Microbiology and Immunology)

The CD4 Molecule: (Vol 205 Current Topics in Microbiology and Immunology)


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About the Book

During the late 1970's the application of hybridoma technology led to an explosion in the discovery and characterization of proteins expressed at the surface of hematopoietic cells. The understanding of T lymphocyte biology benefited enormously from this advance and from newly developed techniques for obtaining clonal T cells. Application of these methodologies resulted in the identification of the clonally restricted T cell antigen receptors (TCRs) and of a number of other molecules expressed more broadly on T cells. Among these, the CD4 and CD8 glycoproteins stood out because they were differentially expressed on distinct functional subsets of T lymphocytes. Moreover, blocking studies with monoclonal antibodies sug- gested a functional role for CD4 and CD8 in T cell responses to antigen. Shortly thereafter, it was shown that T helper cells were the primary targets for the human immunodeficiency virus (HIV) and that CD4 serves as the viral receptor on these cells. These findings fueled an intense interest in CD4 during the last decade, in the hope that understanding the molecular nature of the HIV-CD4 interaction could hold the key to controlling AIDS.

Table of Contents:
List of Contents.- The Structure of CD4.- The Structural Basis of CD4-MHC Class II Interactions: Coreceptor Contributions to T Cell Receptor Antigen Recognition and Oligomerization-Dependent Signal Transduction.- CD4 and Signal Transduction.- Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck.- The Regulation and Function of the CD4 Coreceptor During T Lymphocyte Development.- Endocytic and Exocytic Regulation of CD4 Expression and Function.- The Receptor for HIV: Dissection of CD4 and Studies on Putative Accessory Factors.- The Role of CD4 in HIV Envelope-Mediated Pathogenesis.

Review :
"...will undoubtedly provide an outstanding reference for students and researchers for some years to come." - Immunology Today


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Product Details
  • ISBN-13: 9783540593447
  • Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
  • Publisher Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
  • Height: 235 mm
  • Returnable: N
  • Weight: 430 gr
  • ISBN-10: 3540593446
  • Publisher Date: /12/1996
  • Binding: Hardback
  • Language: English
  • Series Title: Vol 205 Current Topics in Microbiology and Immunology
  • Width: 155 mm


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