About the Book
This volume is one of a set of concise, well-illustrated and authoritative studies of natural and experimental lesions of laboratory animals (rat, mouse and hamster) arranged by organ systems. Carefully identified pathologic features are correlated with biologic, toxicologic and behavioral data. The frequency and significance of specific lesions in different species and strains from different geographic regions and laboratory environments are depicted graphically. The significance of each lesion is considered and comparisons are made with other species including man. The authors are specialists working in laboratories throughout the world, and each contribution is critically reviewed by an international editorial board. As with other volumes in the set, an internationally applicable nomenclature for recording and evaluating pathologic data produced in safety studies is proposed.
Table of Contents:
Bone Marrow and Peripheral Blood.- Structure and function.- Regulation of Hemopoiesis.- Evaluation of Blood and Bone Marrow, Rat.- Normal Blood Cell Values, Rat.- Neoplasms.- Granulocytic Leukemia, Rat.- Granulocytic Leukemia, Mouse.- Megakaryocytic Leukemia, Mouse.- Histiocytic Sarcoma, Rat.- Histiocytic Sarcoma, Mouse.- Nonneoplastic Lesions.- Myelofibrosis, Mouse.- Chediak-Higashi Syndrome, Mouse.- Assessment of Toxicologic Effects upon Bone Marrow and Related Tissues.- Parasites.- Hemobartonellosis and Eperythrozoonosis.- Trypanosoma Brucei Infection, Mouse.- Lymph Nodes.- Structure and function.- Identification and Functional Characteristics of Lymphocytes with Natural Killer Activity.- Identification and Functional Characteristics of T Lymphocytes.- B-Cell Function and Ontogeny.- Identification and Functional Characteristics of Monocytes/Macrophages.- Immunohistochemistry, Lymphoid Cells, Mouse.- Sources of Antibodies and Immunological Reagents Used for Immunohistochemistry.- Normal Anatomy, Histology, Immunohistology, and Ultrastructure, Lymph Node, Rat.- Neoplasms.- Classification of Mouse Lymphoid Cell Neoplasms.- Immunoblastic Lymphoma, Ileocecal Lymph Nodes, LOU/C Rat.- Follicular Center Cell Lymphoma, Mouse.- A Morphologic Classification of Hemopoietic Tumors, Rats.- Nonneoplastic Lesions.- Classification of Reactive Lesions of Lymph Nodes.- Autoimmune Hemolytic Anemia, NZB Mice.- Toxic Effects on the Immune System, Rat.- Spleen.- Structure and Function.- Normal Anatomy, Histology, Ultrastructure, Rat.- Neoplasms.- Large Granular Lymphocyte Leukemia, Rat.- Immunohistochemistry of Large Granular Lymphocyte Leukemia, Rat.- Mast Cell Neoplasms, Mouse.- Erythroleukemia, Mouse.- Early Follicular Center Cell Lymphoma, Mouse.- Fibrosarcoma, Spleen, Rat.- Nonneoplastic Lesions.- Classification of Reactive Lesions, Spleen.- Pigment Deposition, Rat, Mouse.- Extramedullar Hemopoiesis, Spleen, Rat.- Amyloidosis, Spleen, Mouse.- Fibrosis, Spleen, Rat.- Thymus.- Structure and Function.- Normal Anatomy, Histology, Immunohistology, Ultrastructure, Rat.- Development and Aging, Thymus, Rat.- Neoplasms.- Lymphoblastic Lymphomas, Mouse.- Thymoma, Lymphocytic, Rat.- Thymoma, Epithelial, Rat.- T-Cell Lymphoma, Thymic Origin, Rat.- Nonneoplastic Lesions.- Atrophy of Thymus Induced by Cytostatic Chemicals, Rat.- Other Hemopoietic Tissues.- Bronchus-Associated Lymphoid Tissue, Rat, Normal Structure.- Gut-Associated Lymphoid Tissue, Rodent, Normal Structure and Function.- Intraepithelial Leukocytes, Murine.
