Ce in Biotechnology: Practical Applications for Protein and Peptide Analyses
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Ce in Biotechnology: Practical Applications for Protein and Peptide Analyses: (5 Chromatographia CE-series)

Ce in Biotechnology: Practical Applications for Protein and Peptide Analyses: (5 Chromatographia CE-series)


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About the Book

The goal of this book is to show recent developments in the CE analysis of protein pharmaceuticals. It is devoted completely to practical concerns to strengthen the use of CE within the biotechnology industry, highlighting the uses of CE in various areas of product development including formulation studies, process development, product characterization and validated lot release and stability testing.

Table of Contents:
Capillary Electrophoresis in the Development of Recombinant Protein Biopharmaceuticals - Selection of Buffers in Capillary Zone Electrophoresis: Application to Peptide and Protein Analysis - Reverse-Phase High Performance Liquid Chromatography and Capillary Zone Electrophoresis Separation of Protegrin Analogs - Use of Capillary Electrophoresis to Determine the Dilute Protein Concentration in Formulations containing Interfering Excipients - The Effect of Solution Environment on the Resolution of Recombinant Human Deoxyribonuclease Variants in Capillary Zone Electrophoresis - Recent Advances in Capillary Isoelectric Focusing - Separation of Enbrel(R) (rhuTNFR:Fc) Isoforms by Capillary Isoelectric Focusing - Optimization, Validation, and Use of Capillary Gel Electrophoresis for Quality Control Testing of SynagisO, a Monoclonal Antibody - Analysis of Protein Therapeutics by Capillary Electrophoresis - Sensitive and High Resolution CE/MS/MS for Protein Identification in Complex Mixtures

About the Author :
Anthony B. Chen, Ph.D. has worked for over fifteen years at Genentech Inc. South San Francisco, CA developing analytical assays for recombinant protein pharmaceuticals. He introduced the use of novel analytical applications, including CE, for routine protein analyses in the Quality Control department. Wassim Nashabeh, Ph.D. has worked with CE for over ten years, including pre- and postdoctoral studies and CE for commercial applications. He is Associate Director, Quality Control, Genentech Inc. where he has validated several CE methods used in the lot release of marketed protein therapeutics. Timothy Wehr, Ph.D. developed CE instrumentation and application kits as manager of the CE chemistry R&D group at Bio-Rad laboratories, Richmond, CA and has developed CE methods for biopharmaceuticals at Bay Bioanalytical Laboratory, Richmond CA.


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Product Details
  • ISBN-13: 9783528031428
  • Publisher: Springer Fachmedien Wiesbaden
  • Publisher Imprint: Vieweg+Teubner Verlag
  • Height: 297 mm
  • Returnable: N
  • Weight: 433 gr
  • ISBN-10: 3528031425
  • Publisher Date: 29 Mar 2001
  • Binding: Hardback
  • Language: German
  • Series Title: 5 Chromatographia CE-series
  • Width: 210 mm


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Ce in Biotechnology: Practical Applications for Protein and Peptide Analyses: (5 Chromatographia CE-series)
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Ce in Biotechnology: Practical Applications for Protein and Peptide Analyses: (5 Chromatographia CE-series)
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