Macrocyclic Polyamines Synthesis and Applications

The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. ?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials ?Provides a comprehensive reference for the researchers working on macrocyclic polyamines ?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.

Table of Contents:
1. Introduction 1.1. Classification of macrocyclic polyamines 1.2. Properties of macrocyclic polyamines 1.3. Application of macrocyclic polyamines 2. Synthetic Methods of Macrocyclic Polyamines 2.1. Introduction 2.2. Aliphatic (or saturated) macrocyclic polyamines 2.3. Macrocyclic polyamines containing aromatic rings 2.4. Macrocyclic amides 2.5. Macrocyclic imines 2.6. Cross-linked macrocyclic polyamines 3. Chemical Nucleases Based on Macrocyclic Polyamines 3.1. Introduction 3.2. Hydrolysis of nucleic acid 3.2.1. Metal complexes of macrocyclic ligands 3.2.2. Metal-free macrocyclic polyamines 3.3. Oxidative cleavage of nucleic acid 3.4. Summary 4. The Derivatives of Macrocyclic Polyamines as Nano-vector Materials 4.1. Introduction 4.2. Derivatives of macrocyclic polyamines as non-viral gene vectors 4.2.1. Cationic polymers 4.2.2. Lipids with cationic macrocyclic polyamine headgroups 4.2.3. Other types of vectors 4.3. Multifunctional materials for both drug delivery and bio-imaging 4.3.1. Gd complexes 4.3.2. Cu64 complexes 4.4. Miscellaneous 4.5. Summary 5. Macrocyclic Polyamines Derivatives for Bio-imaging 5.1. Introduction 5.2. Typical macrocyclic polyamines for magnetic resonance imaging (MRI) 5.2.1. DOTA and its derivatives 5.2.2. DO3A and its derivatives 5.2.3. PCTA and its derivatives 5.2.4. TETA and NOTA 5.3. Other derivatives of macrocyclic polyamine for MRI 5.3.1. Phosphonate macrocyclic ligands 5.3.2. Amide macrocyclic ligands 5.3.3. Ligands with hydroxy arms 5.3.4. Other types 5.4. Macrocyclic polyamines for PET imaging 6. Chemical Sensors/Receptors Based on Macrocyclic Polyamines 6.1. Introduction 6.2. Sensors for metal cations 6.2.1. Zn(II) and Cd(II) 6.2.2. Cu(II) and Pb(II) 6.2.3. Hg(II) , Ag(I) and others 6.3. Receptors for anions 6.3.1. Phosphonates 6.3.2. Amino acids 6.3.3. Other anions 6.4. pH indicator 6.5. Sensors for bioactive molecules 6.5.1. Small molecules 6.5.2. Proteins 6.5.3. Others 7. Other Applications of Macrocyclic Polyamines 7.1. Macrocyclic polyamines for exaction and separation of metal ions 7.2. Macrocyclic polyamines for organic catalysis 7.3. Bioactivities of macrocyclic polyamines 7.4. Self-assembly of macrocyclic polymaines 7.5. Others

About the Author :
Xiao-Qi Yu is Changjiang Chair professor and Dean of College of Chemistry, Sichuan University. He has received several awards, including Distinguished Young Scholars Awarded (2007, National Science Foundation of China), New Century Excellent Talent Award (2003, Ministry of Education of China). His research interests include biomedical materials chemistry (especially for non-viral gene and drug delivery vectors) and methodology of organic syntheses (green synthetic methodologies). He has published over 300 scientific papers on international journals including JACS, Angew. Chem. Int. Ed., Coord. Chem. Rev., Biomaterials, Chem. Commun., Green Chem., etc. Ji Zhang is now a professor in College of Chemistry, Sichuan University, China. His current research focuses on nano-biomaterials, i.e. design, synthesis and establishment of novel non-viral gene and drug delivery systems and relative structure-activity relationship (SAR) studies. He is also interested in green organic synthetic methodology with high efficiency and selectivity, including microwave-assisted organic synthesis. He has authored over 100 scientific publications and received several awards both in scientific and teaching areas.