Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.
Table of Contents:
List of Contributors XVII
Preface XXV
Part I Analytical Methods and Strategies in Metallomics 1
1 The Position of Metallomics Within Other Omics Fields 3
Dirk Schaumlöffel
1.1 Introduction 3
1.2 Metallome and Metallomics in Relation to Other “-Ome” and “-Omics” Fields 3
1.3 Is Metallomics Feasible as a Global Study of the Metallome 7
1.4 Approaching the Metallome: Study of Metallome Subgroups 8
1.5 Analytical Strategies in Metallomics 8
1.6 Functional Connections Between DNA, Proteins, Metabolites, and Metals 10
1.7 Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup 11
1.8 Concluding Remarks 14
References 15
2 Coupling Techniques and Orthogonal Combination of Mass Spectrometric Techniques 17
Daniel Pröfrock
2.1 Introduction 17
2.2 Analytical Techniques for Metallomics 19
2.3 Ionization Principles and Mass Spectrometric Detectors for Speciation 30
2.4 Overview about Coupling Techniques 48
2.5 Final Remarks and Outlook 58
References 58
3 Quality Control in Speciation Analysis Using HPLC with ICP-MS and ESI MS/MS: Focus on Quantitation Strategies Using Isotope Dilution Analysis 69
Heidi G. Infante
3.1 Introduction 69
3.2 Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation 70
3.3 The Role of Species-Specific Isotope Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species 72
References 81
4 Novel Methods for Bioimaging Including LA-ICP-MS, NanoSIMS, TEM/X-EDS, and SXRF 83
Dirk Schaumlöffel, Robert Hutchinson, Julien Malherbe, Philippe Le Coustumer, Etienne Gontier, and Marie-Pierre Isaure
4.1 Introduction 83
4.2 Bioimaging by LA-ICP-MS 84
4.3 Bioimaging by NanoSIMS 90
4.4 Bioimaging by TEM/X-EDS 93
4.5 Bioimaging by SXRF 104
4.6 Conclusions and Outlook 108
References 109
5 Electrochemistry Coupled toMass Spectrometry for Investigating Oxidative Metabolism of Pt-Based Drug Conjugates: A Novel Approach 117
Günther Weber
5.1 Introduction 117
5.2 EC-MS Methodology 119
5.3 EC-MS of Thiols 119
5.4 Influence of Cisplatin on Thiol Oxidation 121
5.5 Conclusions 125
References 126
Part II Metallomics in Environment and Nutrition 129
6 Selenium and Selenium Species 131
6.1 Speciation Analysis Especially of Tin and Selenium in Environmental Matrices 131
Maria Ochsenkühn-Petropoulou and Fotios Tsopelas
References 143
6.2 Selenium Species Extraction and Speciation in Plants and Yeast 151
Lena Ruzik, Katarzyna Bier?a, and Joanna Szpunar
References 169
7 Arsenic and As Species 173
7.1 Arsenic Species in Marine Food 173
María Carmen Barciela-Alonso and Pilar Bermejo-Barrera
References 198
7.2 Compounds with As–S Bonds: Analytical and Biogeochemical Reasons Why These Species have been Elusive in Biota and Environment 202
Jörg Feldmann, Andrea Raab, Helle R. Hansen, Katharina Bluemlein, and Dirk Wallschläger
References 218
7.3 Arsenolipids: An overview of current analytical aspects 222
Michael Stiboller, Ronald A. Glabonjat, Georg Raber, Kenneth B. Jensen, and Kevin A. Francesconi
References 234
8 Analytical Procedures for Speciation of Chromium, Aluminum, and Tin in Environmental and Biological Samples 237
Radmila Milâcîc, Tea Zuliani, Janja Vidmar, and Janez Šcancar
8.1 Speciation of Chromium 237
8.2 Speciation of Aluminum 250
8.3 Speciation of Tin 260
References 275
9 Mercury Toxicity and Speciation Analysis 285
Eva M. Krupp, Zuzana Gajdosechova, Tanja Schwerdtle, and Hanna Lohren
9.1 Mercury Toxicity 285
9.2 Mercury Speciation Analysis 291
References 298
10 Environmental Speciation of Platinum Emissions from Chemotherapy 305
Marianna Vitkova, Gunda Koellensperger, and Stephan Hann
10.1 Introduction 305
10.2 Elemental Analysis of Platinum 306
10.3 Quantification Strategies 309
10.4 Preparation of Samples for Total Platinum Analysis by ICP-MS 309
10.5 Analysis of Platinum 310
10.6 Speciation of Platinum Emissions from Chemotherapy 311
10.7 Speciation Strategies for the Determination of CPC 312
10.8 Selected Applications 312
10.9 Conclusion 314
References 315
11 Nanoparticles in Environment and Health Effect 319
Gaëtane Lespes
11.1 Introduction 319
11.2 Nanoparticle Overview 319
11.3 Analytical Strategies 326
11.4 Conclusion 334
References 335
Part III Metallomics in Medicine and Biology 339
12 Metalloproteins 341
Maria Montes-Bayón and Elisa Blanco-González
12.1 General Introduction to Metalloprotein Analysis 341
12.2 Sample Preparation Methodologies to Preserve Metal–Protein Interactions 342
12.3 Analytical Strategies for Identification of Metalloproteins 344
12.4 Quantitative Strategies for the Analysis of Metalloproteins 349
References 355
13 Biomedical and Pharmaceutical Applications 359
13.1 Selenium and Selenoproteins in Human Health and Diseases 359
Jordan Sonet, Anne-Laure Bulteau, and Laurent Chavatte
Acknowledgments 370
References 370
13.2 Metal Species as Biomarkers for Medical Diagnosis: A Case Study of Alzheimer’s Disease 375
Tamara García-Barrera, José Luis Gómez-Ariza, and Belén Callejón-Leblic
References 385
13.3 Vanadium Speciation as a Means in Drug Development and Monitoring for Diabetes 388
Volker Nischwitz
References 398
13.4 Analysis of Pt- and Ru-Based Anticancer Drugs: New Developments 401
Sarah Theiner, Luis Galvez, Gunda Koellensperger, and Bernhard K. Keppler
References 416
13.5 Silver Distribution in Skin duringWound Healing 420
Marco Roman and Carlo Barbante
References 436
13.6 Neurodegeneration with Focus on Manganese and Iron Speciation 442
Katharina Neth, Julia Bornhorst, and Bernhard Michalke
References 457
Index 463
About the Author :
Bernhard Michalke is leader of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Center Munich - German Research Center for Environmental Health.
Since 1996 he has been lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, where he received his habilitation in analytical chemistry in 1999. Since 1988, he is principal researcher at the Helmholtz Center Munich.
His reasearch interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neuro-degenerative elements such as manganese and species related neuro-toxic effects in the central nervous system. He has published more than 170 peer reviewed articles and 10 book chapters. Since 1998, he has been co-organizer of several international conferences.
Review :
"This book covers a comprehensive and broad range of relevant topics in the field of Metallomics with an intended focus on analytical techniques and speciation methods, alone with the corresponding discussion on biometal(loid) sciences. Not only the scientists who are engaging in Metallomics study but also newcomers who want to do research on Metallomics will benefit from reading this book" Qiuquan Wang on behalf of Springer, 31/07/2017
