Microreactors in Preparative Chemistry: Practical Aspects in Bioprocessing, Nanotechnology, Catalysis and more

This is the first book in the field to focus on these aspects, providing extremely valuable information unavailable elsewhere for anyone seeking the practical application of microreactor technology in preparative chemistry. The topics covered branch out in three different directions. To begin with, the knowledge necessary for the preparative chemistry concerning the influence of the so-called microeffects on the reaction procedure and on mass and heat transfer as well as the surface phenomena are provided in detail. Next, practical aspects of the synthesis of various basic chemicals and fine chemicals, polymers, bioproducts and nanoparticles are discussed, including important advice for both the researcher and industrial chemist. Finally, reaction examples in microreactors whose reaction guidance are best understood are given together with universally applicable correlations as well as modeling approaches and transfer potential on related reaction systems. With its specific instructions, tips and experimental procedures for product syntheses as well as the inclusion of both the technical and theoretical background this is a must-have for beginners and experts alike working in this emerging field.

Table of Contents:
PREFACE PRINCIPLES OF MICROPROCESS TECHNOLOGY Introduction History Basic Characteristics Industrial Applications Concluding Remarks EFFECTS OF MICROFLUIDICS ON PREPARATIVE CHEMISTRY PROCESSES Introduction Mixing Heat Management Mass Transfer and Chemical Reactions Flow Separation Numbering-Up Strategy Practical Exercise: Experimental Characterization of Mixing in Microstructured Reactors MODULAR MICRO- AND MILLIREACTOR SYSTEMS FOR PREPARATIVE CHEMICAL SYNTHESIS AND BIOPROCESSES Introduction Modular Microreaction System Examples for Microreactor Applications Laboratory Exercise: Suzuki Reaction in a Modular Microreactor Setup POTENTIAL OF LAB-ON-A-CHIP: SYNTHESIS, SEPARATION, AND ANALYSIS OF BIOMOLECULES Introduction Learning from Nature: Analogies to Living Cells Microenzyme Reactors Microchip Electrophoresis Microenzyme Membrane Reactor/Micromembrane Chromatography Nucleic Acid Analysis in Microchannels Saccharide Analyses in Microdevices Practical Exercise: Lipase-Catalyzed Esterification Reaction BIOPROCESSING IN MICROREACTORS Introduction Background Practical Exercise: Functionalization of Silicon Surface SYNTHESIS OF FINE CHEMICALS Introduction Organic Synthesis in Liquid and Liquid - Liquid Phases Gas - Liquid Biphasic Organic Synthesis Practical Exercise: Photochemical Generation of Singlet Oxygen and Its [4 + 2] Cycloaddition to Cyclopentadiene SYNTHESIS OF NANOMATERIALS USING CONTINUOUS-FLOW MICROREACTORS Introduction Microfluidic Devices Synthesis of Nanomaterials Using Microreactors Kinetic Studies Process Optimization Point-of-Use Synthesis and Deposition Practical Exercises: Synthesis of Nanocrystals POLYMERIZATION IN MICROFLUIDIC REACTORS Introduction Practical Considerations Single-Phase Polymerization Multiphase Polymerization Beyond Synthesis: New Developments for Next-Generation MF Polymerization Practical Exercise: MF Polymerization Reactor Kinetics Studies Using In Situ Characterization ELECTROCHEMICAL REACTIONS IN MICROREACTORS Introduction Electrode Configuration Electrolysis without Supporting Electrolytes Generation and Reactions with Unstable Intermediates Practical Exercise: Electrochemical Reactions in Flow Microreactors HETEROGENEOUS CATALYSIS IN MICROREACTORS Introduction Bulk Catalysts Supported Catalysts Mesoporous Supports Microporous Supports Practical Exercise: PdZn/TiO2-Catalyzed Selective Hydrogenation of Acetylene Alcohols in a Capillary Microreactor CHEMICAL INTENSIFICATION IN FLOW CHEMISTRY THROUGH HARSH REACTION CONDITIONS AND NEW REACTION DESIGN Introduction High-Temperature Processing in Microflow High-Pressure Processing in Microflow Solvent Effects in Microflow Ex-Regime Processing and Handling of Hazardous Compounds in Microflow New Chemical Transformations in Microflow Process Integration in Microflow Practical Exercises MODELING IN MICROREACTORS Introduction Processes in Microreactors and the Role of Mixing Modeling of Processes in Microreactors Based on General Balance Equation Computation of Reaction Flows in Microreactors Practical Exercise: Alkylation of Phenylacetonitrile INDEX

About the Author :
Wladimir Reschetilowski is Director of the Institute of Industrial Chemistry at the University of Technology Dresden, Germany. Having obtained his academic degrees from Technical University Leuna-Merseburg, he began his career working at the Leipzig University, continued it for DECHEMA (Society for Chemical Engineering and Biotechnology, Frankfurt/M.) as the Head of the Department of Technical Chemistry before taking up his present appointment as Full Professor at the University of Technology Dresden. Professor Reschetilowski has authored over 200 scientific publications in the field of acid and bifunctional catalytic conversion of hydrocarbons by microporous and mesoporous solids, asymmetric synthesis on chiral-modified catalyst systems, application of microstructured reactors in preparative chemistry and catalytic conversion of bio-based raw materials into organic base products and fuels. He is awarded with an honorary professorship by St.-Petersburg State University of Technology and is known as the principal author of the compendium 'Academic curriculum of teaching technical chemistry' in German Universities as well as of the teaching book 'Technisch-chemisches Praktikum'. He is also appointed expert of the accreditation agency in engineering, computer sciences, natural sciences and mathematics (ASIIN).