Cellular and Biomolecular Recognition: Synthetic and non-Biological Molecules

With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.

Table of Contents:
DEVELOPMENT OF FUNCTIONAL MATERIALS FROM ROD-LIKE VIRUSES Introduction Overview Programmable Protein Shells Templated Syntheses of Composite Materials Self-Assembly of Rod-Like Viruses Virus-Based Device and Applications Outlook BIOMIMETIC NANOPARTICLES PROVIDING MOLECULARLY DEFINED BINDING SITES - PROTEIN-FEATURING STRUCTURES VERSUS MOLECULARLY IMPRINTED POLYMERS Introduction Core Materials and Functionalities Functional Shells Applications Products Conclusions INTERACTION BETWEEN SILICA PARTICLES AND HUMAN EPITHELIAL CELLS: ATOMIC FORCE MICROSCOPY AND FLUORESCENCE STUDY Interaction of Silica with Biological Cells: Background Interaction of Silica Particle with the Cell Surface: How it is Seen with AFM Ultra-Bright Fluorescent Silica Particles to be Used to Study Interaction with Cells Ultra-Bright Fluorescent Silica Particles to Distinguish Between Cancer and Normal Cells CHIRAL MOLECULAR IMPRINTING AS A TOOL FOR DRUG SENSING Introduction Electrochemical Drug Sensors Optical Drug Sensors Mass Drug Sensors CATALYTIC ANTIBODIES FOR SELECTIVE CANCER CHEMOTHERAPY Introduction Catalytic Antibodies Designed for Prodrug Activation Catalytic Antibody 38C2 and Cancer Therapy Chemically Programmed Antibodies NATURAL AND SYNTHETIC STIMULATORS OF THE IMMUNE RESPONSE Introduction Lipopolysaccharide Endotoxin - A Potent Immunostimulatory Molecule LPS Recognition Septic Shock LPS Biosynthesis Minimal Modified Lipid A Isolation of "Natural" Kdo2-Lipid A Synthetic LPS, Lipid A and Their Uses Structural Studies Bacterial LPS-Binding Proteins Sphingolipids - Essential Membrane Components of Mammals, Plants, Fungi, Yeast and Bacteria Natural Killer T Cells and GSLs GSL Antigens Structure - Activity Relationships Saccharide Modification Ceramide Modification High-Resolution Structural Analysis of Receptor-GSL Complexes SUPRAMOLECULAR ASSEMBLIES OF POLYDIACETYLENES FOR BIOMOLECULAR SENSING: COLORIMETRIC AND "TURN-ON" FLUORESCENCE APPROACHES Introduction Vesicular PDA Sensors for Colorimetric Signaling of Bacterial Pore-Forming Toxin Fabrication of "Turn-On" Fluorescence Vesicle Sensors with PDAs "Mix-and-Detect" Type of "Turn-On" Fluorescence Sensor for Bacterial Toxin MULTIVALENT SYNTHETIC RECEPTORS FOR PROTEINS Aminopyrazoles for Beta-Sheet Capping in Protein Misfolding Events New Mechanisms of Enzyme Inhibition by Molecular Clips and Tweezers Protein Surface Recognition by Tailor-Made Polymers ANALYSIS OF BIOLOGICAL INTERACTIONS AND RECOGNITIONS BY SURFACE PLASMON RESONANCE Introduction to Surface Plasmon Resonance Technology Working Principle of SPR Sensor Surface Chemistry and Its Fabrications Important Factors Impacting on the Performance of SPR-Based Analyses of Biological Interactions on the Nonbiological Transducer Surface Localized SPR of Inorganic Nanoparticles for Analyses of Biological Interaction MEMBRANE-ACTIVE NATURAL AND SYNTHETIC PEPTIDES AND PEPTIDOMIMETICS Introduction Mode of Action of Membrane-Active Peptides Natural Peptides Synthetic Peptides Peptidomimetics LUMINESCENT QUANTUM DOT FLUORESCENCE RESONANCE ENERGY TRANSFER-BASED PROBES IN CELLULAR AND BIOLOGICAL ASSAYS Introduction Luminescent QDs FRET QD FRET-Based Protease Probes NEW PROTEINS FOR NEW SENSING METHODOLOGIES: THE CASE OF THE PROTEIN-BINDING FAMILY Introduction Galactose/Glucose-Binding Protein from Escherichia Coli Glutamine-Binding Protein from E. Coli Trehalose/Maltose-Binding Protein from the Hyperthermophilic Archaeon Thermococcus Litoralis Lipocalins and Odorant-Binding Protein METHODS OF ANALYSIS FOR IMAGING AND DETECTING IONS AND MOLECULES Fluorescent and Luminescent Proteins Functional Peptides Representative Technologies for Molecular Imaging

About the Author :
Currently at the department of chemistry at Ben Gurion University, Israel, Raz Jelinek obtained his BSc in chemistry from the Hebrew University of Jerusalem, Israel, and his PhD from the University of California, Berkeley. He was a Cancer Research Institute post-doctoral fellow at the University of Pennsylvania, and is currently a Visiting Professor at the Department of Chemical and Biomolecular Engineering at Johns Hopkins University. Professor Jelinek has over 80 scientific publications and 10 patents to his name, and has received several scientific awards, including the Roger-Siegel-Brown Award of the Israeli Academy of Science and the Ruth L. Kirschstein National Research Service Award of the National Institutes of Health, USA.

Review :
“The various contributors to this book provide novel experimental approaches and insights toward biomolecular recognition in biological systems.” (JACS Reviews, 2010)