Molecular Imprinting: From Fundamentals to Applications

Molecular imprinting, the polymerization of monomers in the presence of a template molecule which imprints structural information into the resulting polymers, is a scientific field which is rapidly gaining significance for a widening range of applications in biotechnology, biochemistry and pharmaceutical research. The methods and tools needed to distinguish target molecules from others by means of tailor-made receptors are constantly growing in importance and complexity. This book gives a concise and highly up-to-date overview of the remarkable progress made in this field in the last five years. The material is comprehensively presented by the authors, giving a thorough insight into fundamentals and applications for researchers in both industry and academy.

Table of Contents:
Preface INTRODUCTION Importance of Receptor Molecules in Advanced Science and Technology Naturally Ocurring Receptors Artificial Receptors Receptors for Practical Applications Why is the Molecular Imprinting Method so Promising? FUNDAMENTALS OF MOLECULAR IMPRINTING Introduction General Principle of Molecular Imprinting Covalent Imprinting and Non-covalent Imprinting Advantages and Disadvantages of Covalent and Non-Covalent Imprinting History EXPERIMENTAL METHODS (I) - PROCEDURES OF MOLECULAR IMPRINTING Introduction Reagents and Experimental Procedures Covalent Imprinting Non-covalent Imprinting "Dummy Molecular Imprinting" EXPERIMENTAL METHODS (II) - EVALUATION OF IMPRINTING EFFICIENCY Chromatographic Experiments Batchwise Guest-Binding Experiments Determination of Guest-Binding Constants SPECTROSCOPIC ANATOMY OF MOLECULAR IMPRINTING REACTIONS Introduction Structures of Adducts in the Pre-organization Step Determination of the Binding Constant K for the Formation of Monomer-Template Adduct Relationship between K Value and Imprinting Efficiency Structure of the Guest-Binding Site FLOW-CHART OF A TYPICAL MOLECULAR IMPRINTING Introduction Choice of Agents Polymerization Packing of Imprinted Polymers into the HPLC Columns Quantitative Evaluation of Imprinting Efficiency APPLICATIONS OF MOLECULARLY IMPRINTED POLYMERS Introduction Sensor Applications Signaling Polymers Molecularly Imprinted Sorbent Assays Molecularly Imprinted Membranes Affinity-based Solid-phase Extraction Molecularly Imprinted Catalysts RECENT CHALLENGES AND PROGRESS Introduction Molecular Imprinting in Water Use of Two Kinds of Functional Monomers for Cooperative Recognition Inorganic Gel as the Matrix for Molecular Imprinting Artificial Enzyme (Molecular Catalyst) by Molecular Imprinting Catalytic Antibody Prepared by Using Transition-State Analog CONCLUSIONS AND PROSPECTS Index

About the Author :
Dr. Makoto Komiyama is Assistant Professor of Chemistry at the University of Tokyo. Among his awards is the Chemical Society of Japan Award for Young Chemists. Dr. Komiyama's research interests include cyclodextrin chemistry, functionalized polymer chemistry, and molecular complex chemistry. He received his BA and PhD degrees in chemistry from the University of Tokyo. Makoto Komiyama is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley. Takashi Mukawa is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley. Hiroyuki Asanuma is the author of Molecular Imprinting: From Fundamentals to Applications, published by Wiley.

Review :
"Dieses kurze Lehrbuch ist allen interssierten Studierenden zu empfehlen, sei es als Einzellekture oder als Kurs-begleitendes Buch. Neulinge, die in dieses Forschungsgebiet einsteigen wollen, werden es als Einfuhrung zu schatzen wissen..." Angewandte Chemie