Hansenula polymorpha
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Hansenula polymorpha: Biology and Applications

Hansenula polymorpha: Biology and Applications


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About the Book

Methylotrophic yeasts have attracted increasing interest as useful systems for fundamental research and applied purposes. Hansenula polymorpha in particular has become a preferred organism for the production of recombinant proteins on an industrial scale. Product examples range from therapeutics such as hepatitis B vaccines to industrial enzymes like the feed additive phytase. This book is addressed to researchers and scientists working in the field and provides a comprehensive, up-to-date overview of the present status of Hansenula polymorpha research, applications and methods. Aspects of the organism ranging from systematics, genetics, methanol metabolism and peroxisomal function to its use as a technology platform for the production of recombinant proteins are covered. A detailed chapter on laboratory methods is also included.

Table of Contents:
History, habitat, variability, nomeclature and phylogenetic position of Hansenula polymorpha Basic genetics of Hansenula polymorpha Biochemistry and genetics of nitrate assimilation Amino acid biosynthesis Methanol metabolism Hansenula polymorpha: a versatile model organism in peroxisome research Characteristics of the Hansenula polymorpha genome The expression platform based on Hansenula polymorpha strain RB11 and its derivatives - history, status and perspectives Development of expression systems for the production of recombinant proteins in Hansenula polymorpha DL-1 Foreign gene expression in Hansenula polymorpha - approaches for "difficult proteins" Fermentation and primary product recovery Recombinant hepatitis B vaccines - disease characterization and vaccine production Production of anticoagulants in Hansenula polymorpha Production of cytokines in Hansenula polymorpha Technical enzyme production and whole-cell biocatalysis: application of Hansenula polymorpha Biosafety aspects of genetically engineered Hansenula polymorpha - a case study about non-deliberate environmental releases Methods Appendix

Review :
"...beginning with excellent introductory information and building to complicated issues...this book presents a nice balance of current uses and realistic applications...that provides something for everyone and is clearly a very useful text..." (Pharmaceutical Research, Vol. 20, No. 6, June 2003) "...a superb book...a bible for those who work in the field, a great introduction for those thinking of moving in..." (Yeast, Vol 20(5), Nov 2003)


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Product Details
  • ISBN-13: 9783527614462
  • Publisher: John Wiley and Sons Ltd
  • Publisher Imprint: Wiley-VCH Verlag GmbH
  • Language: English
  • Sub Title: Biology and Applications
  • ISBN-10: 352761446X
  • Publisher Date: 01 May 2017
  • Binding: Digital (delivered electronically)
  • No of Pages: 365


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