Polymorphism: In the Pharmaceutical Industry

Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries. With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.

Table of Contents:
Relevance of Solid-state Properties for Pharmaceutical Products Thermodynamics of Polymorphs Characterization of Polymorphic Systems using Thermal Analysis Solid-state NMR Spectroscopy Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization Crystallography for Polymorphs Light Microscopy The Importance Solvates Physical Characterization of Hygroscopicity in Pharmaceutical Solids The Amorphous State Approaches to Polymorphism Screening Salt Selection Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality Polymorphism and Patents from A Chemist's Point of View Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications

About the Author :
After gaining his PhD in physical chemistry from Basel University, Switzerland, Rolf Hilfiker did his postdoc at Stony Brook, USA. He returned to Basel as a research fellow, initially at the university and then at Ciba-Geigy. In 1997 he became head of Stability & Kinetics group at Novartis, joining Solvias two years later where he is currently head of the department Solid-State Development. Dr. Hilfiker has taught physical chemistry in New York and Basel, and is a recipient of the Jacottet-Kung Award and a Treubel Fellowship. He is author of more than 50 scientific publications in various areas of physical chemistry.

Review :
"...ist dem Buch ein grosser Leserkreis zu wunschen, und vor allem fur Studierende wird die Lekture ein grosser Gewinn sein, da in den meisten Grundvorlesungen der Chemie das Thema Polymorphie ausgelassen wird. Daruber hinaus ist es Wissenschaftlern in der pharmazeutischen Industrie und an Hochschulen, die sich fur die Charakterisierung organischer Festkorper interessieren, sehr zu empfehlen." Angewandte Chemie