Biological Reaction Engineering – Dynamic Modelling Fundamentals with Simulation Examples 2e

In this book, the modelling of dynamic biological engineering processes is presented in a highly understandable way using the unique combination of simplified fundamental theory and direct hands-on computer simulation. The mathematics is kept to a minimum, and yet the 60 examples supplied on a CD-ROM illustrate almost every aspect of biological engineering science. Each example is described in detail, including the model equations. The programs are written in the modern user-friendly simulation language Berkeley Madonna, which can be run on both Windows PC and Power-Macintosh computers. Madonna solves models comprising many ordinary differential equations using very simple programming, including arrays. It is so powerful that the model parameters may be defined as "sliders", which allow the effect of their change on the model behavior to be seen almost immediately. Data may be included for curve fitting, and sensitivity or multiple runs may be performed. The results can be seen simultaneously on multiple-graph windows or by using overlays. The examples can be varied to fit any real situation, and the suggested exercises provide practical guidance. The extensive experience of the authors, both in university teaching and international courses, is reflected in this well-balanced presentation, which is suitable for the teacher, the student, the biochemist or the engineer.

Table of Contents:
PART I PRINCIPLES OF BIOREACTOR MODELLING MODELLING PRINCIPLES Fundamentals of Modelling Development and Meaning of Dynamic Differential Balances Formulation of Balance Equations BASIC BIOREACTOR DESIGN Information Inputs Bioreactor Operations BIOLOGICAL KINETICS Enzyme Kinetics Simple Microbial Kinetics Structured Kinetic Models BIOREACTOR MODELLING General Balances for Tank type Biological Reactors Modelling Tubular Plug Flow Bioreactors MASS TRANSFER Mass Transfer in Biological Reactors Interphase Gas Liquid Mass Transfer General Oxygen Balances for Gas Liquid Transfer Models for Oxygen in Large Scale Bioreactors DIFFUSION AND BIOLOGICAL REACTION IN IMMOBILIZED BIOCATALYST SYSTEMS External Mass Transfer Internal Diffusion and Reaction within Biocatalysts AUTOMATIC BIOPROCESS CONTROL FUNDAMENTALS Elements of Feedback Control Types of Controller Action Controller Tuning Advanced Control Strategies Concepts for Bioprocess Control REFERENCES PART II DYNAMIC BIOPROCESS SIMULATION EXAMPLES AND THE BERKELEY MADONNA SIMULATION LANGUAGE SIMULATION EXAMPLES OF BIOLOGICAL REACTION PROCESSES USING BERKELEY MADONNA Introductory Examples Batch Reactors Fed Batch Reactors Continuous Reactors Oxygen Uptake Systems Controlled Reactors Diffusion Systems Multi Organism and Structured Models Animal Cell Reactor Examples APPENDIX: USING THE BERKELEY MADONNA LANGUAGE