Cellular Proteins and Their Fatty Acids in Health and Disease

In light of the increasing importance of these proteins and their ligands for our understanding of cellular growth, differentiation, and development, as well as of diseases such as obesity, insulin resistance, atherosclerosis, cancer, and inflammation, a team of internationally renowned editors and authors have compiled here the very first comprehensive book on these topics. They describe fatty acid-activated transcription factors as well as membrane and soluble fatty acid transporters, covering such aspects as structure and function, lipid-protein interaction, delivery of ligands, and the roles of these proteins in gene expression pertaining to the homeostatic and diseased states of cells and organs. Incorporating recent findings, this is indispensable for basic scientists, health professionals in industry and clinics as well as postgraduate students.Contributors among others include: N.A. Abumrad, J.E. Schaffer, G. Schmitz, N.J. Brunskill, J. Storch, U. Seedorf, S. Mandrup, C.N.A. Palmer, T. Perlmann, H.I. Nebb, J. Bar-Tana, H. Kondo, C. Wolfrum, C. Kerkhoff , S. Farmer, E.J. Murphy, J.F.C. Glatz, P. Besnard, J.M. Stewart, A. Meirhaeghe, J. Plutzky, W. Wahli and R.A. Roberts.

Table of Contents:
PART 1 - THE MOLECULAR BASIS OF PROTEIN-LIPID INTERACTION AND FUNCTIONAL CONSEQUENCES 1 Structure-function of CD36 and evidence for its role in facilitating membrane fatty acid transport 2 Role and function of FATPs in fatty acid uptake 3 Function, expression and regulation of human ABC Transporters 4 Albumin receptors - structure and function 5 Intracellular lipid binding proteins: evolution, structure and ligand binding 6 Fatty acid binding proteins and fatty acid transport 7 Structure and function of sterol carrier protein-2 8 Structure, function and phylogeny of Acyl-CoA binding protein 9 Structure and function of PPARs and their molecular recognition of fatty acids 10 Structure and function of retinoid receptors RAR and RXR 11 LXRs: Important regulators of lipid homeostasis 12 Acyl-CoA ligands of HNF-4 and HNF-4a/PPARa interplay PART2 - ROLE FOR PROTEINS IN CELLULAR HOMEOSTASIS 13 Fatty acid binding proteins and their roles in transport of long-chain polyunsaturated fatty acids across the feto-placental unit 14 Fatty acid binding proteins of the brain 15 Cross-talk between intracellular lipid binding proteins and ligand activated nuclear receptors - a signalling pathway for fatty acids 16 Arachidonic acid binding proteins in human neutrophils 17 PPARs, cell differentiation and glucose homeostasis 18 Role of FABPs in cellular phospholipid metabolism 19 Membrane-associated fatty acid binding proteins regulate fatty acid uptake by cardiac and skeletal muscle 20 Intestinal fat absorption: Roles of intracellular lipid-binding proteins and peroxisome proliferator-activated receptors 21 Fatty acid binding proteins as metabolic regulators 22 Role of fatty acid transport/binding proteins in diseases 23 PPARs and atherosclerosis 24 PPARs: Nuclear hormone receptors involved in the control of inflammation 25 PPARs and cancer