Biomaterials Effect on the Bone Microenvironment
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Biomaterials Effect on the Bone Microenvironment: Fabrication, Regeneration, and Clinical Applications

Biomaterials Effect on the Bone Microenvironment: Fabrication, Regeneration, and Clinical Applications


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About the Book

Biomaterials Effect on the Bone Microenvironment Practical resource on clinical bone regeneration from a variety of related interdisciplinary researchers Biomaterials Effect on the Bone Microenvironment focuses on the structure-activity relationship between bone biomaterials and microenvironment regulation, presenting a systematic exposition from all aspects of biomaterials regulated microenvironment in bone regeneration and covering design strategies, applications, and mechanisms of biomaterials that regulate bone microenvironment, along with the methods for manufacturing biomaterials and their clinical translation. The subject’s potential challenges and future development direction are discussed, and the design and initiative principle of tailored biomaterials with various features, including bioactive components and physicochemical property, are elucidated in depth. Numerous biomaterials, including natural and synthetic, are summarized and compared. Their advantages and features are also evaluated, particularly in bone microenvironmental regulation and bone generation. Moreover, the stimulation mechanism of the microenvironment to bone generation is discussed in detail, including mechanical-support effect, redox effect, pro-angiogenesis effect, inflammatory immune effect, and anti-aging effect. Biomaterials Effect on the Bone Microenvironment provides further coverage of sample topics such as: Role of bone microenvironment and its associated biomaterials in modulation bone diseases, reviewing the biomaterials used to regulate bone microenvironment Relationship between biological factors of various materials and physiological functions in bone microenvironment Application of the third generation of biomaterials, which would regenerate the bone to regulate bone microenvironment Emerging biological material manufacturing technology and mechanisms of novel biomaterial modulating microenvironment for bone regeneration Future outlook of bone tissue engineering along with the general process of bone remodeling and regeneration With comprehensive coverage of one of the most promising and valuable candidates for clinical bone regeneration, Biomaterials Effect on the Bone Microenvironment is an ideal resource for materials scientists, biotechnologists, biochemists, bioengineers, orthopedists, and clinical chemists who want to stay on the cutting edge of this rapidly evolving field.

Table of Contents:
Preface ix 1 Bone Microenvironment 1 Yingying Jing and Xiao Chen 1.1 Introduction 1 1.2 Bone Microenvironment and Diseases 9 1.3 Biomaterials and Bone Microenvironment 18 2 Materiobiological Effects Regulate the Bone Microenvironment 43 Shuangshuang Chen 2.1 Bioactive Components Influence the Bone Microenvironment 44 2.2 Physicochemical Property Influence the Bone Microenvironment 59 3 Design and Application of Biomaterials to Regulate Microenvironment for Bone Regeneration 75 Xiuhui Wang and Yingying Jiang 3.1 Natural Biomaterials for Bone Microenvironment Regulation 76 3.2 Synthetic Biomaterials for Bone Microenvironment Regulation 87 4 Fabrication Technologies of Biomaterials 107 Qin Zhang and Xue Xu 4.1 Fabrication Technologies of Biomaterials 107 4.2 Fabrication Technologies of Hydrogels 114 4.3 Fabrication Technologies of Other Biomaterials 121 References 125 5 Mechanisms for Biomaterials Reconstruct Microenvironment in Bone Regeneration 129 Yan Wei and Mengmeng Li 5.1 Mechanical Support Effect 129 5.2 Redox Effect 133 5.3 Pro-angiogenesis Effect 138 5.4 Inflammatory Immune Effect 144 5.5 Anti-Aging Effect 149 6 Biomaterials Regulating Bone Microenvironment in Clinical Application 157 Zhen Geng, Xiaoxiang Ren, and Sicheng Wang 6.1 Introduction 157 6.2 Autogenous Bone Remodeling 158 6.3 Allogeneic Bone Regeneration 161 6.4 Clinical Effect of Biomaterials 165 6.4.1 Bone tissue engineering 168 6.5 Clinical Challenges and Opportunities 169 References 170 7 Conclusions and Perspectives 175 Ke Xu, Yan Hu, and Han Liu 7.1 Bone Microenvironment Under Physiological and Pathological Conditions 175 7.2 Biological Effects Under Modulation of Materials 177 7.3 Design and Application of Biomaterials in Bone Regeneration 178 7.4 Fabrication Technologies 180 7.5 Microenvironment Under Biomaterial Regulation 181 7.6 Biomaterials in Clinical Experience 182 Index 185

About the Author :
Jiacan Su is the Department Head of Institute of Translational Medicine, Shanghai University, Shanghai and chief physician of Orthopedics Department, Shanghai Changhai Hospital, Second Military Medical University, Shanghai. Professor Su received his bachelor’s degree (1999) and M.D. (2004) from Second Military Medical University. Xiao Chen, Associate Professor, Department of Orthopedics, Shanghai Changhai Hospital, China. Yingying Jing, Assistant Professor, Institute of Translational Medicine, Shanghai University, China.


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Product Details
  • ISBN-13: 9783527350438
  • Publisher: Wiley-VCH Verlag GmbH
  • Publisher Imprint: Blackwell Verlag GmbH
  • Height: 244 mm
  • No of Pages: 208
  • Returnable: N
  • Sub Title: Fabrication, Regeneration, and Clinical Applications
  • Width: 170 mm
  • ISBN-10: 3527350438
  • Publisher Date: 08 Feb 2023
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Spine Width: 16 mm
  • Weight: 567 gr


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