Antibacterial Drug Discovery and Development - Bookswagon UAE
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Antibacterial Drug Discovery and Development

Antibacterial Drug Discovery and Development


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About the Book

This comprehensive reference surveys current approaches to novel antibacterials along the entire drug discovery and development value chain. It includes case studies and a wide range of innovative approaches that go beyond classical small molecule drugs.

Table of Contents:
PART I: OVERVIEW Overview of Antibacterials The Research Pipeline The Clinical Pipeline Surveillance PART II: UNDEREXPLORED TARGETS Old Targets New Targets PART III: TRANSLOCATION The Porin Approach MedChem Beyond Lipinski Permeability, Efflux and Cell Penetration PART IV: PHARMAKOKINETICS AND PHARMAKODYNAMICS Prediction of Human Doses Allometric Scaling PART V: INNOVATIVE PLATFORMS Microbiome-based Approaches Beneficial Bacteria in Dermatology Functional RNA Anti-Toxins Alpharmers Endolysins AMP CRISPR-based Bacteriophages PART VI: NATURAL PRODUCTS REVIVAL Untapped Sources Genome Mining, Gene Editing, and Silent Operons PART VII: INNOVATIVE APPROACHES TO TACKLE ANTIMICROBIAL RESISTANCE Synthetic Biology Diversity-oriented Synthesis Machine Learning to Explore Novel Spaces Microfluidic Assays Flow Chemistry PART VIII: CLINICAL TRIALS Current Limitations in Trial Design Adaptive Trial Design Paediatric Trials Pathogen-specific Trials PART IX: CASE STUDIES Xenleta (Lefarmulin) Fetroia (Cefiderocol) Zimdi (Plazomicin)

About the Author :
Cuong Vuong is currently the Director of Research Bacteriology at AiCuris Anti-infective Cures, based in Wuppertal (Germany). He obtained his academic degrees from the University of Tuebingen (Germany) and worked at the U.S. National Institute of Allergy and Infectious Diseases before accepting a post as Assistant Professor at the University of Massachusetts Medical School in 2005. His research focuses on antibacterial drug discovery for multi-drug resistant pathogens, virulence mechanisms and animal infection models.


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Product Details
  • ISBN-13: 9783527350414
  • Publisher: Wiley-VCH Verlag GmbH
  • Publisher Imprint: Wiley-VCH Verlag GmbH
  • Height: 244 mm
  • No of Pages: 750
  • Returnable: N
  • ISBN-10: 3527350411
  • Publisher Date: 03 Jan 2024
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Width: 170 mm


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