Chromatography in Organic Synthesis

This first book to present chromatography as an integral part of organic synthesis covers such topics as the synthesis of chromatographic stationary phases, as well as chromatographic analysis and preparative chromatography in support of organic chemistry research. As a result, readers learn how organic synthesis can be improved using chromatographic methods. Edited by an internationally renowned and leading research chemist in the field and with many authors from industry contributing information that is otherwise unavailable, this is a highly useful tool for both practicing chromatographers and synthetic chemists.

Table of Contents:
INTRODUCTION SYNTHESIS OF CHROMATOGRAPHIC STATIONARY PHASES Overview of synthetic strategies for preparation of new chromatographic stationary phases Synthesis of Oligosaccharide-based stationary phases Synthesis of Novel Chiral Stationary Phases based on cyclodextrins, antibiotics, and other materials Stationary phase syntheis Synthesis of crown-ether based chromatographic stationary phases CHROMATOGRAPHIC ANALYSIS IN SUPPORT OF ORGANIC CHEMISTRY RESEARCH Use of chromatographic analysis to support research in organic chemistry High throughput chromatographic analysis in support of high throughput experimentation in organic chemistry New concepts for high throughput catalysis screening using chromatography High speed chromatography for high throughput enzyme screening PREPARATIVE CHROMATOGRAPHY IN SUPPORT OF ORGANIC CHEMISTRY RESEARCH High throughput mass-directed chromatographic purification in support of medicinal chemistry research Integrated small scale high throughput chromatographic purification to support synthetic chemistry research Preparative chromatography in support of pharmaceutical process research - grams to kilos Strategic use of preparative chromatography in organic synthesis Preparative Chromatography at Industrial Scale

About the Author :
Dr. Chris Welch is a senior research fellow at Merck & Co., Inc. in the department of Process Research. His research involves the use of analysis and separations tools to support pharmaceutical development, with special emphasis on stereochemical issues. Current work focuses on two major areas: 1) rapid and high throughput analysis techniques involving HPLC, SFC, MS and chiroptical detection. 2) preparative chromatographic separations and other purification technologies, including the use of the `green? technique of supercritical fluid chromatography (SFC) for carrying out kilogram scale purifications. Before joining Merck, he worked at Regis Technologies and Abbott Laboratories. He obtained his Ph.D. from the University of Illinois under the direction of Prof. William Pirkle.