Chemical Biology: Learning through Case Studies

This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. The editor's extensive experience in writing textbooks and his close relationship to the authors ensure that the contributions are presented in a pedagogically uniform and highly motivating fashion. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to think in order to solve problems in biology by using techniques and tools taken from chemistry. A must-have for students in chemistry, biology and biochemistry.

Table of Contents:
YEAST-BASED CHEMICAL GENOMIC APPROACHES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation - Chemogenomic Profiling: Elucidating the Mode of Action of Small Molecules MIRCOARRAY-BASED STRATEGIES TO IDENTIFY UNKNOWN PROTEIN INTERACTIONS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation COMPOUND COLLECTION SYNTHESIS FOR CHEMICAL BIOLOGY Introduction Chemical Probes - A Chemical Question with Biological Consequences Diversity Oriented Synthesis (DOS) Biology Oriented Synthesis (BIOS) TARGET IDENTIFICATION AND VALIDATION OF A WNT/BETA-CATENIN PATHWAY MODULATOR Introduction Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation ACTIVITY-BASED PROTEIN PROFILING OF CYS PROTEASES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE USE OF PHOTOAFFINITY LABELING FOR THE IDENTIFICATION OF THE BINDING SITE OF THE ANTIBIOTIC LINEZOLID Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation SURGICAL STRIKES: USES OF ANALOG SENSITIVE TECHNOLOGIES TO TARGET KINASES OF INTEREST Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation: ASKA Technology - Applications in Molecular Biology MODULATION OF PROTEIN-PROTEIN INTERACTIONS BY SMALL MOLECULES Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation TARGETED PROTEIN DEGRADATION IN LIVE CELLS Introduction The Biological Problem The Chemical Approach TRAPOXIN B: FROM TOTAL SYNTHESIS TO EPIGENETICS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation NATIVE CHEMIAL LIGATION - A TOOL FOR CHEMICAL PROTEIN SYNTHESIS Introduction The Synthetic Challenge The Chemical Approach - Native Chemical Ligation Chemical Biological Research/Evaluation - The Ras-RBD Systems USING SPLIT INTEINS TO PREPARE SEMI-SYNTHETIC PROTEINS AND TO STUDY THE MECHANISMS OF PROTEIN TRANS-SPLICING Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation ELUCIDATION OF THE RAS CYCLE WITH SEMI-SYNTHETIC PROTEINS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE STUDY OF RAB GTPASE RECYCLING USING SEMI-SYNTHETIC PRENYLATED PROTEINS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation DEVELOPMENT OF A MODEL CANCER VACCINE CANDIDATE BASED ON THE MUCl CELLULAR SURFACE GLYCOPEPTIDE EPITOPE Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation THE INTRODUCTION OF CHEMICAL REPORTER GROUPS BY BIOORTHOGONAL LIGATION REACTIONS FOR THE IMAGING OF CELL-SURFACE GLYCANS Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation SEQUENCE SPECIFIC DNA-BINDING SMALL MOLECULES FOR PROTEIN RECRUITMENT AND MODULATION OF TRANSCRIPTION Introduction The Biological Problem - Targeting DNA with Small Molecules The Chemical Approach: The Polyamide Rationale Chemical Biological Research/Evaluation - Polyamides in Biological Applications G-QUADRUPLEX LIGANDS AS TOOLS FOR ELUCIDATING C-MYC TRANSCRIPTIONAL REGULATION Introduction The Biological Problem The Chemical Approach Chemical Biological Research/Evaluation

About the Author :
Herbert Waldmann obtained his PhD in organic chemistry from the University of Mainz in 1985 working with Professor Horst Kunz, after which he completed a postdoctoral appointment with Professor G. Whitesides at Harvard University. He was appointed as Professor of Organic Chemistry at the University of Bonn (1991), full Professor of Organic Chemistry at the University of Karlsruhe (1993), and Director at the MPI of Molecular Physiology Dortmund and Professor of Organic Chemistry at the University of Dortmund (1999). His research interests lie in the synthesis and use of small molecules in chemical biology research, the chemical biology of protein lipidation and protein microarrays. Petra Janning studied chemistry at the University of Munster, Germany, and did her PhD thesis at the Institute for Analytical Sciences in Dortmund (1995). After different positions where she worked in the area of analytical chemistry and on the borderline between chemistry and biology she joined the Max Planck Institute of Molecular Physiology, Dortmund, in the department of Professor H. Waldmann, where she is currently working. She is responsible for the bioorganic Practical Course and the analytics in the department. Her work is focused on the development of chromatographic and mass spectrometric methods used in the institute.

Review :
"This first book to adopt a problem-based approach teaches the true basics of the subject through illustrated everyday case studies. Each chapter introduces a different biological problem taken from everyday lab work, such that students learn how to solve problems in biology by using techniques and tools taken from chemistry." METALL (1/2 2010)