Handbook of Cyclization Reactions

The ultimate and only reference source in this field, this handbook discusses the latest advances on the reactions leading to the formation of cyclic structures and includes chapters presenting the most synthetically attractive cyclization reactions. Leading chemists from around the world provide authoritative first-hand information, including experimental procedures that offer readers valuable practical information that is otherwise unavailable. An aid for every organic chemist in grasping and applying these new reactions.

Table of Contents:
VOLUME 1: Preface ASYMMETRIC CATALYSIS OF DIELS-ALDER REACTION Introduction Asymmetric Diels-Alder Reaction Asymmetric Oxa-Diels-Alder Reaction Representative Applications in Total Synthesis Conclusion Experimental: Selected Procedures CATALYTIC ASYMMETRIC AZA DIELS-ALDER REACTIONS Introduction Chiral Lewis Acid Catalysis Chiral Organocatalysis Conclusion Experimental: Selected Procedures 1,3-DIPOLOAR CYCLOADDITION Introduction Nitrones Azomethine Ylides Azomethine Imines Carbonyl Ylides Nitrile Oxides and Nitrile Imines Diazo Compounds Conclusions Experimental: Selected Experimental INTRAMOLECULAR 1,2-ADDITION AND 1,4-ADDITION REACTIONS Introduction Cyclization via Intramolecular 1,2-Addition Reactions Cyclization via Intramolecular 1,4-Addition Reactions Conclusion and Perspectives Experimental: Selected Procedures CYCLIC CARBOMETALLATION OF ALKENES, ARENES, ALKYNES AND ALLENES Introduction Carbometallation of Alkenes Alkyne Carbometallation Carbometallations of Arenes Carbometallations of Allenes Multiple Cyclization Reactions Acylpalladations Conclusion Experimental: Selected Procedures TRANSITION METAL-CATALYZED INTRAMOLECULAR ALLYLATION REACTIONS Introduction Palladium-Catalyzed Intramolecular Allylation Reactions Iridium-Catalyzed Intramolecular Allylation Reactions Ni-Catalyzed Intramolecular Allylation Reactions Rh-Catalyzed Intramolecular Allylation Reactions Conclusion and Perspectives Experimental: Selected Procedures CYCLIC COUPLING REACTIONS Introduction Cyclic Coupling Involving Organoboron Cyclic Coupling Involving Organotin Cyclic Coupling Involving Organosilicon Cyclic Coupling Involving Amines or Alcohols Cyclic Coupling via the Heck Reaction Cyclic Coupling Involving Terminal Alkynes Conclusion and Perspectives Experimental: Selected Procedures TRANSITION METAL-MEDIATED [2+2+2]CYCLOADDITIONS Introduction Benzene Derivatives 1,3-Cyclohexadienes and their Heterocyclic Counterparts Cyclohexenes and their Heterocyclic Counterparts Conclusions and Perspectives Experimental: Selected Procedures CYCLIZATIONS BASED ON CYCLOMETALLATION Introduction Titanium-Catalyzed Cyclizations Zirconium-Catalyzed Cyclizations Ruthenium-Catalyzed Cyclizations Cobalt-Catalyzed Cyclizations Rhodium-Catalyzed Cyclizations Iridium-Catalyzed Cyclizations Nickel-Catalyzed Cyclizations Palladium-Catalyzed Cyclizations Conclusions and Perspectives Experimental: Selected Procedures TRANSITION METAL CATALYZED CYCLIZATION REACTIONS OF FUNCTIONALIZED ALKENES, ALKYNES, AND ALLENES Introduction Cyclization Reactions of Alkenes Cyclization Reactions of Alkynes Cyclization Reactions of Allenes Conclusion and Perspective Experimental: Selected Procedures RING-CLOSING METATHESIS OF DIENES AND ENYNES Introduction Ring-Closing Metathesis of Dienes Ring-Closing Metathesis of Enynes Perspective Experimental: Selected Procedure RING-CLOSING METATHESIS OF ALKYNES Introduction Alkyne Metathesis Ring-Closing Alkyne Metathesis as a Synthetic Strategy Catalyst Systems for Ring-Closing Alkyne Metathesis Complex Molecule Synthesis using Ring-Closing Alkyne Metathesis Ring-Closing Alkyne Metathesis within Transition Metal Coordination Spheres Cyclo Dimerizations, Trimerizations, and Oligomerizations Conclusions and Perspectives Experimental: Selected Procedures VOLUME 2 TRANSITION-METAL-CATALYZED CYCLOISOMERIZATIONS AND NUCLEOPHILIC CYCLIZATION OF ENYNES Introduction Cycloisomerizations of 1,n-Enynes Addition of Nucleophiles to 1,n-Enynes Skeletal Rearrangement of 1,n-Enynes Summary and Outlook Experimental: Selected Procedures CYCLOPROPANATION, EPOXIDATION AND AZIRIDINATION REACTIONS Introduction Cyclopropanation Epoxidations Aziridinations Experimental: Selected Procedures CYCLIZATION OF CYCLOPROPANE- OR CYCLOPROPENE-CONTAINING COMPOUNDS Introduction Cycloisomerization Reactions Cycloaddition Reactions Multicomponent Cyclization Reactions Cyclization Involving Miscellaneous and Cascade Reactions Experimental: Selected Procedures TRANSITION METAL-CATALYZED RING EXPANSION CYCLIZATION REACTIONS Introduction Palladium-Catalyzed Ring Expansions Ring Expansions with Other Transition Metals Conclusion Experimental: Selected Procedures HYDROMETALLATION-INITIATED CYCLIZATION REACTIONS Introduction Self-Feeding Cyclization Cyclization Tied by Outsourcing Reagents Cascade Reactions Incorporating CO Conclusion Experimental: Selected Procedures CATALYTIC DIPOLAR CYCLOADDITIONS OF ALKYNES WITH AZIDES AND NITRILE OXIDES Introduction Azide-Alkyne Cycloaddition: Basics Copper-Catalyzed Cycloadditions Ruthenium-Catalyzed Cycloadditions Experimental: Selected Procedures ELECTROPHILIC CYCLIZATIONS Introduction Mechanism, Regio- and Stereoselectivity Halocyclizations Selenocyclizations Conclusion and Perspectives Experimental: Selected Procedures CYCLIZATIONS BASED ON C-H ACTIVATION Introduction Aryl C-H Bond Activation Alkyl C-H Bond Activation Experimental: Selected Procedures FRIEDEL-CRAFTS TYPE CYCLIZATIONS Introduction Classic Intramolecular Friedel-Crafts Cyclizations RCFC Reactions via Activation of Carbonyl Derivatives and Alcohols RCFC Reactions of C-C Pi bonds Miscellaneous Reactions Catalytic Enantioselective RCFC Reactions Conclusion Experimental: Selected Procedures MACROLACTONES AND MACROLACTAMS Macrolactones Macrolactams Conclusion and Perspectives Experimental: Selected Procedures FREE RADICAL CYCLIZATION REACTIONS Radical Cyclizations: General Definition Different Methods for Radical Cyclizations Annulation Reactions Diastereoselective Radical Cyclization Enantioselective Radical Cyclization Applications of Radical Cyclizations in Natural Product Synthesis Experimental: Selected Procedures PHOTOCYCLIZATION REACTIONS Introduction Several Ways to Initiate Photocyclization Norrish Type II Initiated Reactions: H Transfer Photoinduced Electron Transfer Cyclizations Pi-Pi-Interactions Pi6-Photocyclization Experimental: Selected Procedures ASYMMETRIC ORGANOCATALYZED CYCLIZATION REACTIONS Introduction Enamine-Catalyzed Asymmetric Cyclization Reactions Iminium-Catalyzed Cyclization Reactions Sequential Catalysis with Chiral Amines for Domino Cyclization Reactions Bronsted Acid-Catalyzed Asymmetric Cyclization Reactions Lewis Base-Catalyzed Asymmetric Cycloadditions Asymmetric Cyclization Reactions by Bifunctional Catalysts Asymmetric Cyclizations Catalyzed by Chiral Nucleophilic Carbenes Conclusion Experimental: Selected Procedures

About the Author :
Shengming Ma is Professor of Chemistry at the Department of Chemistry, East China Normal University and the Director of State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC). After obtaining his Ph.D. from SIOC, he spent some time with Professors Venanzi (ETH Zurich, Switzerland) and Negishi (Purdue University, Indiana, USA) as a post-doctoral fellow and returned to China as a faculty member of SIOC in 1997. He has authored over 220 scientific publications and received numerous scientific awards including Mr. and Mrs. Sun Chan Memorial Award in Organic Chemistry and the OMCOS Award. He is also a member of the Chinese Academy of Sciences.

Review :
"Chemistry libraries should include Handbook of Cyclization Reactions in their holdings, as researchers at all levels will find it a useful resource. In this book, bench chemists will find direction to the appropriate primary literature needed to move their projects forward while research directors will find a valuable tool for proposal preparation and related amusements". (Journal of Medicinal Chemistry, 2010) "As editor, Shengming Ma has struck a good compromise in this respect, having limited himself to authors who present interesting new synthetic methods and strategies." (Organic Chemistry Portal, May 2010)