Phosphorus Ligands in Asymmetric Catalysis: Synthesis and Applications

With its list of contributors reading like a who's who, this is the ultimate standard reference on phosphorus in catalysis. Clearly divided into substance classes and spanning three volumes, it provides readers with an excellent introduction to the multitude of applications, backed by examples of optimal solutions. A definite must-have for all chemists working in synthetic chemistry, ranging from natural product synthesis to the production of pharmaceuticals.

Table of Contents:
Introduction TRIVALENT PHOSPHOROUS LIGANDS IN METAL-CATALYZED REACTIONS Chiral Monodentate Phosphorous Ligands Chiral Bidentate Phosphorous Ligands Chiral Polyphosphorous Ligands DYNAMIC PROCESSES OF P-LIGAND COMPLEXES Chiral Secondary Phosphine Oxides and Heteroatom-Substituted Secondary Phosphine Oxides as Preligands Catalysts with Chiral Self-Assembling P-Ligands P-Ligands with Additional Functional Groups - Concepts of Secondary Interactions and Hemilability CHIRAL LIGANDS FOR REACTIONS IN ALTERNATIVE MEDIA Ligands for Catalytic Reactions in Aqueous Systems Ligands for Catalytic Reactions in Fluorous Systems Ligands for Catalytic Reactions in Ionic Liquids Covalently Anchored P-Ligands and Catalysts Micelle-Based Chiral P-Ligands Dendritic Catalysts Based P-Ligands Noncovalently Anchored Catalysts Based on Chiral Phosphine Ligands P-LIGANDS BOUND TO BIOMOLECULES P-Ligands Bound to Proteins: Artificial Metalloenzymes P-Ligands Bound to Peptides MIXTURES OF MONODENTATE P-LIGANDS IN STEREO- AND REGIOSELECTIVE TRANSITION METAL CATALYSIS The General Concept of Using Mixtures of Monodentate Ligands Controlling Enantioselectivity by Using Mixtures of Monodentate P-Ligands CHIRAL TRIVALENT PHOSPHOROUS LIGANDS CATALYSTS Kinetic Resolution with Phosphine Organocatalysts Desymmetrization Asymmetric Catalytic Reactions of Prochiral Compounds with Phosphine Organocatalysts GENERAL METHODS FOR THE SYNTHESIS OF CHIRAL TPC Synthesis of P-Stereogenic Phosphines Via Enantioselective Alkylation Synthesis of P-Stereogenic Phosphorous Compounds Based on Chiral Aminoalcohols as Chiral Auxiliary Practical Routes to Chiral Phospholanes Chiral Ligands Made by Asymmetric Catalysis Phosphine Boranes and Related Trivalent P-Compounds as Intermediates in the Syntheses of Chiral Ligands and Organocatalysts Parallel Synthesis of Chiral P-Ligands CONTROLLING REGIO- AND STEREOCHEMISTRY IN METAL-CATALYZED AND METAL-MEDIATED REACTIONS WITH THE AID OF SUBSTRATE-BOUND REAGENT-DIRECTING PHOSPHINE GROUPS Design and Preparation of the Reagent-Directing o-DPPB Group Application in Directed Hydroformylation o-DPPB-Directed Atropdiastereoselective Biarylcoupling o-DPPB-Directed Palladium-Catalyzed Allylic Substitution o-DPPB- and o-DPPB-Directed Allylic Substitution with Organocopper Reagents CHARACTERIZATION OF P-LIGANDS METAL COMPLEXES NMR Spectroscopic Methods Properties of Phosphorous Ligands INDUSTRIAL ASPECTS The Role of Chiral Phosphines as Ligands The Difficult Task of Finding the Right Chiral Catalyst The Major Suppliers of Chiral Ligands and Related Services Commercially Available Chiral Ligands with Established Industrial Performance Technological Aspects Handling of IP Rights and Licensing for Production

About the Author :
Born 1954 Professor Börner finished his thesis in 1984. After several years of postdoctoral studies and industrial experience he moved to Rostock. Now, Professor Börner is head of department for asymmetric catalysis in Rostock and published over 140 scientific papers, reviews, book chapters and patents. He was awarded the departmental price for organic chemistry of the AdW, The Otto-Röhm price and the Descartes price of the European Union.