Predictive Biomarkers in Oncology
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Book 1
Book 2
Book 3
Home > Medicine & Health Science textbooks > Medical specialties, branches of medicine > Pathology > Predictive Biomarkers in Oncology: Applications in Precision Medicine
Predictive Biomarkers in Oncology: Applications in Precision Medicine

Predictive Biomarkers in Oncology: Applications in Precision Medicine


     0     
5
4
3
2
1



Out of Stock


Notify me when this book is in stock
X
About the Book

  “Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner.   This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized.   Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

Table of Contents:
Introduction to Predictive Biomarkers: definitions and characteristics.- Introduction to clinical trials, clinical trial designs and statistical terminology used for predictive biomarker research and validation.- Overview of Methods Used in Predictive Biomarker Studies in a Molecular Anatomic Pathology Laboratory.- Significance of Immunohistochemistry and In Situ Hybridization Techniques for Predictive Biomarker Studies.- Overview of PCR-based Technologies and Multiplexed Gene Analysis for Biomarker Studies.- Introduction to Microarray Technology.- Digital and Computational Pathology for Biomarker Discovery.- Detection of Predictive Biomarkers Using Liquid Biopsies.- Measurement of Predictive Cancer Biomarkers by Flow Cytometry.- Personalized Cancer Treatment and Patient Stratification Using Massive Parallel Sequencing (MPS) and Other OMICs Data.- Bioinformatic Methods and Resources for Biomarker Discovery, Validation, Development, and Integration.- Overview of Cell Signaling Pathwaysin Cancer.- Steroid Hormone and Nuclear Receptor signaling pathways.- Protein kinase C Signaling in Carcinogenesis.- Roles of Rho/ROCK in Cancer Signaling.- Mitogen Activated Protein Kinase (MAPK) Signaling.- Notch Signaling Pathway in Carcinogenesis.- Signaling of the ErbB receptor Family in Carcinogenesis and the Development of Targeted Therapies.- Signaling Pathways in Tumor Angiogenesis and Anti-angiogenic Therapies in Human Cancer.- Role of PI3K/AKT/mTOR in Cancer Signaling.- Met Signaling in Carcinogenesis.- Role of Insulin-like Growth Factor Receptors in Cancer Signaling.- Role of Wnt/β-catenin Pathway in Cancer Signaling.- Hedgehog Signaling in Carcinogenesis.- TGF-β and the SMAD Signaling Pathway in Carcinogenesis.- Role of JAK-STAT Pathway in Cancer Signaling.- NF-kB signaling pathways in Carcinogenesis.- Immune-Signaling in Carcinogenesis.- Predictive Biomarkers and Targeted Therapies in Immuno-Oncology.- Role of Protein Tyrosine Phosphatases in Cancer Signaling.- Predictiveand Prognostic Biomarkers in Myeloid Neoplasms.- Predictive Biomarkers and Targeted Therapies for Lymphoid Malignancies.- Targeted Therapies for Pediatric Central Nervous System Tumors.- Predictive Biomarkers and Targeted Therapies in Adult Brain Cancers.- Predictive Biomarkers and Targeted Therapies in Breast Cancer.- Predictive Biomarkers in Lung Cancer.- Predictive Biomarkers and Targeted Therapies in Genitourinary Cancers.- Predictive Biomarkers and Targeted Therapies in Colorectal Cancer.- Predictive Markers and Targeted Therapies in Gastroesophageal Cancer (GEC).- Predictive Biomarkers and Targeted Therapies in Hepatic, Pancreatic, and Biliary Cancers .- Gynecological Cancers & Head and Neck Cancers.- Predictive Biomarkers and Targeted Therapies in Head and Neck Cancer.- Predictive Biomarkers and Targeted Therapies in the Skin.- Predictive Biomarkers and Targeted Therapies in Sarcomas.- Predictive Markers and Targeted Therapies in Thyroid Cancer and Selected Endocrine Tumors.- The Response Evaluation Criteria in Solid Tumors (RECIST).- IVDs and FDA Marketing Authorizations: A General Overview of FDA Approval Process of an IVD Companion Diagnostic Device in Oncology.- Quality Control of Immunohistochemical and In Situ hybridization Predictive Biomarkers for Patient Treatment: Experience from International Guidelines and International Quality Control Schemes.- Use of Companion Diagnostics (CDx) and Predictive Biomarkers for Cancer Targeted Therapy. Clinical Applications in Precision Medicine.- Policy issues in the clinical development and use of predictive biomarkers for molecular targeted therapies.- Role of central laboratories in research, validation and application of predictive biomarkers.- Prominent Precision Medicine Clinical Trials in Oncology Around the World.- Precision Medicine Clinical Trials: Successes and Disappointments, Challenges and Opportunities. Lessons Learnt.- FDA Approved Targeted Therapies in Oncology.

About the Author :
Sunil Badve Indiana University School of Medicine Indianapolis, IN USA George Kumar Targos Inc. Issaquah, WA USA


Best Sellers


Product Details
  • ISBN-13: 9783319952277
  • Publisher: Springer International Publishing AG
  • Publisher Imprint: Springer International Publishing AG
  • Height: 254 mm
  • No of Pages: 642
  • Sub Title: Applications in Precision Medicine
  • ISBN-10: 3319952277
  • Publisher Date: 20 Dec 2018
  • Binding: Hardback
  • Language: English
  • Returnable: Y
  • Width: 178 mm


Similar Products

Add Photo
Add Photo

Customer Reviews

REVIEWS      0     
Click Here To Be The First to Review this Product
Predictive Biomarkers in Oncology: Applications in Precision Medicine
Springer International Publishing AG -
Predictive Biomarkers in Oncology: Applications in Precision Medicine
Writing guidlines
We want to publish your review, so please:
  • keep your review on the product. Review's that defame author's character will be rejected.
  • Keep your review focused on the product.
  • Avoid writing about customer service. contact us instead if you have issue requiring immediate attention.
  • Refrain from mentioning competitors or the specific price you paid for the product.
  • Do not include any personally identifiable information, such as full names.

Predictive Biomarkers in Oncology: Applications in Precision Medicine

Required fields are marked with *

Review Title*
Review
    Add Photo Add up to 6 photos
    Would you recommend this product to a friend?
    Tag this Book Read more
    Does your review contain spoilers?
    What type of reader best describes you?
    I agree to the terms & conditions
    You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.

    CUSTOMER RATINGS AND REVIEWS AND QUESTIONS AND ANSWERS TERMS OF USE

    These Terms of Use govern your conduct associated with the Customer Ratings and Reviews and/or Questions and Answers service offered by Bookswagon (the "CRR Service").


    By submitting any content to Bookswagon, you guarantee that:
    • You are the sole author and owner of the intellectual property rights in the content;
    • All "moral rights" that you may have in such content have been voluntarily waived by you;
    • All content that you post is accurate;
    • You are at least 13 years old;
    • Use of the content you supply does not violate these Terms of Use and will not cause injury to any person or entity.
    You further agree that you may not submit any content:
    • That is known by you to be false, inaccurate or misleading;
    • That infringes any third party's copyright, patent, trademark, trade secret or other proprietary rights or rights of publicity or privacy;
    • That violates any law, statute, ordinance or regulation (including, but not limited to, those governing, consumer protection, unfair competition, anti-discrimination or false advertising);
    • That is, or may reasonably be considered to be, defamatory, libelous, hateful, racially or religiously biased or offensive, unlawfully threatening or unlawfully harassing to any individual, partnership or corporation;
    • For which you were compensated or granted any consideration by any unapproved third party;
    • That includes any information that references other websites, addresses, email addresses, contact information or phone numbers;
    • That contains any computer viruses, worms or other potentially damaging computer programs or files.
    You agree to indemnify and hold Bookswagon (and its officers, directors, agents, subsidiaries, joint ventures, employees and third-party service providers, including but not limited to Bazaarvoice, Inc.), harmless from all claims, demands, and damages (actual and consequential) of every kind and nature, known and unknown including reasonable attorneys' fees, arising out of a breach of your representations and warranties set forth above, or your violation of any law or the rights of a third party.


    For any content that you submit, you grant Bookswagon a perpetual, irrevocable, royalty-free, transferable right and license to use, copy, modify, delete in its entirety, adapt, publish, translate, create derivative works from and/or sell, transfer, and/or distribute such content and/or incorporate such content into any form, medium or technology throughout the world without compensation to you. Additionally,  Bookswagon may transfer or share any personal information that you submit with its third-party service providers, including but not limited to Bazaarvoice, Inc. in accordance with  Privacy Policy


    All content that you submit may be used at Bookswagon's sole discretion. Bookswagon reserves the right to change, condense, withhold publication, remove or delete any content on Bookswagon's website that Bookswagon deems, in its sole discretion, to violate the content guidelines or any other provision of these Terms of Use.  Bookswagon does not guarantee that you will have any recourse through Bookswagon to edit or delete any content you have submitted. Ratings and written comments are generally posted within two to four business days. However, Bookswagon reserves the right to remove or to refuse to post any submission to the extent authorized by law. You acknowledge that you, not Bookswagon, are responsible for the contents of your submission. None of the content that you submit shall be subject to any obligation of confidence on the part of Bookswagon, its agents, subsidiaries, affiliates, partners or third party service providers (including but not limited to Bazaarvoice, Inc.)and their respective directors, officers and employees.

    Accept

    Fresh on the Shelf


    Inspired by your browsing history


    Your review has been submitted!

    You've already reviewed this product!