Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects.
This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.
Table of Contents:
- Overview: The Pathobiology of Head and Neck Cancer. - Targeting the ErbB Family in Head and Neck Cancer. - c-MET in Head and Neck Squamous Cell Carcinoma. - Transforming Growth Factor Beta (TGF-β) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC). - The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma. - Jak/STAT Signaling in Head and Neck Cancer. - Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC). - Role of the NOTCH Signaling Pathway in Head and Neck Cancer. - P53 in Head and Neck Squamous Cell Carcinoma. - APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck. - The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma. - Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer. - Inflammation and Head and Neck Squamous Cell Carcinoma. - Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC). - The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma. - Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer. - FAK as a Target for Therapy in Head and Neck Cancer. - Diversity of Wnt/β-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment. - Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer. - Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer. - Treatment Paradigms in HPV-Associated SCCHN.
About the Author :
Barbara Burtness, M.D. is Professor of Medicine, Yale University School of Medicine and Co-Leader, Developmental Therapeutics Program, Yale Cancer Center. As Chair of the Head and Neck Committee in Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer.
Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer and Co-leader of the Program in Molecular Therapeutics at the Fox Chase Cancer Center. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes to effect disease control and cure.
Review :
"The book is intended primarily for clinicians, fellows, interns, and trainees, but medical students who may be interested in head and neck cancer but face the challenge of updating themselves on the latest innovations may also find this book very useful. ... this is an informative and authoritative book on the subject that includes experiences from clinicians and scientists working on head and neck cancer at some of the most renowned cancer centers in the world." (Ravi Salgia, Doody's Book Reviews, March, 2019)
