Experimental design is a central task in inverse problems that concerns the planning of data collection in accordance with a specific reconstruction goal. In general, not all data are equally informative. Choices made when setting up an experiment - such as how measurements are taken or how the physical test system is designed - alongside other factors, determine whether the resulting data contain useful information for the inference problem. In practice, where only a limited amount of data can be collected, it is therefore crucial to focus on highly informative experiments in order to enable reconstruction and improve its quality. With this in mind, we hope to encourage an interdisciplinary perspective on inverse problems, in which planning, experimentation, and inference are carried out in collaboration between practitioners and mathematicians.
Traditionally, experimental design has been formulated as an optimization problem: identifying the “best” experiments according to a chosen mathematical criterion. This approach is often ambitious, and the associated computational costs can be substantial. In this book, we advocate for a broader notion of experimental design that incorporates additional nuances. In particular, we adopt a qualitative perspective: rather than searching for optimal experiments, the goal is to identify experiments that enable reliable reconstruction. This viewpoint has gained increasing attention in recent years, and we review two methods that are rooted in identifiability analysis and sensitivity analysis: a theory-based approach and a sampling-based approach. Both shall be illustrated on an example from mathematical biology: chemotaxis, the directed movement of bacteria in response to chemical signals, along with the associated inverse problem of reconstructing motion parameters.
Table of Contents:
Introduction.- Inverse Problems.- Identifiability analysis.- Experimental Design.- The Inverse Problem for Chemotaxis. Structural Identifiability.- Theory-based Experimental Design.- Numerical experiments.- Experimental Design through Sampling.- Discussion, Appendix.
About the Author :
Kathrin Hellmuth holds a PhD in Mathematics from the Julius-Maximilians-Universität Würzburg, Germany, where this book originated as her dissertation thesis. During her PhD she collaborated closely with Christian Klingenberg, Qin Li and Min Tang.
She is currently a PostDoc in Mathematics at the California Institute of Technology, CA, USA where she continues to explore the interface between inverse problems and differential equation in parameter identification and interacting particle samplers.
