This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction.
In this new edition, new aspects in the vascular system are covered, including biomechanics of cardiovascular calcification, biomechanics and mechanobiology of the right ventricular circulation, mechanotransduction in brachial arteries, effects of substrate topography on vascular endothelial structure and function and effects of red blood cell mechanical behaviors on the blood flow. For the endothelial glycocalyx, in addition to updating the chemical components of the glycocalyx, the role of specific glycocalyx components, glycosaminoglycans, are summarized for their roles in capillary walls. Another new chapter introduces how the pathological pattern description in ancient medical records is correlated to the modern cytokine effect on the vascular system. Other new chapters introduce the lab-on-chips applications for cardiovascular research, the therapeutic and diagnostic nanomedicine for cardiovascular diseases and non-invasive techniques for cardiovascular diagnosis.
This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.
Table of Contents:
The role of glycocalyx in vascular angiogenesis and function Ye Zeng et al.- The Molecular structure of the endothelial glycocalyx layer and surface layer modulation of transvascular exchange Fitz Roy Curry.- Glycosaminoglycans and their role in capillary walls.- Mechanobiology and Vascular Remodeling From Membrane to Nucleus Ying Xin Qi et al.- Abdominal Aortic Aneurysm Pathomechanics Current Understanding and Future Direction Robert Peattie and Sudharsan Madhavan.- Biomechanics of Cardiovascular CalcificationLuis Cardoso et al.- Biomechanics and Mechanobiology of the Right ventricular CirculationEdward Manning and Abhay Ramachandra.- The examination of mechanotransduction through brachial arteries via flow medicated dilation Qianhong Wu.- Temporal Progression of IL-1 Activation in the Vascular System A Six Day Pathological Pattern Described in Ancient Medical TextsYang Liu.- Effects of the Mechanical Behaviors of Red Blood Cells on the Blood.- Modeling of Tumor Cell Adhesion Extravasation and Sorting in Microvascular System.- Effect of substrate topography on vascular endothelial structure and function.- Therapeutic and diagnostic translational nanomedicine for cardiovascular diseasesRyan Williams.- Hypothermia used in medical applications for brain and spinal cord injury patients Liang Zhu.- Tumor metastasis in the microcirculation.- Transport across the blood brain barrierBingmei Fu.- Lab on chips for cardiovascular research.- 3D Computational Modeling of Blast Wave Transmission from External Ear to Cochlear Hair.- Mathematical Models of Cell Response following heating.- New non invasive techniques for cardiovascular diagnosis.
About the Author :
Bingmei M Fu is a Herbert G. Kayser Professor of Biomedical Engineering at The City College of the City University of New York. She received her BS and MS in Modern Mechanics from the University of Science and Technology of China, her Ph.D. in Mechanical Engineering from the City University of New York and her postdoctoral training in School of Medicine at the University of California, Davis. Prior to her appointment at City College, she was an Associate Professor in Mechanical Engineering at the University of Nevada, Las Vegas. She is a fellow of the American Institute for Medical and Biological Engineering and the Biomedical Engineering Society and a member of the American Association for the Advancement of Science. Her major research activities involve modelling nano and micro transport phenomena in the microcirculation, and corresponding in vivo animal and in vitro culture cell experiments.
Neil T. Wright is an Associate Professor of Mechanical Engineering at Michigan State University. He received his BS in Engineering Science and Mechanics from Virginia Tech, his MS in Mechanical Engineering from the University of Colorado, and his PhD in Mechanical Engineering and Applied Mechanics from the University of Pennsylvania. Prior to his appointment at Michigan State, he was an Associate Professor at the University of Maryland, Baltimore County. He is a fellow of the American Society of Mechanical Engineers and a member of the American Association for the Advancement of Science. His laboratory measures the thermophysical properties of biological materials and superconducting niobium.
