Instant Notes in Bioinformatics
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Home > Mathematics and Science Textbooks > Biology, life sciences > Life sciences: general issues > Genetics (non-medical) > Instant Notes in Bioinformatics: (Instant Notes)
Instant Notes in Bioinformatics: (Instant Notes)

Instant Notes in Bioinformatics: (Instant Notes)


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About the Book

Instant Notes in Bioinformatics describes what is possible, and the strengths, limitations and potential pitfalls of methods and analyses. The book begins by describing data generation and databases. Following this it takes us to the newer bioinformatics problems associated with structures, expression, proteomics, interactions and pathways. The important areas in bioinformatics are covered to encourage easy learning and revision.

Table of Contents:
SECTION A - OVERVIEW OF BIOINFORMATICS. The scope of bioinformatics. Bioinformatics and the Internet. Useful bioinformatics sites on the WWW SECTION B - DATA ACQUISITION. Sequencing DNA, RNA and proteins. Determination of protein structure. Gene and protein expression data. Protein interaction data. SECTION C - DATABASES - CONTENTS STRUCTURE AND ANNOTATION. File formats. Annotated sequence databases. Genome and organism-specific databases. Miscellaneous databases. SECTION D - RETRIEVAL OF BIOLOGICAL DATA. Data retrieval with Entrez and DBGET/LinkDB. Data retrieval with SRS (sequence retrieval sequence). SECTION E - SEARCHING SEQUENCE DATABASES BY SEQUENCE SIMILARITY CRITERIA. Sequence similarity searches. Amino acid substitution matrices. Database searches: FASTA and BLAST. Sequence filters. Iterative database searches and PSI-BLAST. SECTION F - MULTIPLE SEQUENCE ALIGNMENT: GENE AND PROTEIN FAMILIES. Multiple sequence alignment and family relationships. Protein families and pattern databases. Protein domain families. SECTION G - PHYLOGENETICS. Phylogenetics, cladistics and ontology. Building phylogenetic trees. Evolution of macromolecular sequences. SECTION H - SEQUENCE ANNOTATION. Principles of genome annotation. Annotation tools and resources. SECTION I - STRUCTURAL BIOINFORMATICS. Conceptual models of protein structure. The relationship of protein three-dimensional structure to protein function. The evolution of protein structure and function. Obtaining, viewing and analyzing structural data. Structural alignment. Classification of proteins of known three-dimensional structure: CATH and SCOP. Introduction to protein structure prediction. Structure prediction by comparative modeling. Secondary structure prediction. Advanced protein structure prediction and prediction strategies. SECTION J - MICROARRAY DATA ANALYSIS. Microarray data: analysis method. Microarray data: tools and resources. Sequence sampling and SAGE. SECTION K - PROTEOMIC DATA ANALYSIS. Analyzing data from 2-DE gels. Analyzing protein mass spectrometry data. SECTION L - HIGHER-ORDER SYSTEMS. Modeling and reconstructing molecular pathways. Protein interaction informatics. Higher-order models. SECTION M - CHEMINFORMATICS IN BIOLOGY. Conventions for representing molecules. Cheminformatics resources. SECTION N - BIOINFORMATICS IN THE PHARMACEUTICAL INDUSTRY. Bioinformatics and drug discovery. Pharmainformatics resources. SECTION O - BASIC PRINCIPLES OF COMPUTING IN BIOINFORMATICS. Running computer software. Computer operating systems. Software downloading and installation. Database management

About the Author :
Dr David Westheand and Dr Howard Parish, School of Biochemistry and Microbiology, University of Leeds


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Product Details
  • ISBN-13: 9781859962725
  • Publisher: Bios Scientific Publishers Ltd
  • Publisher Imprint: Bios Scientific Publishers Ltd
  • Language: English
  • No of Pages: 268
  • Series Title: Instant Notes
  • ISBN-10: 1859962726
  • Publisher Date: 15 Jun 2002
  • Binding: Paperback
  • No of Pages: 268
  • Returnable: N
  • Weight: 494 gr


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