Raynaud's Phenomenon and Peripheral Ischemic Syndromes
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Raynaud's Phenomenon and Peripheral Ischemic Syndromes: (Uni-Med Science)

Raynaud's Phenomenon and Peripheral Ischemic Syndromes: (Uni-Med Science)


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Table of Contents:
Contents1. Anatomy, Physiology and Pathophysiology of Raynaud's Phenomenon and Peripheral Ischemic Syndromes 181.1. Definition and classification of Raynaud's Phenomenon 181.1.1. Primary and secondary Raynaud's Phenomenon 181.2. Normal vascular anatomy 191.3. General physiology of palmar perfusion and pathophysiology of Raynaud's phenomenon 201.3.1. Rheological factors 201.3.2. Alterations in vasomotor homeostasis 211.3.3. Endothelium-dependent vasoregulation 211.3.4. Endothelium-independent vasoregulation 211.3.5. Microcirculatory flow and blood cell activation 211.3.6. Non-vascular factors 221.3.7. Autoantibodies 221.4. Special pathophysiological mechanisms in peripheral ischemia syndromes 231.4.1. Compression of arteries and veins in the scalenus gap 231.4.2. Compression of the carpal canal (Carpal Tunnel Syndrome, Tardy Median Palsy) 231.4.3. Sudeck's atrophy as an example of posttraumatic disorder 241.4.4. Thromboangiitis obliterans (Buerger's Disease) 241.4.5. Vibration disease 251.5. Summary 271.6. References 272. Definition, Classification and Diagnosis of Primary and Secondary Raynaud's Phenomenon 322.1. Definition 322.2. Frequency 322.3. Classification 342.4. Differential diagnoses for primary and secondary Raynaud's phenomenon 342.5. Diagnosis 362.6. Capillaroscopy 362.7. Summary 392.8. References 393. Differential Diagnoses of Raynaud's Phenomenon and Peripheral Ischemic Syndromes 443.1. Introduction 443.2. Clinical association and differential diagnoses of secondary Raynaud's phenomenon 453.2.1. Connective tissue diseases 453.2.2. Vasculitis 463.2.2.1. Primary systemic vasculitis 463.2.2.2. Secondary vasculitides 463.2.3. Differential diagnose of finger-tip necrosis and Raynaud's phenomenon versus vasculitis 483.2.4. Blue toe syndrome 503.2.4.1. Antiphospholipid syndrome (APS) 503.2.4.2. Arterial occlusive disease 513.3. Summary 523.4. References 524. Differential Diagnoses of Dermatological Peripheral Cutaneous Circulatory Disorders 544.1. Functional angiopathies 544.1.1. Raynaud's phenomenon 544.1.2. Acrocyanosis 554.1.3. Erythromelalgia 564.1.4. Livedo reticularis 574.2. Microcirculatory alterations due to inflammatory and/or thrombotic angiopathies 584.2.1. Livedoid vasculopathy 594.2.2. Cutaneous polyarteritis nodosa 604.2.3. Leucocytoclastic vasculitis 604.2.4. Polycythemia vera 614.2.5. Emboli 624.2.5.1. Septic emboli and vasculitis with coagulopathy in bacteriemia, sepsis and fulminant purpura 624.2.5.2. Cholesterol emboli 624.2.6. Cryopathies 624.2.6.1. Cryoglobulinemia 624.2.6.2. Cold agglutinin disease 634.2.6.3. Cryofibrinogenemia 644.3. Dermatological differential diagnoses imitating cutaneous circulation disorders 644.3.1. Chilblain lupus erythematosus 644.3.2. Pernio (Chilblains) 644.3.3. Peripheral pernio/acral livedo in myeloproliferative diseases 654.3.4. Chemotherapy-induced peripheral erythemas 654.3.5. Sudeck's disease 664.3.6. Paroxysmal finger hematoma 664.3.7. Kaposi's sarcoma 664.3.8. Lupus pernio 674.3.9. Acrodermatitis chronica atrophicans 674.4. References 685. Is There a Raynaud's Phenomenon of Internal Organs? 745.1. Introduction 745.2. Heart 755.3. Lung 755.4. Kidneys 765.4.1. Types of vasospastic renal failure 765.4.2. Functional renal failure in systemic sclerosis 765.5. Gastrointestinal system 775.6. Liver 775.7. Haematopoietic system 785.8. Central nervous system 785.8.1. Migraine 785.8.2. Reversible cerebral vasoconstrictive syndromes 785.9. Ocular diseases 795.10. Pregnancy and puerperium 795.11. Summary 795.12. References 796. Conventional Therapeutic Concepts of Raynaud's Phenomenon 846.1. Introduction 846.2. Supportive care 846.3. Non drug-based therapies 856.4. Drug therapies 856.4.1. Topical therapies 856.4.2. Systemic drug therapies 856.4.2.1. Calcium antagonists 856.4.2.2. Prostaglandins, iloprost 866.4.2.3. Other prostaglandin analogues 886.4.2.4. Angiotensin-II-receptor-1 (AT-1) antagonists and ACE-inhibitors 886.4.2.5. Serotonin re-uptake inhibitors 896.4.2.6. Other vasodilators 896.4.2.7. Drugs with effect on the rheologic properties of the blood 906.5. Surgical therapies 906.6. Summary 916.7. Literature 917. New Strategies for Treating Peripheral Ischemia 967.1. Introduction 967.2. New therapeutic concepts 967.2.1. Inhibition of endothelin 967.2.1.1. The endothelin system 967.2.1.2. Inhibition of the endothelin receptor as a therapeutic strategy 977.2.1.3. Therapeutic endothelin receptor inhibition in peripheral ischemia 997.2.1.3.1. Case reports and retrospective case studies 1017.2.1.3.2. Randomized clinical trials: RAPIDS-1 and RAPIDS-2 1017.2.1.4. Summary of therapeutic endothelin receptor inhibition 1047.2.2. Inhibition of phosphodiesterases 1047.2.2.1. The role of phosphodiesterases in the regulation of vascular tone 1047.2.2.2. Inhibition of PDE-5 as a therapeutic strategy 1057.2.2.3. Therapeutic inhibition of PDE-5 in peripheral ischemia 1057.2.2.3.1. Case reports and retrospective case studies 1057.2.2.3.2. Clinical trials 1087.2.2.4. Summary of therapeutic PDE-5 inhibition 1097.3. Conclusion 1107.4. References 1118. Glossary 116 Index 118


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Product Details
  • ISBN-13: 9781848150003
  • Publisher: Uni-Med Verlag Ag
  • Publisher Imprint: UNI-MED Verlag AG
  • Height: 240 mm
  • Width: 170 mm
  • ISBN-10: 1848150008
  • Publisher Date: /09/2007
  • Binding: Hardback
  • Series Title: Uni-Med Science


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