Stress Response in Pathogenic Bacteria: (Advances in Molecular and Cellular Microbiology)

The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed.

Table of Contents:
Part 1: Oxidative and Nitrosative Stress 1: Oxidative and Nitrosative Stress Defence Systems in Escherichia coli and Pseudomonas aeruginosa 2: Coordinated Regulation of Stress and Virulence Adaptations in Stages of Haemophilus Pathogenesis 3: Nitric Oxide Stress in E. coli and Salmonella 4: Nitric Oxide and Gram-positive Pathogens Part 2: Novel Gene Regulation in Response to Host Defences 5: Novel Regulation in Response to Host-generated Stresses 6: Stress Responses in the Pathogenic Neisseria Part 3: Acid Stress: pH Control and Survival in the Human Host 7: Acid Survival Mechanisms of Bacterial Pathogens of the Digestive Tract 8: Urease and the Bacterial Acid Stress Response Part 4: Nutrient Stress 9: Secretion Systems and Metabolism in the Pathogenic Yersiniae 10: Response of Neisseria gonorrhoeae to Oxygen Limitation and Excess Part 5: Metal Ions and Pathogenic Bacteria 11: Copper and Zinc Stress in Bacteria 12: Metal Ion Sensing in Mycobacterium tuberculosis 13: Salmonella and the Host in the Battle for Iron

About the Author :
Dr Stephen Kidd was awarded his PhD in Molecular Microbiology from the University of Queensland. He then worked in Prof. Nigel Brown's research group (The University of Birmingham, UK) on the transcription factor MerR; the mechanism of its environmental stress response. He started work on a number of other MerR-like regulators and then after moving back to the University of Queensland, some of these which functioned in disulfide stress response in pathogenic bacteria. In November 2008 he started working at the University of Adelaide as a Group Leader in Microbiology and Immunology.

Review :
"...researchers with an interest in the molecular mechanisms that underpin the adaptations to the sometimes harsh environments encountered within the host will find this a very useful volume. Indeed, students embarking on research projects in this area will find this an invaluable starting point."--Conor O'Byrne, National University of Ireland (2/1/2012 12:00:00 AM)