Mechanical Stimulation of Skeletal Muscle Mitigates Glucocorticoid Induced Decreases in Prostaglandin Synthesis
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Mechanical Stimulation of Skeletal Muscle Mitigates Glucocorticoid Induced Decreases in Prostaglandin Synthesis

Mechanical Stimulation of Skeletal Muscle Mitigates Glucocorticoid Induced Decreases in Prostaglandin Synthesis


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About the Book

The glucocorticoid dexamethasone (Dex) induces a decline in protein synthesis and protein content of tissue cultured, avian skeletal muscle cells, and this atrophy is attenuated by repetitive mechanical stretch. Since the prostaglandin synthesis inhibitor indomethacin mitigated this stretch attenuation of muscle atrophy, the role of prostaglandins as growth modulators in these processes was examined. Dex at 10(exp -8) M reduced PGF(sub 2(alpha)) production 55 percent - 65 percent and PGE(sub 2) production 84 - 90 percent after 24 - 72 h of incubation in static cultures. Repetitive 10 percent stretch-relaxations of the non-Dex treated cultures increased PGF(sub 2(alpha)) efflux 41 percent at 24 h and 276 percent at 72 h and increased PGE(sub 2) production 51 percent at 24 h and 236 percent at 72 h. Mechanical stimulation of Dex treated cultures increased PGF(sub 2(alpha)) production 162 percent after 24 h, thus returning PGF(sub 2(alpha)) efflux to the level of non-Dex treated cultures. At 72 h, stretch increased PGF(sub 2(alpha)) efflux 65 percent in Dex treated cultures, but PGF(sub 2(alpha)) production was 45-84 percent less than non-Dex treated cultures. Mechanical stimulation of Dex treated cultures increased PGE(sub 2) production at 24 h, but not at 72 h. Dex reduced prostaglandin H synthase (PGHS) activity in the muscle cultures by 70 percent after 8 - 24 h of incubation, and mechanical stimulation increased PGHS activity of the Dex treated cultures by 98 percent. It is concluded that repetitive mechanical stimulation attenuates the catabolic effects of Dex on cultured skeletal muscle cells in part by reversing the Dex-induced declines in PGHS activity and prostaglandin production. Chromiak, Joseph A. and Vandenburgh, Herman H. Unspecified Center NAG2-414...


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Product Details
  • ISBN-13: 9781722365097
  • Publisher: Createspace Independent Publishing Platform
  • Publisher Imprint: Createspace Independent Publishing Platform
  • Height: 279 mm
  • No of Pages: 36
  • Spine Width: 2 mm
  • Width: 216 mm
  • ISBN-10: 1722365099
  • Publisher Date: 07 Jul 2018
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 109 gr


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