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Home > Reference > Research and information: general > Research methods: general > Modeling Grade IV Gas Emboli Using a Limited Failure Population Model with Random Effects
Modeling Grade IV Gas Emboli Using a Limited Failure Population Model with Random Effects

Modeling Grade IV Gas Emboli Using a Limited Failure Population Model with Random Effects


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About the Book

Venous gas emboli (VGE) (gas bubbles in venous blood) are associated with an increased risk of decompression sickness (DCS) in hypobaric environments. A high grade of VGE can be a precursor to serious DCS. In this paper, we model time to Grade IV VGE considering a subset of individuals assumed to be immune from experiencing VGE. Our data contain monitoring test results from subjects undergoing up to 13 denitrogenation test procedures prior to exposure to a hypobaric environment. The onset time of Grade IV VGE is recorded as contained within certain time intervals. We fit a parametric (lognormal) mixture survival model to the interval-and right-censored data to account for the possibility of a subset of "cured" individuals who are immune to the event. Our model contains random subject effects to account for correlations between repeated measurements on a single individual. Model assessments and cross-validation indicate that this limited failure population mixture model is an improvement over a model that does not account for the potential of a fraction of cured individuals. We also evaluated some alternative mixture models. Predictions from the best fitted mixture model indicate that the actual process is reasonably approximated by a limited failure population model.Thompson, Laura A. and Conkin, Johnny and Chhikara, Raj S. and Powell, Michael R.Johnson Space CenterAEROEMBOLISM; DECOMPRESSION SICKNESS; GOODNESS OF FIT; RANDOM PROCESSES; PARAMETER IDENTIFICATION; MATHEMATICAL MODELS; CENSORED DATA (MATHEMATICS); DENITROGENATION; EXTRAVEHICULAR ACTIVITY; DATA CORRELATION


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Product Details
  • ISBN-13: 9781720628347
  • Publisher: Createspace Independent Publishing Platform
  • Publisher Imprint: Createspace Independent Publishing Platform
  • Height: 279 mm
  • No of Pages: 48
  • Spine Width: 3 mm
  • Width: 216 mm
  • ISBN-10: 1720628343
  • Publisher Date: 03 Jun 2018
  • Binding: Paperback
  • Language: English
  • Returnable: N
  • Weight: 136 gr


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