CRISPR
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CRISPR: Biology and Applications(ASM Books)

CRISPR: Biology and Applications(ASM Books)


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About the Book

Table of Contents:
Contributors vii Preface xi Section I Diversity of CRISPR‐Cas Systems 1 1 CRISPR-Cas Systems: Core Features and Common Mechanisms 3 Rodolphe Barrangou, Luciano A. Marraffini, and Erik J. Sontheimer 2 Evolutionary Classification of CRISPR-Cas Systems 13 Kira S. Makarova, Yuri I. Wolf, and Eugene V. Koonin 3 Molecular Mechanisms of Type I CRISPR-Cas Systems 39 John van der Oost 4 Molecular Mechanisms of Type II CRISPR‐Cas Systems 53 Tautvydas Karvelis and Virginijus Siksnys 5 Mechanism of Type III CRISPR‐Cas Immunity 71 Luciano A. Marraffini 6 Type V CRISPR‐Cas Systems 85 Morgan Quinn Beckett, Anita Ramachandran, and Scott Bailey 7 CRISPR-Cas13: Biology, Mechanism, and Applications of RNA-Guided, RNA-Targeting CRISPR Systems 99 Omar O. Abudayyeh and Jonathan S. Gootenberg Section II CRISPR‐Cas Biology 121 8 CRISPR-Cas, Horizontal Gene Transfer, and the Flexible (Pan) Genome 123 Uri Gophna 9 Evasion Tactics Manifested by Bacteriophages against Bacterial Immunity 131 Jenny Y. Zhang, Sutharsan Govindarajan, and Joseph Bondy-Denomy 10 Regulation of CRISPR‐Cas Expression and Function 145 Leah M. Smith, Aroa Rey Campa, and Peter C. Fineran Section III CRISPR‐Based Technologies and Applications 163 11 Genome Editing with CRISPR‐Cas Systems 165 Peter Lotfy and Patrick D. Hsu 12 Genetic and Epigenetic Modulation of Gene Expression by CRISPR-dCas Systems 195 Jasprina N. Noordermeer, Crystal Chen, and Lei S. Qi 13 CRISPR Screens 213 Jonathan D. D’Gama, Joseph S. Park, and Matthew K. Waldor 14 CRISPR‐Based Antimicrobials 233 Justen Russell and David Bikard 15 Exploiting CRISPR‐Cas Systems To Provide Phage Resistance in Industrial Bacteria 249 Rodolphe Barrangou and Avery Roberts 16 Recording Biological Information with CRISPR‐Cas Systems 267 Mariia Y. Cherepkova, Tanmay Tanna, and Randall J. Platt Afterword 281 Index 283

About the Author :
ABOUT THE EDITORS Rodolphe Barrangou is the Todd R. Klaenhammer Distinguished Professor in the Department of Food, Bioprocessing and Nutrition Sciences at North Carolina State University; a member of the AAM, NAS, NAE, and NAI; a cofounder of Intellia Therapeutics, Locus Biosciences, Ancilia Biosciences, CRISPR Biotechnologies, and TreeCo; and Editor- in-Chief of The CRISPR Journal. Erik J. Sontheimer is the Pillar Chair in Biomedical Research and Professor in the RNA Therapeutics Institute at the University of Massachusetts Chan Medical School; an Associate Editor of RNA; a member of the AAM; a cofounder of Intellia Therapeutics; and a Scientific Advisory Board member at Tessera Therapeutics. Luciano A. Marraffini is the Kayden Family Professor and Head of the Laboratory of Bacteriology at The Rockefeller University; a Howard Hughes Medical Institute Investigator; a member of the AAM, AAAS, and NAS; and a cofounder of Intellia Therapeutics, CRISPR Biotechnologies, and Eligo Biosciences.


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Product Details
  • ISBN-13: 9781683670377
  • Publisher: American Society for Microbiology
  • Publisher Imprint: American Society for Microbiology
  • Height: 277 mm
  • No of Pages: 304
  • Returnable: N
  • Spine Width: 25 mm
  • Weight: 1066 gr
  • ISBN-10: 168367037X
  • Publisher Date: 25 Aug 2022
  • Binding: Hardback
  • Language: English
  • Returnable: N
  • Series Title: ASM Books
  • Sub Title: Biology and Applications
  • Width: 221 mm


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