Adoptive Immunotherapy
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Home > Medicine & Health Science textbooks > Clinical and internal medicine > Diseases and disorders > Chemotherapy > Adoptive Immunotherapy: Methods and Protocols(No. 109 Methods in Molecular Biology)
Adoptive Immunotherapy: Methods and Protocols(No. 109 Methods in Molecular Biology)

Adoptive Immunotherapy: Methods and Protocols(No. 109 Methods in Molecular Biology)


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About the Book

Experts from various fields contributed to this comprehensive collection of state-of-the-art methods for adoptive immunotherapy. Adoptive transfer of tailored antigen-specific immune cells and/or optimally designed immunological effector molecules is an elegant and promising approach to establish or restore protective immune responses. Recent technical advances and specific methods from the areas of dendritic cell therapy, generation of antigen-specific cytotoxic T cells, and anti-tumor treatment with specific antibodies have been compiled, with a an emphasis on preclinical and clinical applications.

Table of Contents:
Contents; 1 Exploiting Dentritic Cells for Active Immunotherapy of Cancer and Chronic Infection; David O'Neill and Nina Bhardwaj; 2 A Mathematical Approach for Optimizing Dentritic Cell-Based Immunotherapy; Gennady Bocharov, Neville J. Ford, and Burkhard Ludewig; 3 Delivery of Tumor Antigens to Dentritic Cells using Biodegradable Microspheres; Ying Waeckerle-Men, Bruno Gander, and Marcus Groettrup; 4 RNA Transfection of Dentritic Cells; Frank Grunebach, Martin R. Muller, and Peter Brossart; 5 Isolation and Generation of Clinical Grade Dendritic Cells Using the CliniMACS System; John D. M. Campbell, Christoph Piechaczek, Gregor Winkels, Edith Schwamborn, Daniela Micheli, Sonja Hennemann, and Jurgen; Schmitz; 6 Generation of Clinical Grade Monocyte-Derived Dendritic Cells using the CliniMACS System; Thomas Putz, Hubert Gander, Reinhold Ramoner, Claudia Zelle-Rieser, Andrea Rahm, Walter Nussbaumer, Georg Bartsch, Lorenz; Holtl, and Martin Thurnher; 7 Adenoviral Transduction of Dendritic Cells; Rienk Offringa, Kitty Kwappenberg, Martijn Rabelink, Delphine Rea, and Rob Hoeben; 8 Generation of Autologous Peptide- and Protein-Pulsed Dendritic Cells for Patient-Specific Immunotherapy; David O'Neill and Nina Bhardwaj; 9 Phenotypical and Functional Characterization of Clinical Grade Dendritic Cells; Jolanda M. de Vries, Gosse J. Adema, Cornelis J. A. Punt, and Carl G. Figdor; 10 Dendritic Cells in Clinical Trials for Multiple Myeloma; Volker L. Reichardt and Peter Brossart; 11 Identification of Tumor-Associated Autoantigens with SEREX; Ozlem Tureci, Dirk Usener, Sandra Schneider, and Ugur Sahin; 12 Application of Proteomics and Protein Analysis for Biomarker and Target Finding for Immunotherapy; Petra Weingarten, Petra Lutter, Andreas Wattenberg, Martin Blueggel, Sonja Bailey, Joachim Klose, Helmut E. Meyer, and Christoph; Huels; 13 Isolation and Expansion of Tumor-Reactive Cytotoxic T-Cell Clones for Adoptive Immunotherapy Helga Bernhard, Burkhard Schmidt, Dirk H. Busch, and Christian Peschel; 14 Tracking Adoptively Transferred Antigen-Specific T Cells with Peptide-MHC Multimers; Norbert Meidenbauer and Andreas Mackensen; 15 Gene Transfer of MHC-Restricted Receptors; Helmut W. H. G. Kessels, Monika C. Wolkers, and Ton N. M. Schumacher; 16 Immunotherapy with CTL Restricted by Nonself MHC; Liquan Gao, Anne-Marie Downs and Hans J. Stauss; 17 Designing TCRs for Cancer Immunotherapy; Ralf-Holger Voss, Jurgen Kuball, Matthias Theobald; 18 Isolation and Expansion of Tumor-Specific CD4+ T Cells by Means of Cytokine Secretion; Christian Becker; 19 Methods for the Ex Vivo Characterization of Human CD8+ T Subsets Based on Gene Expression and Replicative History Analysis; Nathalie Rufer, Patrick Reichenbach, and Pedro Romero; 20 Regulatory T Cells in Antitumor Therapy: Isolation and Functional of CD4+CD25+ Regulatory T cells; Helmut Jonuleit and Edgar Schmitt; 21 Monoclonal Antibody-Based Strategies in Autoimmunity and Transplantation; Lucienne Chatenoud; 22 Producing Bispecific and Bifunctional Antibodies; Dipankar Das and Mavanur R. Suresh; 23 Antibody-Cytokine Fusion Proteins for Cancer Therapy; Gustavo Helguera and Manuel L. Penichet; 24 Synthesis and Biological Evaluation of a Paclitaxel Immunoconjugate; Ahmad Safavy and Kevin P. Raisch; 25 Cytotoxic Tumor Targeting with scFv Antibody-Modified Liposomes; Cornelia Marty and Reto A. Schwendener; 26 Intravenous Immunoglobulin Treatment for Fibrosis, Atherosclerosis, and Malignant Conditions; Ilan Krause and Yehuda Shoenfeld; 27 Study of T Cell Costimulatory Blockade In Vivo at a Single Cell Level; Minh Diem Vu and Xian Chang Li; 28 Stem Cell Transplantation: Graft-Mediated Anti-Leukemia Effects; William J. Hogan and H. Joachim Deeg; 29 Influence of Radiation Protocols on GvHD Incidence After Bone Marrow Transplantation in Experimental Models; Sebastian Schwarte and Matthias W. Hoffmann; 30 Induction of Chimerism and Tolerance Using Freshly Purified or Cultured Hematopoietic Stem Cells in Nonmyeloablated Mice; Nikos Emmanouilidis and Christian P. Larsen; 31 Induction of Mixed Versus Full Chimerism to Potentiate GvL Effects After Bone Marrow Transplantation; Markus Y. Mapara and Megan Sykes; 32 Application of Donor Lymphocytes Expressing a Suicide Gene for Early GvL Induction and Later Control of GvH Reactions After


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Product Details
  • ISBN-13: 9781592598625
  • Publisher: Humana Press Inc.
  • Publisher Imprint: Humana Press Inc.
  • Language: English
  • Sub Title: Methods and Protocols
  • ISBN-10: 1592598625
  • Publisher Date: 01 Jan 2005
  • Binding: Digital (delivered electronically)
  • Series Title: No. 109 Methods in Molecular Biology


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