About the Book
A cutting-edge review of the biochemical, physiological, pharmacological, genetic, and molecular interactions involved in the development and homeostasis of the skeleton. Topics range from chondrogenesis, chondrocytes, and cartilage to skeletal dysmorphology, and include the control of skeletal development, osteoblastic cell differentiation, and bone induction, growth, remodeling, and mineralization. The authors' understanding of bone physiology - and how it is modified throughout all the stages of life - offers novel approaches for improving the endurance of load-bearing implants, achieving life-long optimal bone strength, overcoming microgravity situations (space flight), and hastening the healing of fractures, osteotomies, and antrodeses.
Table of Contents:
I. Chondrogenesis, Chondrocytes, and Cartilage; Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis Rocky S. Tuan; Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling Lillian Shum, Yuji Hatakeyama, Julius Leyton, and Kazuaki Nonaka; Regulation of Chondrocyte Differentiation Andreia M. Ionescu, M. Hicham Drissi, and Regis J. O'Keefe; Continuous Expression of Cbfa1 in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfa1-Deficient Mice Shu Takeda, Jean-Pierre Bonnamy, Michael J. Owen, Patricia Ducy, and Gerard Karsenty; Molecular Biology and Biosynthesis of Collagens Johanna Myllyharju; Mechanotransduction Pathways in Cartilage Qian Chen; II. Control of Skeletal Development; Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development; Impact of the loxP/Cre System Marie Kmita, Denis Duboule, and Jozsef Zakany; Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling Renee Hackenmiller, Catherine Degnin, and Jan Christian; FGF4 and Skeletal Morphogenesis Valerie Ngo-Muller, Shaoguang Li, Scott A. Schaller, Manjong Han, Jennifer Farrington, Minoru Omi, Rosalie Anderson, and Ken Muneoka; Retinoid Signaling and Skeletal Development Andrea D. Weston and T. Michael Underhill; Retinoids and Indian Hedgehog Orchestrate Long Bone Development Maurizio Pacifici, Chiara Gentili, Eleanor Golden, and Eiki Koyama; III. Osteoblastic Cell Differentiation; Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation John C. Lee and Lee-Chuan C. Yeh; Bone Morphogenic Proteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis Cun-Yu Wang; Osteoclast Differentiation Sakamuri V. Reddy and G. David Roodman; IV. Bone Induction, Growth, and Remodeling; Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone Ugo Ripamonti, Nathaniel L. Ramoshebi, Janet Patton, Thato Matsaba, June Teare, and Louise Renton; Perichondrial and Periosteal Regulation of Endochondral Growth Dana L. Di Nino and Thomas F. Linsenmayer; Computer Simulations of Cancellous Bone Remodeling Jacqueline C. van der Linden, Harrie Weinans, and Jan A. N. Verhaar; Effects of Microgravity on Skeletal Remodeling and Bone Cells Pierre J. Marie; V. Bone Mineralization; Quantitative Analyses of the Development of Different Hard Tissues Siegfried Arnold, Hans J. Hohling, and Ulrich Plate; Fetal Mineral Homeostasis and Skeletal Mineralization Christopher S. Kovacs; Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D Johannes P. T. M. van Leeuwen, Marjolein van Driel, and Hulbert A. P. Pols; VI. Skeletal Dysmorphology; Role of Pax3 and PDGF-[alpha] Receptor in Skeletal Morphogenesis and Facial Clefting Simon J. Conway; Genetics of Achondroplasia and Hypochondroplasia Giedre Grigelioniene; Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat Michael G. Narotsky, Nathalie Wery, Bonnie T. Hamby, Deborah S. Best, Nathalie Pacico, Jacques J. Picard, Francoise Gofflot, and Robert J. Kavlock; Toxicant-Induced Lumbar and Cervical Ribs in Rodents John M. Rogers, R. Woodrow Setzer, and Neil Chernoff; Experimental Skeletal Dysmorphology: Risk Assessment Issues Rochelle W. Tyl, Melissa C. Marr, and Christina B. Myers; Index
