About the Book
World reknown basic scientists and clinical researchers update the wealth of new molecular knowledge that sees cancer as a 'disease process' involving key regulatory pathways. Emphasizing prevention, early diagnosis, prognosis, and treatment, these authoritative experts from around the world illuminate the variety of molecular markers to be found, interpret what is known about diseased regulatory pathways, and examine those future research directions likely to realize the promise of molecular therapy. From their presentations, readers will gain an understanding of the new processes now available to identify specific molecular targets for optimal therapeutic efficacy. Comprehensive and path-breaking, "Principles of Molecular Oncology, Second Edition" offers both basic and clinical oncologists not only a bold synthesis of the rapid and complex advances in molecular biology that are transforming our knowledge of cancer, but also a highly practical guide to today's strategies for its diagnosis and treatment.
Table of Contents:
Part I. Molecular Markers Selecting the Right Targets for Cancer Therapy Miguel H. Bronchud Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful Daniel F. Hayes Genetic Markers in Sporadic Tumors Antonella Aiello, Elena Tamborini, Milo Frattini, Federica Perrone, Maria Oggionni, Silvana Pilotti, and Marco A. Pierotti Genetic Markers in Breast Tumors with Hereditary Predisposition Tatyana A. Grushko and Olufunmilayo I. Olopade Cellular and Tissue Markers in Solid Tumors Barbro Linderholm, Thomas Lindahl, John Ohd, and Jonas Bergh Molecular and Pathologic Characterization of Human Tumors Chris Jones, Ming-Qing Du, and Sunil R. Lakhani Circulating Tumor Markers Alan Horwich and Gill Ross Proteomics-Based Approaches: New Opportunities in Cancer Research Rachel A. Craven, Peter J. Selby, and Rosamonde E. Banks Part II. Diseased Regulatory Pathways Growth Factor Signaling Pathways in Cancer Daniel Kalderon Estrogen Action and Breast Cancer Jennifer E. Fox, Hong Liu, and V. Craig Jordan Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics Miguel H. Bronchud, Leonardo Brizuela, Jeno Gyuris, and Muzammil M. Mansuri Angiogenesis Switch Pathways Jaume Piulats and Francesc Mitjans Invasion and Metastasis Maria Rosa Bani and Raffaella Giavazzi Molecular Pathways of Drug Resistance Linda E. Broker, Jose A. Rodriguez, and Giuseppe Giaccone Genomic Instability, DNA Repair Pathways, and Cancer Gabriel Capella and Miguel Angel Peinado Part III. Future Directions Immunotherapy for Human Cancer: Evidence and Obstacles Angelo A. Cardoso, W. Nicholas Haining, Marina Leite, and Sara Maia Treatment with Monoclonal Antibodies Gisela Schwab, Lorin Roskos, and C. Geoffrey Davis Emerging Molecular Therapies: Drugs Interfering with Signal Transduction Pathways Richard Baird and Paul Workman Treatment of Carcinogenesis M. Suzanne Stratton, Steven P. Stratton, Sara O. Dionne, Patricia Thompson, Ian N. Jongewaard, Iman Hakim, Tarrah Dilley, Linda Garland, James Ranger-Moore, David S. Alberts, and Frederick M. Ahmann Suicide Gene Therapy Ion Niculescu-Duvaz and Caroline J. Springer Glossary Index
Review :
this is an excellent book that brings together leading experts in the field who have done a superb job of succinctly describing the advances in the basic sciences over the last few years and in showing how these advances have translated into improvements in cancer care. This book will be useful to anyone who studies cancer biology or takes care of cancer patients. - Doody's Health Sciences Book Review Journal From the foreword: Principles of Molecular Oncology provides valuable information for the continuing education of all oncologists. - Derek Crowther, PhD, MB BChir, FRCP, FRCR, University of Manchester and Christie Cancer Center, Manchester, UK Reviews of the First Edition: All the aspects of this complex and rapidly moving field are covered in this excellent book. Clinical oncologists will find a series of balanced reviews of the current state-of-the-art of the diagnosis and treatment of cancer based on molecular technology, and since cancer touches almost every field of clinical practice, specialists in other disciplines will find a very lucid and readable account of what is happening in one of the genuine success stories of molecular medicine. From the foreword by Sir David Weatherall, FRS, Institute of Molecular Medicine, Oxford University, UK Principles of Molecular Oncology provides a bold new look at the evolution of our knowledge of cancer. Authors from many disciplines are bringing together the facets that provide a comprehensive view of the whole...The reader will enjoy the opportunity to pause and look at the whole field as it stands today. The book will be both informative and intellectually stimulating. From the foreword by E. Donnall Thomas, MD, Fred Hutchinson Cancer Research Center and Nobel Laureate in Medicine/Physiology, 1990 This book is a broad yet comprehensive synopsis of the emerging field of molecular oncology...A detailed framework of the molecular basis of cancer and the potential utility in both diagnosis and treatment is presented. One area covered particularly well is apoptosis, with an emphasis on the clinical relevance of modulating this pathway in human neoplasia. In summary, this text is a nice presentation of the varied pathways that are disrupted in a cancer cell and suggestions of potential clinically useful targets for therapeutic intervention...This is a welcome addition to a clinician's library, facilely read from cover to cover. - Doody's Health Sciences Book Review Journal Practicing physicians and advanced medical students as well as biochemists molecular biologists, and geneticists involved in the identification of molecular markers, therapeutic targets , and the underlying basis of cancer will all benefit from the addition of Principles of Molecular Oncology to their bookshelves. - The Lancet
