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The Art, Science, and Technology of Pharmaceutical Compounding

The Art, Science, and Technology of Pharmaceutical Compounding


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About the Book

The Art, Science, and Technology of Pharmaceutical Compounding presents in a logical and progressive format all the information that pharmacists and student pharmacists need to understand the purpose and processes of compounding. Author Loyd V. Allen Jr., the preeminent expert, covers basic guidelines, economic and technical factors that compounding pharmacists must consider, and all aspects of good manufacturing practices for compounded medications. In this fth edition, all chapters have been updated and several signicantly revised—particularly “Compounding with Hazardous Drugs”—and three new chapters have been added: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.” Information on the new law affecting compounding, the Drug Quality and Security Act, is incorporated throughout the book. Chapter 14 now includes information on compounding “ lms.”

Key Features:

  • The initial chapters describe the requisite facilities and equipment, record keeping, calculations, and quality control.
  • Three new chapters: “Pharmaceutical Compounding Errors,” “Foams,” and “Compounding with Special Ingredients.”
  • Fifteen chapters are devoted to the compounding of each dosage form in turn, from
  • powders and granules to injectables.
  • Additional chapters cover veterinary compounding, compounding for special populations,
  • compounding for speci c procedures, compounding for clinical studies, compounding
  • cosmetics, compounding with hazardous drugs, and compounding in the event of a natural
  • disaster or terrorist attack.
  • Nine appendices provide essential information on the compounding process and
  • examples of standard operating procedures.
  • The necessary ingredients and steps are listed for compounding more than 200 sample
  • formulations, including bases, vehicles, and ingredient-speci c preparations.
  • Updated throughout, including information on the new Drug Quality and Security Act.


Table of Contents:
  • Preface
  • Introduction
  • Abbreviations and Approximate Solubility
  • Descriptors
  • 1. Laws, Regulations, Standards and
  • Guidelines for Compounding
  • Practices
  • 2. Compounding Ingredient
  • Considerations
  • 3. Compounding with Hazardous Drugs
  • 4. Facilities, Equipment, and Supplies
  • 5. Records and Record Keeping
  • 6. Stability of Compounded
  • Preparations
  • 7. Pharmaceutical Compounding
  • Calculations
  • 8. Quality Control
  • 9. Flavors, Sweeteners, and Colors
  • 10. Preservation, Sterilization, and
  • Depyrogenation
  • 11. Powders and Granules
  • 12. Capsules
  • 13. Tablets
  • 14. Lozenges, Troches, and Films
  • 15. Suppositories and Inserts
  • 16. Sticks
  • 17. Solutions
  • 18. Suspensions
  • 19. Emulsions
  • 20. Foams
  • 21. Ointments, Creams, and Pastes
  • 22. Gels
  • 23. Ophthalmic, Otic, and Nasal
  • Preparations
  • 24. Inhalation Preparations
  • 25. Parenteral Preparations
  • 26. Biotechnology, Nanotechnology, and
  • Pharmacogenomics
  • 27. Special Populations and Preparations
  • 28. Compounding with Special
  • Ingredients
  • 29. Veterinary Pharmaceuticals
  • 30. Compounding for Clinical and
  • Investigational Studies
  • 31. Cosmetics for Special Populations
  • and for Use as Vehicles
  • 32. Compounding for Terrorist Attacks
  • and Natural Disasters
  • 33. Pharmaceutical Compounding Errors
  • Appendix I – Drugs and Dosage Forms
  • Not to be Compounded (The FDA
  • Negative List)
  • Appendix II – Standard Operating
  • Procedures
  • Appendix III – Speci c Gravity Values of
  • Selected Liquids
  • Appendix IV – Using Weight-Related
  • Conversion Factors
  • Appendix V – Sodium Chloride Equivalent
  • Values of Selected Agents
  • Appendix VI – Buffers and Buffer Solutions
  • Appendix VII – Compendial Requirements
  • for Bacterial Endotoxins in Sterile
  • Preparations
  • Appendix VIII – Viscosity-Increasing Agents
  • for Aqueous and Nonaqueous Systems
  • Appendix IX – Disinfecting Agents Used in
  • Compounding Pharmacies
  • Index


About the Author :
Loyd V. Allen, Jr. PhD, is Editorin- Chief, International Journal of Pharmaceutical Compounding and Remington: The Science and Practice of Pharmacy, and Professor Emeritus, College of Pharmacy, University of Oklahoma, Oklahoma City.


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Product Details
  • ISBN-13: 9781582122632
  • Publisher: American Pharmacists Association
  • Publisher Imprint: American Pharmacists Association
  • Edition: New edition
  • Language: English
  • Returnable: N
  • ISBN-10: 1582122636
  • Publisher Date: 30 Jul 2016
  • Binding: Hardback
  • Height: 254 mm
  • No of Pages: 650
  • Width: 178 mm


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