Tuberculosis and the Tubercle Bacillus

topics of particular interest include: comparative genome structure and transcriptome; biology of mycobacterial growth; biology of Mycobacterium tuberculosis in mammalian hosts; mechanisms of tuberculosis drug action; unique properties of the mycobacteria family.

Table of Contents:
Table of Contents Introduction I. Historical Perspectives 1. Global Burden of Tuberculosis: Past, Present, and Future, Liz Corbett and Mario Raviglione II. Clinical and Epidemiological Perspectives 2. Overview of Clinical Tuberculosis, Philip C. Hopewell and Robert M. Jasmer 3. Molecular Epidemiology of Mycobacterium tuberculosis, M. Donald Cave, Megan Murray, and Edward Nardell III. Diagnostics 4. Clinical Mycobacteriology (Tuberculosis) Laboratory: Services and Methods, Leonid Heifets and Edward Desmond 5. Immune-Based Methods, Suman Laal and Yasir A. W. Skeiky 6. Molecular Diagnosis of Mycobacterial Infections, Betty A. Forbes, Gaby Pfyffer, and Kathleen D. Eisenach IV. Current Therapies and Drug Resistance 7. Global Impact of Multidrug Resistance, Marcos A. Espinal and Max Salfinger 8. Mechanisms of Drug Resistance in Mycobacterium tuberculosis, Ying Zhang, Catherine Vilcheze, and William R. Jacobs, Jr. The Organism Mycobacterium tuberculosis V. Genomics 9. Introduction to Functional Genomics of the Mycobacterium tuberculosis Complex, Priscille Brodin, Caroline Demangel, and Stewart T. Cole 10. Comparative Genomics and Evolution of Mycobacterium bovis BCG, Roland Brosch and Marcel A. Behr 11. TB or Not TB: a Structural Genomics Mission? Celia W. Goulding, Debnath Pal, and David Eisenberg VI. Genetics 12. Gene Replacement Systems, Neil G. Stoker, P. Sander, and J. M. Reyrat 13. Repetitive DNA in the Mycobacterium tuberculosis Complex, Stephen V. Gordon and Philip Supply 14. Mycobacteriophages and Tuberculosis, Graham F. Hatfull 15. Control of Mycobacterial Transcription, Issar Smith, William R. Bishai, and Valakunja Nagaraja VII. Cell Structure 16. The Proteome of Mycobacterium tuberculosis, John T. Belisle, Miriam Braunstein, Ida Rosenkrands, and Peter Andersen 17. The Cell Envelope of Mycobacterium tuberculosis with Special Reference to the Capsule and Outer Permeability Barrier, Philip Draper and Mamadou Daffe 18. Structure, Biosynthesis, and Genetics of the Myolic Acid-Arabinogalactan-Peptidoglycan Complex, Sebabrata Mahapatra, Joyoti Basu, Patrick J. Brennan, and Dean C. Crick 19. A Waxy Tale, by Mycobacterium tuberculosis, Laurent Kremer and Gurdyal S. Besra VIII. Metabolism 20. General Metabolism and Biochemical Pathways of Tubercle Bacilli, Paul R. Wheeler and John S. Blanchard 21. Iron Metabolism in the Tubercle Bacillus and Other Mycobacteria, Luis E. N. Quadri and Colin Ratledge 22. Two-Component Systems, Protein Kinases, and Signal Transduction in Mycobacterium tuberculosis, Yossef Av-Gay and Vojo Deretic 23. Nucleic Acid Metabolism, Valerie Mizrahi, Michael Buckstein, and Harvey Rubin 24. Transport Processes, Jean Content, Martine Braibant, Nancy D. Connell, and Jose A. Ainsa Host-Pathogen Interactions IX. Phagocytic Uptake and Intracellular Survival 25. Receptor-Mediated Recognition of Mycobacterium tuberculosis by Host Cells, Matthew J. Fenton, Lee W. Riley, and Larry S. Schlesinger 26. Mycobacterium tuberculosis: the Indigestible Microbe, David G. Russell 27. Intracellular Models of Mycobacterium tuberculosis Infection, John Chan, Richard Silver, Beate Kampmann, and Robert S. Wallis 28. Dendritic Cells in Host Immunity to Mycobacterium tuberculosis, Marc Mendelson, Willem Hanekom, and Gilla Kaplan X. Host Immune Responses and Antigenic Variation 29. CD8 T Cells in Tuberculosis, Stefan H. E. Kaufmann and JoAnne L. Flynn 30. CD1 and Tuberculosis, Christopher C. Dascher and Michael B. Brenner 31. Th1 and Th2 Cytokines in the Human Immune Response to Tuberculosis, Peter F. Barnes and Ramakrishna Vankayalapati 32. Role of Antibody-Mediated Immunity in Host Defense against Mycobacterium tuberculosis, Aharona Glatman-Freedman and Arturo Casadevall 33. The PE and PPE Multigene Families of Mycobacteria, Michael J. Brennan, Nico C. Gey van Pittius, and Clara Espitia XI. Animal Models 34. Mycobacterium marinarum and Fish and Frog Models of Infection, Michele Trucksis, Christopher L. Pritchett, and Renate Reimschuessel 35. Experimental Infection Models of Tuberculosis in Domestic and Wild Animals, Bryce M. Buddle, John M. Pollock, and R. Glyn Hewinson 36. Animal Models of Tuberculosis, JoAnne L. Flynn, Andrea M. Cooper, and William Bishai 37. Tuberculosis Vaccine Preclinical Screening and Development, Ian M. Orme and Angelo A. Izzo