Image-Guided Hypofractionated Stereotactic Radiosurgery: A Practical Approach to Guide Treatment of Brain and Spine Tumors

The recent development of hypofractionated stereotactic radiation therapy (SRT), which calls for one to five fractions of high-dose radiation to be administered using special equipment, has resulted in the need for education on practice guidelines. Image-Guided Hypofractionated Stereotactic Radiosurgery: A Practical Approach to Guide Treatment of B

Table of Contents:
Invited Perspectives on Hypofractionated Stereotactic Radiosurgery. Tumor Vascular Conundrum: Hypoxia, Ceramide, and Biomechanical Targeting of Tumor Vasculature. Gamma Knife: From Single-Fraction SRS to IG-HSRT. CyberKnife Image-Guided Hypofractionated Stereotactic Radiotherapy. Linac-Based IG-HSRT Technology. Advanced MRI for Brain Metastases. From Frame to Frameless: Brain Radiosurgery. Principles of Image-Guided Hypofractionated Stereotactic Radiosurgery for Brain Tumors. Principles of Image-Guided Hypofractionated Radiotherapy of Spine Metastases. Spine Stereotactic Body Radiotherapy for the Treatment of De Novo Spine Metastasis. Image-Guided Hypofractionated Stereotactic Radiotherapy for Reirradiation of Spinal Metastases. IG-HSRT for Benign Tumors of the Spine. Postoperative Spine IG-HSRT Outcomes. Postoperative Cavity Image-Guided Stereotactic Radiotherapy Outcomes. Brain Metastases Image-Guided Hypofractionated Radiation Therapy: Rationale, Approach, Outcomes. Image-Guided Hypofractionated Stereotactic Whole-Brain Radiotherapy and Simultaneous Integrated Boost for Brain Metastases. Image-Guided Hypofractionated Radiation Therapy for High-Grade Glioma. Benign Brain Tumors. Radiation Necrosis. Vertebral Compression Fracture Post-Spine SBRT. Spinal Cord Dose Limits for Stereotactic Body Radiotherapy. Summary of Image-Guided Hypofractionated Stereotactic Radiotherapy: Serious Late Toxicities and Strategies to Mitigate Risk.

About the Author :
Arjun Sahgal, MD (chief editor), is a leader in the field of high-precision stereotactic radiation to the brain and spine. After training at the University of Toronto, Ontario, Canada, in radiation oncology, he completed a fellowship at the University of California, San Francisco, in brain and spine radiosurgery with Dr. David Larson. Since then he has been recognized as a national and international clinical expert and research leader in radiosurgery. His main focus is on developing spine stereotactic body radiotherapy as an effective therapy for patients with spinal tumors. He has published numerous book chapters on the subject and more than 200 peer-reviewed papers in high-impact journals, including Journal of Clinical Oncology and The Lancet Oncology. He has edited or written several books specific to research on brain and bone metastases and is an editorial board member for several journals. He was chairman of the International Stereotactic Radiosurgery Society meeting (June 2013) and was a board member for the Brain Tumour Foundation of Canada and the International Stereotactic Radiosurgery Society. He has been invited to speak at several international meetings, has been a visiting professor at various universities, and leads several research groups. His further research activities involve integrating MRI into radiotherapy delivery, combining novel pharmacologic therapies with radiosurgery, and MRI-guided focused ultrasound. Simon S. Lo, MD, is professor of radiation oncology at Case Western Reserve University, Cleveland, Ohio, and director of radiosurgery services and neurologic radiation oncology at University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, Ohio. Dr. Lo graduated from the Faculty of Medicine of The Chinese University of Hong Kong and did his residency in clinical oncology (Royal College of Radiologists, UK curriculum) at Queen Elizabeth Hospital, Hong Kong. He subs

Review :
"… a caregiver’s roadmap for a panoply of common clinical scenarios encountered in radiosurgical care of patients with cancer. … An awareness of how much this book can help in very practical terms is a good first step to helping your patients." —Jonathan P.S. Knisely, MD, Department of Radiation Medicine, Center for Advanced Medicine, Northwell Health, Lake Success, New York, USA "… a pragmatic approach to the emerging use of image-guided hypofractionated stereotactic radiosurgery for brain and spinal tumors. Each clinical chapter has a very useful checklist specific to brain and spinal indications, which facilitates implementation of the concepts." —John H. Suh, MD, Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic Foundation, Ohio, USA "… a much-needed overview of focal hypofractionated stereotactic radiosurgery for brain and spine tumors. The authors are experts, and as a result this book represents a most comprehensive, practical, and authoritative guide for practitioners." —David A. Larson, MD, Professor, Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, USA "From brain metastases to spinal metastases to high-grade gliomas to benign brain tumors, there are pearls of wisdom here to help practicing neurosurgical oncologists and radiation oncologists take the best care of their patients. A must read!" —James T. Rutka, MD, PhD, RS McLaughlin Professor and Chair, Department of Surgery, University of Toronto, Ontario, Canada "… a comprehensive discussion of radiosurgery biology, imaging, techniques, and management of value for both single-session and hypofractionated approaches." —Douglas Kondziolka, MD, Professor and Director, Center for Advanced Radiosurgery, NYU Langone Medical Center, New York City, New York, USA "… includes a wealth of treatment opportunities to further improve upon efficient, effective, and safer opportunities for our patients." —Helen A. Shih, MD, Chief, CNS and Eye Services, Department of Radiation Oncology, and Associate Medical Director, Francis H. Burr Proton Therapy Center, Massachusetts General Hospital, Boston, USA "Expert practitioners document the state of the art of this new discipline of neurosurgery and radiation oncology." —John R. Adler, Jr., MD, Dorothy and TK Chan Professor Emeritus, Stanford University, California, USA "… provides an invaluable guide through the technical tricks and traps, and beyond into safe practice." —Anthony L. Zietman, MD, Jenot W. and William U. Shipley Professor of Radiation Oncology, Harvard Medical School, and Associate Director, Radiation Oncology Residency Program, Massachusetts General Hospital, Boston, USA "This book is packed with expert perspectives on both single and hypofractionated radiosurgery for brain and spine, presenting state-of-the-art techniques in this emerging field." —Ian Paddick, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK "… covers the relevant indications for hypofractionated radiosurgery and helps readers understand the basic principles in this fast-evolving field in radiation medicine." —Alex Muacevic, MD, Professor, University of Munich, and Director, Cyberknife Center Munich, Germany "This book has a specific focus on HSRT for brain and spine. It comprehensively covers the radiobiology, physics, clinical management and treatment outcomes for metastases and primary CNS tumors. This book will be very useful in helping clinics to implement HSRT programs and to guide their clinical practices." - Ning Wen Ph.D. American Association of Physicists in Medicine "… a caregiver’s roadmap for a panoply of common clinical scenarios encountered in radiosurgical care of patients with cancer. … An awareness of how much this book can help in very practical terms is a good first step to helping your patients." —Jonathan P.S. Knisely, MD, Department of Radiation Medicine, Center for Advanced Medicine, Northwell Health, Lake Success, New York, USA "… a pragmatic approach to the emerging use of image-guided hypofractionated stereotactic radiosurgery for brain and spinal tumors. Each clinical chapter has a very useful checklist specific to brain and spinal indications, which facilitates implementation of the concepts." —John H. Suh, MD, Department of Radiation Oncology, Brain Tumor Institute, Cleveland Clinic Foundation, Ohio, USA "… a much-needed overview of focal hypofractionated stereotactic radiosurgery for brain and spine tumors. The authors are experts, and as a result this book represents a most comprehensive, practical, and authoritative guide for practitioners." —David A. Larson, MD, Professor, Departments of Radiation Oncology and Neurological Surgery, University of California, San Francisco, USA "From brain metastases to spinal metastases to high-grade gliomas to benign brain tumors, there are pearls of wisdom here to help practicing neurosurgical oncologists and radiation oncologists take the best care of their patients. A must read!" —James T. Rutka, MD, PhD, RS McLaughlin Professor and Chair, Department of Surgery, University of Toronto, Ontario, Canada "… a comprehensive discussion of radiosurgery biology, imaging, techniques, and management of value for both single-session and hypofractionated approaches." —Douglas Kondziolka, MD, Professor and Director, Center for Advanced Radiosurgery, NYU Langone Medical Center, New York City, New York, USA "… includes a wealth of treatment opportunities to further improve upon efficient, effective, and safer opportunities for our patients." —Helen A. Shih, MD, Chief, CNS and Eye Services, Department of Radiation Oncology, and Associate Medical Director, Francis H. Burr Proton Therapy Center, Massachusetts General Hospital, Boston, USA "Expert practitioners document the state of the art of this new discipline of neurosurgery and radiation oncology." —John R. Adler, Jr., MD, Dorothy and TK Chan Professor Emeritus, Stanford University, California, USA "… provides an invaluable guide through the technical tricks and traps, and beyond into safe practice." —Anthony L. Zietman, MD, Jenot W. and William U. Shipley Professor of Radiation Oncology, Harvard Medical School, and Associate Director, Radiation Oncology Residency Program, Massachusetts General Hospital, Boston, USA "This book is packed with expert perspectives on both single and hypofractionated radiosurgery for brain and spine, presenting state-of-the-art techniques in this emerging field." —Ian Paddick, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK "… covers the relevant indications for hypofractionated radiosurgery and helps readers understand the basic principles in this fast-evolving field in radiation medicine." —Alex Muacevic, MD, Professor, University of Munich, and Director, Cyberknife Center Munich, Germany