This book presents the basic principles and new and emergent clinical applications of BOLD fMRI. It describes the physical principles of BOLD fMRI imaging and reviews scanning methodologies, data analysis, challenges and limitations of BOLD fMRI, neurovascular uncoupling, and functional connectivity. The book also explores current and future clinical applications of BOLD fMRI in the fields of language, memory, fMRI WADA, visual pathway, brain mapping of eloquent cortex, pediatrics, auditory pathways, epilepsy, psychiatric disorders, neurodegenerative disorders, pharmacological applications, and cognitive neuroscience. It concludes with a discussion of BOLD fMRI paradigms that can be used for clinical and cognitive experiments. Derived from Faro, Mohamed, Law, and Ulmer’s Functional Neuroradiology: Principles and Applications, this book is a valuable resource for neurologists, cognitive neuroscientists, and neuroradiologists.
Table of Contents:
Part I: BOLD Functional MRI: Physical Principles.- Principles of BOLD Functional MRI.- fMRI Scanning Methods.- Experimental Design and Data Analysis for fMRI.- Challenges in fMRI and Its Limitations.- Neurovascular Uncoupling in Functional MR Imaging.- Functional Connectivity MR Imaging.- Clinical Challenges of Functional MRI.- Part II: Neuroanatomical Atlas.- Neuroanatomical Atlas of Key Presurgical and Cognitive Eloquent Cortex Regions.- Part III: BOLD Functional MRI: Clinical Applications.- fMRI of Language Systems: Methods and Applications.- Functional MRI Studies of Memory in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease.- fMRI Wada Test: Prospects for Presurgical Mapping of Language and Memory.- fMRI of Human Visual Pathways.- Brain Mapping for Neurosurgery and Cognitive Neuroscience.- Pediatric Applications of fMRI. - fMRI of the Central Auditory System.- fMRI of Epilepsy.- Applications of fMRI to Psychiatry.- Applications of fMRI to Neurodegenerative Disease.- Applications of MRI to Psychopharmacology.- Functional MRI: Cognitive Neuroscience Applications.- Part IV: fMRI Paradigms.- fMRI Paradigms.
Review :
“The book has a few chapters comprehensively
covering the methods and physical principles of the technique, written by
leading researchers in the field, but moves on to the practical challenges of
performing functional MRI in the clinic. … An appealing and highly useful
feature is the consistent use of tables referencing key papers relevant to that
chapter, highlighting their key findings. … a comprehensive text on the topic
of clinical fMRI this is an excellent read.” (Dr. Stuart Clare, RAD Magazine, November,
2015)
“This comprehensive introductory book on the principles and application of fMRI … is a welcome addition to the neuroscience literature. … The target audience includes physicians, psychiatrists, and neurologists, as well as trainees in these areas. … This is an excellent introductory book on BOLD fMRI. … Anyone who would like to attain basic fluency in this important research and clinical tool should read this outstanding book.” (Michael Joel Schrift, Doody's BookReviews, April, 2015)
